Neuralgia

3
Pipeline Programs
4
Companies
50
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
2
0
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Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

E
EisaiChina - Liaoning
2 programs
1
1
E2007Phase 2/31 trial
E2007Phase 21 trial
Active Trials
NCT00592774Completed146Est. Mar 2009
NCT00592904Completed262Est. Jul 2011
Sanofi
SanofiPARIS, France
1 program
1
Sodium ValproatePhase 2/31 trial
Active Trials
NCT00221637Terminated40Est. Jul 2005
M&
Merck & Co.RAHWAY, NJ
1 program
Development of a Bedside Pain Assessment Kit for Postherpetic NeuralgiaN/A1 trial
Active Trials
NCT01166295Unknown12Est. Nov 2010
Pfizer
PfizerNEW YORK, NY
1 program
PregabalinN/A5 trials
Active Trials
NCT02725112Completed25Est. Jun 2016
NCT01773993Completed534Est. Jul 2017
NCT01727791Completed10Est. Aug 2013
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin
PfizerPregabalin

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 9,554 patients across 50 trials

A Study Of Pregabalin (Lyrica) Drug Levels In Urine, Plasma And Breast Milk Of Healthy Lactating Women

Start: Dec 2012Est. completion: Aug 201310 patients
Phase 4Completed

Pilot Study Of Pregabalin And Prediction Of Treatment Response In Patients With Postherpetic Neuralgia

Start: Oct 2012Est. completion: Jun 20139 patients
Phase 4Terminated

Fibromyalgia of Less Than One Year Duration. Study of Pregabalin

Start: Sep 2011Est. completion: Mar 20140
Phase 4Withdrawn

Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia

Start: Jul 2010Est. completion: Jul 2012174 patients
Phase 4Completed

Effect on Anxiety in Partial Epilepsy Patients Treated With Pregabalin

Start: Apr 2010Est. completion: Jul 20144 patients
Phase 4Terminated

Lumbar Stenosis Outcomes Research (LUSTOR)

Start: Mar 2008Est. completion: Sep 201029 patients
Phase 4Completed

Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures

Start: Feb 2008Est. completion: Jul 2013482 patients
Phase 4Completed

A Prospective, Observational Study On The Effectiveness Of New Antiepileptic Drugs As First Bitherapy In The Daily Clinical Practice

Start: May 2007Est. completion: Jun 2009111 patients
Phase 4Completed

Pregabalin Treatment Of Peripheral Neuropathic Pain Associated With Diabetic Peripheral NeP (DPN), Postherpetic Neuralgia (PHN), HIV-related NeP (HIV), and Chemotherapy Induced NeP

Start: Jan 2007Est. completion: Jul 2008121 patients
Phase 4Completed

Lyrica (Pregabalin) Administered as an Add-on Therapy for Partial Seizures (LEADER).

Start: Dec 2005Est. completion: Dec 200798 patients
Phase 4Completed

A Study To Evaluate Pregabalin In Patients With Painful Diabetic Peripheral Neuropathy (DPN)

Start: Jan 2005Est. completion: May 2007450 patients
Phase 4Completed

Safety of Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy

Start: Jan 2005Est. completion: May 2006160 patients
Phase 4Completed

A Study of the Efficacy and Safety of Pregabalin for the Treatment of Diabetic Peripheral Neuropathy or Postherpetic Neuralgia

Start: Nov 2004Est. completion: Feb 2006217 patients
Phase 4Completed

Pregabalin in the Treatment of Pain Due to Diabetic Peripheral Neuropathy

Start: Sep 2004Est. completion: Oct 2005167 patients
Phase 4Completed

A 12-Month Study To Evaluate The Safety And Tolerability Of Pregabalin As Add-On Therapy In Pediatric Subjects 1 Month To 16 Years Of Age With Partial Onset Seizures And Pediatric And Adult Subjects 5 To 65 Years Of Age With Primary Generalized Tonic-Clonic Seizures

Start: Feb 2012Est. completion: Aug 2019605 patients
Phase 3Completed

A Study of the Efficacy and Safety of Pregabalin as Add-On Therapy for Partial Onset Seizures in Children Ages 4-16 Years

Start: Sep 2011Est. completion: Aug 2016295 patients
Phase 3Completed

Pregabalin Trial In HIV Neuropathic Pain

Start: Jul 2010Est. completion: May 2012217 patients
Phase 3Terminated

A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin In Patients With Fibromyalgia

Start: Jul 2009Est. completion: Feb 2011106 patients
Phase 3Completed

Extension Study Of Long-Term Safety And Efficacy Of Pregabalin As Monotherapy (Lyrica) In Patients With Partial Seizures

Start: Apr 2008Est. completion: Dec 201175 patients
Phase 3Completed

A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Pain Associated With Diabetic Peripheral Neuropathy

Start: Feb 2008Est. completion: Jan 2010123 patients
Phase 3Completed

Pregabalin Versus Levetiracetam In Partial Seizures

Start: Oct 2007Est. completion: May 2012509 patients
Phase 3Completed

Efficacy And Safety Study Of Pregabalin (Lyrica) As Monotherapy In Patients With Partial Seizures

Start: Sep 2007Est. completion: Jun 2011161 patients
Phase 3Terminated

A Long-Term Study To Evaluate Safety And Efficacy Of Pregabalin For Postherpetic Neuralgia

Start: Jan 2007Est. completion: Aug 2008126 patients
Phase 3Completed

A Safety Study Of Pregabalin In Fibromyalgia

Start: Feb 2006Est. completion: Oct 2006500 patients
Phase 3Completed

A Study to Assess the Efficacy, Safety and Tolerability of Pregabalin in Patients With Symptoms of Neuropathic Pain

