Hyperuricemia

4
Pipeline Programs
4
Companies
14
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
0
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Sanofi
ELITEKApproved
rasburicase
Sanofi
intravenous2002

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Sanofi
SanofiPARIS, France
1 program
1
RasburicasePhase 45 trials
Active Trials
NCT04349306Completed50Est. Mar 2021
NCT01200485Completed55Est. Jul 2016
NCT01097369Terminated1Est. Feb 2010
+2 more trials
GS
Gilead SciencesFOSTER CITY, CA
1 program
1
ArhalofenatePhase 21 trial
Active Trials
NCT01416402Completed27Est. Oct 2011
Atom Therapeutics
Atom TherapeuticsChina - Suzhou
1 program
1
ABP-671Phase 11 trial
Active Trials
NCT04060173CompletedEst. Feb 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
SanofiRasburicase
SanofiRasburicase
SanofiRasburicase
SanofiRasburicase
SanofiRasburicase
Gilead SciencesArhalofenate
SanofiRasburicase
SanofiRasburicase
SanofiRasburicase
SanofiRasburicase
SanofiRasburicase
Atom TherapeuticsABP-671
SanofiRasburicase
SanofiRasburicase

Clinical Trials (14)

Total enrollment: 641 patients across 14 trials

Evaluate the Efficacy and Safety of Rasburicase (Fasturtec®) in the Prevention and Treatment of Hyperuricemia in Pediatric Patients With Non-Hodgkin's Lymphoma and Acute Leukemia

Start: May 2020Est. completion: Mar 202150 patients
Phase 4Completed

Rasburicase in Tumor Lysis Syndrome

Start: Feb 200633 patients
Phase 4Completed

Rasburicase for Treatment of Hyperuricemia in Children and Adolescence Patients With Tumor Lysis Syndrome

Start: Mar 2003Est. completion: Jan 200438 patients
Phase 4Completed

Rasburicase (Fasturtec) Registration Trial

Start: Oct 2007Est. completion: Jan 200910 patients
Phase 3Terminated

Rasburicase Versus Allopurinol in Tumor Patients at Risk for Hyperuricemia and Tumor Lysis Syndrome

Start: Apr 2004Est. completion: Dec 2007280 patients
Phase 3Completed

Open Label Safety/Efficacy Study of Arhalofenate in Combination With Febuxostat for Hyperuricemia in Gout Patients

Start: Aug 2011Est. completion: Oct 201127 patients
Phase 2Completed

Rasburicase in Patients at High Risk for Tumor Lysis Syndrome (TLS) During Cycle-2

Start: Apr 2011Est. completion: Jul 201655 patients
Phase 2Completed

Rasburicase for Hyperuricemia

Start: Jun 2005Est. completion: Apr 200630 patients
Phase 2Completed

Rasburicase as a Uricolytic Therapy for Hyperuricemia in Patients With Leukemia or Lymphoma

Start: Apr 2003Est. completion: Jun 200450 patients
Phase 2Completed

Rasburicase for the Treatment/Prevention of Hyperuricemia in Adult Patients With Relapsing Aggressive Non Hodgkin's Lymphoma

Start: Jul 2002Est. completion: Jan 200533 patients
Phase 2Terminated

Pharmacokinetic Evaluation of Rasburicase in Patients With Leukemia and/or Lymphoma at High Risk of TLS

Start: Jul 2006Est. completion: Apr 200718 patients
Phase 1/2Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ABP-671

Start: Sep 2019Est. completion: Feb 2020
Phase 1Completed

Elitek (Rasburicase) Immuno-Monitoring Study

Start: Feb 2010Est. completion: Feb 20101 patients
N/ATerminated

Rasburicase Treatment for Chemotherapy or Malignancy-Induced Hyperuricemia in Asthma/Allergy Patients

Start: Mar 2005Est. completion: Feb 201016 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 companies competing in this space