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Long QT Syndrome

9
Pipeline Programs
12
Companies
15
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
0
2
0
0
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Purdue Pharma
Purdue PharmaCT - Stamford
3 programs
3
ProgesteronePhase 41 trial
ProgesteronePhase 41 trial
TestosteronePhase 41 trial
Active Trials
NCT03834883Completed27Est. May 2024
NCT04675788Completed73Est. Apr 2025
NCT02513940Completed14Est. Oct 2017
QT Medical
QT MedicalCA - Diamond Bar
1 program
1
QTScreen ECG RecorderPhase 2
Innovation Pharmaceuticals
1 program
1
QTScreen ECG RecorderPhase 21 trial
Active Trials
NCT02412709Unknown4,000Est. Mar 2017
Kite Pharma
Kite PharmaCA - El Segundo
4 programs
4
EleclazinePhase 11 trial
EleclazinePhase 11 trial
GS-6615Phase 11 trial
GS-6615Phase 11 trial
Active Trials
NCT02412098Completed49Est. Apr 2016
NCT02441829Completed55Est. Dec 2015
NCT02365532Completed60Est. May 2015
+1 more trials
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
3 programs
EleclazinePHASE_1
GS-6615PHASE_1
GS-6615PHASE_1
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
Dofetilide and/or sotalolN/A1 trial
Prospective Identification of Long QT Syndrome in Fetal LifeN/A
Active Trials
NCT02439658Unknown1,000Est. Apr 2023
Thryv Therapeutics
Thryv TherapeuticsQC - Montreal
2 programs
LQT-1213PHASE_11 trial
LQT-1213PHASE_1_21 trial
Active Trials
NCT05759962Completed50Est. Mar 2023
NCT05906732Terminated42Est. May 2024
Pediatrix Therapeutics
Pediatrix TherapeuticsChina - Shanghai
1 program
Multicenter Evaluation of Children and Young Adults With Genotype Positive Long QT SyndromeN/A1 trial
Active Trials
NCT01705925Completed92Est. Dec 2018
Utah Medical
Utah MedicalIreland - Dublin
1 program
Prospective Identification of Long QT Syndrome in Fetal LifeN/A1 trial
Active Trials
NCT02876380Completed25Est. Jul 2019
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
Simplified Cascade ScreeningN/A
Genome & Company
Genome & CompanyKorea - Suwon
1 program
Simplified Cascade ScreeningN/A1 trial
Active Trials
NCT03783975Terminated131Est. Dec 2022
Boston Scientific
Boston ScientificCA - Valencia
1 program
subcutaneous ICDN/A1 trial
Active Trials
NCT00399412Completed86Est. Dec 2007

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Purdue PharmaProgesterone
Purdue PharmaProgesterone
Purdue PharmaTestosterone
Innovation PharmaceuticalsQTScreen ECG Recorder
Thryv TherapeuticsLQT-1213
Thryv TherapeuticsLQT-1213
Kite PharmaEleclazine
Kite PharmaEleclazine
Kite PharmaGS-6615
Kite PharmaGS-6615
Genome & CompanySimplified Cascade Screening
Utah MedicalProspective Identification of Long QT Syndrome in Fetal Life
Colorado TherapeuticsDofetilide and/or sotalol
Pediatrix TherapeuticsMulticenter Evaluation of Children and Young Adults With Genotype Positive Long QT Syndrome
Boston Scientificsubcutaneous ICD

Clinical Trials (15)

Total enrollment: 5,728 patients across 15 trials

Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening

Start: Sep 2021Est. completion: Apr 202573 patients
Phase 4Completed

Reducing the Risk of Drug-Induced QT Interval Lengthening in Women

Start: Mar 2019Est. completion: May 202427 patients
Phase 4Completed

Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes

Start: May 2016Est. completion: Oct 201714 patients
Phase 4Completed

Long QT Syndrome Screening in Newborns

Start: Jun 2015Est. completion: Mar 20174,000 patients
Phase 2Unknown

Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2).

Start: Mar 2023Est. completion: May 202442 patients
Phase 1/2Terminated

Phase 1 Study of LQT-1213 in Healthy Adults

Start: Sep 2022Est. completion: Mar 202350 patients
Phase 1Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function

Start: May 2015Est. completion: Dec 201555 patients
Phase 1Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Hepatic Function

Start: Mar 2015Est. completion: Apr 201649 patients
Phase 1Completed

Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults

Start: Feb 2015Est. completion: May 201560 patients
Phase 1Completed

Study of the Effect of GS-6615 in Subjects With LQT-3

Start: May 2013Est. completion: Nov 201424 patients
Phase 1Completed
NCT03783975Genome & CompanySimplified Cascade Screening

KCNQ1 Cascade Screening

Start: Mar 2019Est. completion: Dec 2022131 patients
N/ATerminated
NCT02876380Utah MedicalProspective Identification of Long QT Syndrome in Fetal Life

Prospective Identification of Long QT Syndrome in Fetal Life

Start: Nov 2014Est. completion: Jul 201925 patients
N/ACompleted
NCT02439658Colorado TherapeuticsDofetilide and/or sotalol

Genetics of QT Prolongation With Antiarrhythmics

Start: Jan 2014Est. completion: Apr 20231,000 patients
N/AUnknown
NCT01705925Pediatrix TherapeuticsMulticenter Evaluation of Children and Young Adults With Genotype Positive Long QT Syndrome

Multicenter Evaluation of Children and Young Adults With Genotype Positive Long QT Syndrome

Start: Mar 2012Est. completion: Dec 201892 patients
N/ACompleted

ECG Signal Collection From Long QT Syndrome, Wide QRS Complexes, Heart Failure, and Cardiac Resynchronization Patients

Start: Nov 2006Est. completion: Dec 200786 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.