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Insulin Resistance

12
Pipeline Programs
25
Companies
21
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
0
2
0
2
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
583%
Peptide
117%
+ 20 programs with unclassified modality

Competitive Landscape

19 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
3 programs
1
1
1
NateglinidePhase 41 trial
VildagliptinPhase 3Small Molecule1 trial
BVS857Phase 11 trial
Active Trials
NCT01435330Completed43Est. Mar 2012
NCT01122641Completed15Est. Aug 2014
NCT00259168Completed70Est. Mar 2006
Bayer
BayerLEVERKUSEN, Germany
1 program
1
NateglinidePhase 4
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
AvandiaPhase 3
Genfit
GenfitFrance - Loos
1 program
1
GFT505 80mgPhase 21 trial
Active Trials
NCT01271777Completed22Est. Nov 2011
OrsoBio
OrsoBioCA - Palo Alto
1 program
1
TLC-3595 Dose 1Phase 21 trial
Active Trials
NCT05665751Active Not Recruiting76Est. Dec 2024
Innovation Pharmaceuticals
3 programs
1
KetoconazolePhase 1Small Molecule1 trial
Hypertonic SalineN/A1 trial
No applyN/A1 trial
Active Trials
NCT02761434Completed60Est. May 2017
NCT03244449Completed81Est. Dec 2016
NCT02256865Completed40Est. Oct 2023
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
1
PolyphenolsPhase 11 trial
Oral Glucose Tolerance TestN/A1 trial
Active Trials
NCT04089332Completed23Est. Jul 2022
NCT00668928Completed20Est. Dec 2007
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AtropinePhase 11 trial
Active Trials
NCT00689208Completed12Est. Nov 2008
Incyte
IncyteDE - Wilmington
1 program
1
INCB13739Phase 11 trial
Active Trials
NCT00398619CompletedEst. Mar 2007
Kite Pharma
Kite PharmaCA - El Segundo
1 program
1
Tenofovir disaproxil fumarate/emtricitabine/elvitegravir/cobicistatPhase 1Small Molecule1 trial
Active Trials
NCT02203461Completed30Est. Oct 2014
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
2 programs
Growth hormoneN/A1 trial
LiraglutidePHASE_4Peptide1 trial
Active Trials
NCT00568568Completed8Est. Feb 2010
NCT02403284Completed97Est. Nov 2023
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
2 programs
Tenofovir disaproxil fumarate/emtricitabine/elvitegravir/cobicistatPHASE_1Small Molecule
Tenofovir disaproxil fumarate/emtricitabine/elvitegravir/cobicistatPHASE_1Small Molecule
Physical Sciences
Physical SciencesMA - Andover
1 program
Circuit trainingN/A1 trial
Active Trials
NCT04528693Completed49Est. Jun 2025
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
EstradiolN/A1 trial
Active Trials
NCT01605071Completed53Est. Jan 2017
Abbott
AbbottABBOTT PARK, IL
1 program
RosiglitazoneN/A1 trial
Active Trials
NCT00186537Completed47Est. Sep 2008
Enterprise Therapeutics
1 program
Water ControlN/A1 trial
Active Trials
NCT03102463Completed6Est. Jun 2017
Genentech
GenentechCA - Oceanside
1 program
BFKB8488APHASE_11 trial
Active Trials
NCT02593331Completed79Est. Mar 2017
GSK
GSKLONDON, United Kingdom
1 program
AvandiaPHASE_31 trial
Active Trials
NCT00197132Completed18Est. Aug 2003
Novartis
NovartisBASEL, Switzerland
1 program
NateglinidePHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Novo NordiskLiraglutide
SandozNateglinide
SandozVildagliptin
GSKAvandia
OrsoBioTLC-3595 Dose 1
GenfitGFT505 80mg
GenentechBFKB8488A
Innovation PharmaceuticalsKetoconazole
Kite PharmaTenofovir disaproxil fumarate/emtricitabine/elvitegravir/cobicistat
SandozBVS857
AstraZenecaAtropine
IncyteINCB13739
Human BioSciencesPolyphenols
Physical SciencesCircuit training
Human BioSciencesOral Glucose Tolerance Test

Showing 15 of 21 trials with date data

Clinical Trials (21)

Total enrollment: 849 patients across 21 trials

The Effect of Liraglutide on Dietary Lipid Induced Insulin Resistance in Humans

Start: Mar 2013Est. completion: Nov 202397 patients
Phase 4Completed

Insulin Resistance and Vessel Function After Meals: Does Early Intervention Make a Difference?

