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Ischemia

4
Pipeline Programs
10
Companies
8
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Astellas
LEXISCANApproved
regadenoson
Astellas
Adenosine Receptor Agonist [EPC]intravenous2008

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
1 program
1
RegadenosonPhase 41 trial
Active Trials
NCT02130453Completed161Est. Jun 2024
Genentech
GenentechCA - Oceanside
1 program
1
beta-epoietinPhase 31 trial
Active Trials
NCT01450878Terminated6Est. Mar 2013
Imbria Pharmaceuticals
1 program
1
IMB-1018972Phase 21 trial
Active Trials
NCT04826172Completed58Est. Sep 2023
Medtronic
MedtronicNJ - Phillipsburg
1 program
Percutaneous coronary interventionN/A1 trial
Active Trials
NCT00669552Completed11Est. Jul 2012
Abbott
AbbottABBOTT PARK, IL
1 program
St. Jude Medical Pressure WireN/A1 trial
Active Trials
NCT02648230Completed74Est. Dec 2016
Kite Pharma
Kite PharmaCA - El Segundo
1 program
ambrisentanN/A1 trial
Active Trials
NCT01072669Completed20Est. Dec 2010
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
1 program
ambrisentanN/A
Lantheus Medical Imaging
1 program
BMS747158PHASE_21 trial
Active Trials
NCT00849108Completed176Est. Jun 2010
Bristol Myers Squibb
1 program
ClopidogrelPHASE_21 trial
Active Trials
NCT00360386Completed110Est. Feb 2005
Roche
RocheSTAVANGER NORWAY, Norway
1 program
beta-epoietinPHASE_3

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AstellasRegadenoson
Genentechbeta-epoietin
Imbria PharmaceuticalsIMB-1018972
Lantheus Medical ImagingBMS747158
Bristol Myers SquibbClopidogrel
AbbottSt. Jude Medical Pressure Wire
Kite Pharmaambrisentan
MedtronicPercutaneous coronary intervention

Clinical Trials (8)

Total enrollment: 616 patients across 8 trials

Accuracy of an Echo-Stress Protocol Using Regadenoson With Speckle Tracking

Start: Sep 2014Est. completion: Jun 2024161 patients
Phase 4Completed

Renal Graft Function After Treatment With Erythropoietin (EPO)

Start: Dec 2011Est. completion: Mar 20136 patients
Phase 3Terminated

Exploratory Study on the Safety, Tolerability, and Pharmacodynamics of IMB-1018972 in Subjects With Angina Due to Obstructive Coronary Artery Disease (IMPROVE-Ischemia)

Start: Apr 2021Est. completion: Sep 202358 patients
Phase 2Completed

Development of 1-Day Rest/Stress Cardiac PET Perfusion Imaging Protocol of BMS747158

Start: Jan 2009Est. completion: Jun 2010176 patients
Phase 2Completed

ALBION "Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis"

Start: Mar 2004Est. completion: Feb 2005110 patients
Phase 2Completed
NCT02648230AbbottSt. Jude Medical Pressure Wire

PrEssure wiRe Compared to Microcatheter-based Sensing Technology For the Evaluation of FFR Measurements

Start: Dec 2015Est. completion: Dec 201674 patients
N/ACompleted

Efficacy of Ambrisentan in Limited Scleroderma Patients in Improving Blood Flow to Hands or Feet

Start: Feb 2010Est. completion: Dec 201020 patients
N/ACompleted
NCT00669552MedtronicPercutaneous coronary intervention

Intracardiac T-wave Alternans and Ischemia

Start: Aug 2008Est. completion: Jul 201211 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.