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Neuralgia

7
Pipeline Programs
9
Companies
12
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
3
3
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Viatris
LYRICA CRApproved
pregabalin
Viatris
oral2017
402K Part D

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
6 programs
2
1
pregabalinPhase 4
PregabalinPhase 3
PregabalinPhase 31 trial
2-weeks placebo then gabapentinN/A
LyricaN/A
+1 more programs
Active Trials
NCT00150436Completed276Est. Jul 2005
Viatris
ViatrisCANONSBURG, PA
5 programs
1
1
pregabalinPhase 41 trial
PregabalinPhase 31 trial
2-weeks placebo then gabapentinN/A1 trial
LyricaN/A1 trial
PregabalinN/A1 trial
Active Trials
NCT00674687Completed23Est. Jun 2006
NCT00922987Completed286Est. Jun 2010
NCT01256593Completed3,827Est. Jul 2017
+2 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
AGN201781Phase 21 trial
Active Trials
NCT00533351Terminated9Est. Jun 2008
Eisai
EisaiChina - Liaoning
2 programs
E2007PHASE_21 trial
E2007PHASE_2_31 trial
Active Trials
NCT00592774Completed146Est. Mar 2009
NCT00592904Completed262Est. Jul 2011
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
Development of a Bedside Pain Assessment Kit for Postherpetic NeuralgiaN/A1 trial
Active Trials
NCT01166295Unknown12Est. Nov 2010
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Development of a Bedside Pain Assessment Kit for Postherpetic NeuralgiaN/A
MSD
MSDIreland - Ballydine
1 program
Development of a Bedside Pain Assessment Kit for Postherpetic NeuralgiaN/A
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
ExosomesN/A1 trial
Active Trials
NCT04202783Suspended100Est. Dec 2024
Sanofi
SanofiPARIS, France
1 program
Sodium ValproatePHASE_2_31 trial
Active Trials
NCT00221637Terminated40Est. Jul 2005

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Viatrispregabalin
ViatrisPregabalin
PfizerPregabalin
EisaiE2007
SanofiSodium Valproate
AbbVieAGN201781
EisaiE2007
Angeles TherapeuticsExosomes
ViatrisPregabalin
Sharp TherapeuticsDevelopment of a Bedside Pain Assessment Kit for Postherpetic Neuralgia
ViatrisLyrica
Viatris2-weeks placebo then gabapentin

Clinical Trials (12)

Total enrollment: 5,348 patients across 12 trials

P4 (Pregabalin for Peripheral Posttraumatic Pain)

Start: Jan 2006Est. completion: May 2008255 patients
Phase 4Completed

A Study to Evaluate the Efficacy and Safety of Pregabalin (Lyrica) for the Treatment of Nerve Pain

Start: Nov 2004Est. completion: Mar 2005112 patients
Phase 3Completed

To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Postherpetic Neuralgia.

Start: Feb 2002Est. completion: Jul 2005276 patients
Phase 3Completed

Evaluating E2007 (Perampanel) in Patients With Painful Diabetic Neuropathy (PDN) or Post-Herpetic Neuralgia (PHN)

Start: Jan 2008Est. completion: Jul 2011262 patients
Phase 2/3Completed
NCT00221637SanofiSodium Valproate

Efficacy of Valproate in Peripheral Neuropathic Pain

Start: Mar 2002Est. completion: Jul 200540 patients
Phase 2/3Terminated

Safety and Efficacy of AGN201781 in Neuropathic Pain

Start: Mar 2008Est. completion: Jun 20089 patients
Phase 2Terminated

Dose-Tolerability Titration Study to Evaluate The Efficacy And Safety Of Perampanel (E2007) In Patients With Post-Herpetic Neuralgia (PHN)

Start: Jan 2008Est. completion: Mar 2009146 patients
Phase 2Completed

The Use of Exosomes In Craniofacial Neuralgia

Start: Dec 2023Est. completion: Dec 2024100 patients
N/ASuspended

Safety And Efficacy Of Lyrica (Regulatory Post Marketing Commitment Plan)

Start: Feb 2011Est. completion: Jul 20173,827 patients
N/ACompleted
NCT01166295Sharp TherapeuticsDevelopment of a Bedside Pain Assessment Kit for Postherpetic Neuralgia

Development of a Bedside Pain Assessment Kit for Postherpetic Neuralgia

Start: Jul 2010Est. completion: Nov 201012 patients
N/AUnknown

Clinical Study With Lyrica In Patients Suffering From Epilepsy

Start: Sep 2009Est. completion: Jun 2010286 patients
N/ACompleted
NCT00674687Viatris2-weeks placebo then gabapentin

A Study Of The Efficacy Of Gabapentin In Neuropathic Pain Patients As Measured By Quantitative Sensory Testing

Start: Jul 2004Est. completion: Jun 200623 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.