Start: Jun 2003Est. completion: Mar 200670 patients
Phase 4Completed
NCT01122641SandozVildagliptin

The Vascular Effects of Vildagliptin in Insulin Resistant Individuals

Start: May 2010Est. completion: Aug 201415 patients
Phase 3Completed

Study In Patients With Insulin Resistance

Start: Oct 2002Est. completion: Aug 200318 patients
Phase 3Completed
NCT05665751OrsoBioTLC-3595 Dose 1

A Study Evaluating Daily Oral Doses of TLC-3595 in Participants With Insulin Resistance

Start: Mar 2023Est. completion: Dec 202476 patients
Phase 2Active Not Recruiting

Pilot Study With GFT505 (80mg) in Patients With Insulin Resistance and Abdominal Obesity

Start: Jan 2011Est. completion: Nov 201122 patients
Phase 2Completed

Study to Evaluate Safety, Tolerability, and Pharmacokinetics of BFKB8488A in Otherwise Healthy Overweight and Obese Participants With Likely Insulin Resistance

Start: Oct 2015Est. completion: Mar 201779 patients
Phase 1Completed

Hormonal Mechanisms of Sleep Restriction

Start: Oct 2014Est. completion: Oct 202340 patients
Phase 1Completed
NCT02203461Kite PharmaTenofovir disaproxil fumarate/emtricitabine/elvitegravir/cobicistat

Changes in Insulin Resistance in Healthy Volunteers on STRIBILD® Medication

Start: Jul 2014Est. completion: Oct 201430 patients
Phase 1Completed

Safety and Tolerability of BVS857 in Subjects With Insulin Resistance

Start: Mar 2011Est. completion: Mar 201243 patients
Phase 1Completed

Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity

Start: May 2007Est. completion: Nov 200812 patients
Phase 1Completed

A Study of the Effect of INCB013739 on Cortisone Reducing Enzyme Activity in Obese People Predisposed to Diabetes

Start: Nov 2006Est. completion: Mar 2007
Phase 1Completed

Effect of Dietary Polyphenols on Insulin Sensitivity

Start: Jan 2006Est. completion: Dec 200720 patients
Phase 1Completed

The Effect of 12-week Circuit Training on Insulin Sensitivity and Endothelial Function in Women With Insulin Resistance

Start: Aug 2020Est. completion: Jun 202549 patients
N/ACompleted
NCT04089332Human BioSciencesOral Glucose Tolerance Test

Insulin Resistance in Adolescents

Start: Oct 2019Est. completion: Jul 202223 patients
N/ACompleted

The Effect of Vasopressin on Glucose Regulation

Start: Apr 2016Est. completion: May 201760 patients
N/ACompleted

The Role of Milk Derived Peptides on Glycaemic Control

Start: Oct 2015Est. completion: Jun 20176 patients
N/ACompleted

New IR Biomarkers (Myokines) in Colombian People

Start: Aug 2014Est. completion: Dec 201681 patients
N/ACompleted

Timing Estrogen After MenoPaUSe

Start: Sep 2011Est. completion: Jan 201753 patients
N/ACompleted

Metabolic Studies- Interactions Between GH and Insulin in GHDA

Start: Dec 2007Est. completion: Feb 20108 patients
N/ACompleted
NCT00186537AbbottRosiglitazone

Comparing Tricor, Avandia, or Weight Loss to Lower Cardiovascular Risk Factors in People With High Triglycerides.

Start: Sep 2003Est. completion: Sep 200847 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
25 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.