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Invasive Fungal Infections

7
Pipeline Programs
12
Companies
10
Clinical Trials
1 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
1
0
1
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 11 programs with unclassified modality

On Market (2)

Approved therapies currently available

Pfizer
VFENDApproved
voriconazole
Pfizer
Azole Antifungal [EPC]intravenous2002
10K Part D
Pfizer
VORICONAZOLEApproved
voriconazole
Pfizer
Azole Antifungal [EPC]oral2016

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
voriconazolePhase 4Small Molecule1 trial
Active Trials
NCT00288197Completed77Est. Jun 2007
Astellas
AstellasChina - Shenyang
3 programs
1
MicafunginPhase 31 trial
MicafunginN/A1 trial
MicafunginN/A1 trial
Active Trials
NCT03174457Completed120Est. May 2018
NCT02678598Completed2,555Est. Aug 2015
NCT00048750Terminated104Est. Jun 2003
F2G
F2GUK - Manchester
2 programs
1
1
OlorofimPhase 2
OlorofimPhase 11 trial
Active Trials
NCT04039880Completed12Est. Sep 2019
Biosergen
BiosergenSweden - Solna
1 program
1
BSG005 or placeboPhase 11 trial
Active Trials
NCT04921254Unknown72Est. May 2023
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
2 programs
PET-CTN/A
PET-CTN/A
Eagle Pharmaceuticals
Eagle PharmaceuticalsNJ - Woodcliff Lake
1 program
Amphotericin B Liposome for InjectionN/A1 trial
Active Trials
NCT06977490Completed42Est. Oct 2025
Kite Pharma
Kite PharmaCA - El Segundo
1 program
PET-CTN/A1 trial
Active Trials
NCT05688592Recruiting224Est. Dec 2024
IQVIA
IQVIADURHAM, NC
1 program
OlorofimPHASE_22 trials
Active Trials
NCT07712484Not Yet Recruiting50Est. Jul 2028
NCT03583164Completed203Est. Feb 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Pfizervoriconazole
AstellasMicafungin
IQVIAOlorofim
IQVIAOlorofim
BiosergenBSG005 or placebo
F2GOlorofim
Eagle PharmaceuticalsAmphotericin B Liposome for Injection
Kite PharmaPET-CT
AstellasMicafungin
AstellasMicafungin

Clinical Trials (10)

Total enrollment: 3,459 patients across 10 trials

NCT00288197Pfizervoriconazole

A Study To Assess The Efficacy And Safety Of Voriconazole In Chinese Patients With Serious Deep Tissue Fungal Infections

Start: Jan 2006Est. completion: Jun 200777 patients
Phase 4Completed

Comparative Study of Micafungin (FK463) Versus Placebo as Prophylactic Antifungal Therapy in the ICU

Start: Jan 2003Est. completion: Jun 2003104 patients
Phase 3Terminated

A Phase II Randomized Study to Evaluate Measures for Endpoint Derivation in Patients With Progressive or Refractory Disseminated Coccidioidomycosis (DCM ) Treated With Olorofim Plus Baseline SOC or Placebo Plus Baseline SOC

Start: Dec 2026Est. completion: Jul 202850 patients
Phase 2Not Yet Recruiting

Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options

Start: Jun 2018Est. completion: Feb 2023203 patients
Phase 2Completed
NCT04921254BiosergenBSG005 or placebo

A Study to Assess the Safety, Tolerability and Pharmacokinetics of BSG005.

Start: Aug 2021Est. completion: May 202372 patients
Phase 1Unknown

Absorption, Metabolism and Excretion of 14C-olorofim in Man

Start: Jul 2019Est. completion: Sep 201912 patients
Phase 1Completed
NCT06977490Eagle PharmaceuticalsAmphotericin B Liposome for Injection

Human Bioequivalence Study of Amphotericin B Liposome for Injection

Start: May 2025Est. completion: Oct 202542 patients
N/ACompleted

Usefulness of PET-CT for Invasive Fungal Infection

Start: Apr 2023Est. completion: Dec 2024224 patients
N/ARecruiting

Non-interventional Study for Prevention and Treatment of Fungal Infections in Paediatric Patients in Asia/Oceania - ERADICATE Study

Start: Jun 2017Est. completion: May 2018120 patients
N/ACompleted

A Retrospective Study Evaluating the Efficacy and Safety of Micafungin Sodium in the Treatment of Invasive Fungal Infections

Start: Mar 2015Est. completion: Aug 20152,555 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 3,459 patients
12 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.