Start: Feb 2006Est. completion: Sep 2007309 patients
Phase 3Completed

Pregabalin Epilepsy Add-On Trial

Start: Oct 2005Est. completion: Aug 2006178 patients
Phase 3Completed

Trial of Efficacy and Safety of Pregabalin in Subjects With Neuropathic Pain Associated With Lumbo-Sacral Radiculopathy

Start: Apr 2005Est. completion: Jun 2007276 patients
Phase 3Completed

Pregabalin In Partial Seizures Extension Study

Start: Apr 2005Est. completion: Sep 2007227 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Pregabalin (Lyrica) for the Treatment of Nerve Pain

Start: Nov 2004Est. completion: Mar 2005112 patients
Phase 3Completed

To Evaluate Long-Term Safety and Efficacy of Pregabalin in the Treatment of Neuropathic Pain After Spinal Cord Injury.

Start: Aug 2002Est. completion: Jan 2006132 patients
Phase 3Completed

Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Start: Mar 2002Est. completion: Nov 2005337 patients
Phase 3Completed

To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Postherpetic Neuralgia.

Start: Feb 2002Est. completion: Jul 2005276 patients
Phase 3Completed

Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Chronic Neuropathic Pain.

Start: Oct 2001Est. completion: Aug 2005325 patients
Phase 3Completed

Determine Long-Term Safety and Tolerability of Pregabalin in Patients With Anxiety Disorders.

Start: Jan 2001Est. completion: Mar 2006511 patients
Phase 3Completed

To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.

Start: Nov 1999Est. completion: Jul 2005750 patients
Phase 3Completed

Safety and Efficacy of Pregabalin in Patients With Diabetic Peripheral Neuropathy.

Start: Sep 1999Est. completion: Jul 2005240 patients
Phase 3Completed

To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures

Start: Jul 1998Est. completion: Oct 2005455 patients
Phase 3Completed

Evaluating E2007 (Perampanel) in Patients With Painful Diabetic Neuropathy (PDN) or Post-Herpetic Neuralgia (PHN)

Start: Jan 2008Est. completion: Jul 2011262 patients
Phase 2/3Completed
NCT00221637SanofiSodium Valproate

Efficacy of Valproate in Peripheral Neuropathic Pain

Start: Mar 2002Est. completion: Jul 200540 patients
Phase 2/3Terminated

Dose-Tolerability Titration Study to Evaluate The Efficacy And Safety Of Perampanel (E2007) In Patients With Post-Herpetic Neuralgia (PHN)

Start: Jan 2008Est. completion: Mar 2009146 patients
Phase 2Completed

Bioavailability Study of Pregabalin Extended Release Formulation With Various Release Rates in Healthy Volunteers

Start: Feb 2016Est. completion: Jun 201625 patients
Phase 1Completed

A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted

Start: Mar 2012Est. completion: Apr 201216 patients
Phase 1Completed

An Investigation of the Effects of Erythromycin on the Pharmacokinetics of the Pregabalin Controlled Release Tablet

Start: Jun 2011Est. completion: Jul 201118 patients
Phase 1Completed

Investigation Of Absorption And Pharmacokinetics Of A Single Dose Of Controlled Release Pregabalin Tablet Administered Fasted In The Evening or Immediately Following A 600-750 Calorie Evening Meal As Compared To Single Dose Of Immediate Release Pregabalin Capsule In Healthy Volunteers

Start: Apr 2011Est. completion: Jun 201124 patients
Phase 1Completed

An Investigation Of The Absorption And Pharmacokinetics Of A Single Dose Of A Controlled Release (CR) Pregabalin Tablet Following Various Sized Lunches As Compared To A Single Dose Of The Immediate Release (IR) Pregabalin Capsule In Healthy Volunteers

Start: Mar 2011Est. completion: Apr 201128 patients
Phase 1Completed

An Investigation Of The Absorption And Pharmacokinetics Of A Single Dose Of A Controlled Release (CR) Pregabalin Tablet Following A Low, Medium, And High-Fat Evening Meal As Compared To A Single Dose Of The Immediate Release (IR) Pregabalin Capsule In Healthy Volunteers

Start: Mar 2011Est. completion: Apr 201128 patients
Phase 1Completed

Investigation Of Absorption And Pharmacokinetics Of A Single Dose Of Controlled Release Pregabalin Tablet Administered Fasted At Bedtime Or Immediately Following A 400-500 or 600-750 Calorie Evening Meal As Compared To Single Dose Of Immediate Release Pregabalin Capsule In Healthy Volunteers

Start: Feb 2011Est. completion: May 201124 patients
Phase 1Completed

An Investigation Of The Absorption And Pharmacokinetics Of Multiple Doses Of A Controlled Release Pregabalin Tablet As Compared To Multiple Doses Of The Immediate Release Pregabalin Capsule In Healthy Volunteers

Start: Feb 2011Est. completion: Mar 201118 patients
Phase 1Completed

An Investigation Of The Absorption And Pharmacokinetics Of Multiple Doses Of Two Controlled Release Pregabalin Tablets As Compared To Multiple Doses Of The Immediate Release Pregabalin Capsule In Healthy Volunteers

Start: Nov 2010Est. completion: Jan 201124 patients
Phase 1Completed

An Investigation Of The Absorption And Pharmacokinetics Of Multiple Doses Of Two Controlled Release Pregabalin Tablets As Compared To Multiple Doses Of The Immediate Release Pregabalin Capsule

Start: Oct 2010Est. completion: Nov 201024 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 companies competing in this space