Long QT Syndrome

5
Pipeline Programs
2
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
1
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Thryv Therapeutics
Thryv TherapeuticsQC - Montreal
2 programs
1
1
LQT-1213Phase 1/21 trial
LQT-1213Phase 11 trial
Active Trials
NCT05759962CompletedEst. Mar 2023
NCT05906732TerminatedEst. May 2024
GS
Gilead SciencesFOSTER CITY, CA
3 programs
3
EleclazinePhase 12 trials
GS-6615Phase 14 trials
GS-6615Phase 1
Active Trials
NCT02441829Completed55Est. Dec 2015
NCT02412098Completed49Est. Apr 2016
NCT02377336Withdrawn0Est. Aug 2016
+3 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Gilead SciencesGS-6615
Gilead SciencesGS-6615
Thryv TherapeuticsLQT-1213
Thryv TherapeuticsLQT-1213
Gilead SciencesEleclazine
Gilead SciencesEleclazine
Gilead SciencesGS-6615
Gilead SciencesGS-6615

Clinical Trials (8)

Total enrollment: 360 patients across 8 trials

Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy

Start: Feb 2015Est. completion: Feb 2017172 patients
Phase 2/3Terminated

GS-6615 in Adults With Chronic Stable Angina and Coronary Artery Disease

Start: May 2015Est. completion: Aug 20160
Phase 2Withdrawn

Study of LQT-1213 on QTc-induced Prolongation in Healthy Adult Subjects (Part1) and on Congenital Long QT in Patients Diagnosed With Type 2 or 3 Long QT Syndrome (Part 2).

Start: Mar 2023Est. completion: May 2024
Phase 1/2Terminated

Phase 1 Study of LQT-1213 in Healthy Adults

Start: Sep 2022Est. completion: Mar 2023
Phase 1Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function

Start: May 2015Est. completion: Dec 201555 patients
Phase 1Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Hepatic Function

Start: Mar 2015Est. completion: Apr 201649 patients
Phase 1Completed

Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults

Start: Feb 2015Est. completion: May 201560 patients
Phase 1Completed

Study of the Effect of GS-6615 in Subjects With LQT-3

Start: May 2013Est. completion: Nov 201424 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 companies competing in this space