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Hypertriglyceridemia

35
Pipeline Programs
28
Companies
50
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
3
9
0
12
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

RNA Therapeutic
338%
Small Molecule
338%
Peptide
113%
Monoclonal Antibody
113%
+ 51 programs with unclassified modality

Competitive Landscape

27 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
10 programs
1
1
3
4
AntaraPhase 4
AntaraPhase 4
LovazaPhase 4
LovazaPhase 4
LovazaPhase 3
+5 more programs
Amarin
AmarinIreland - Dublin
3 programs
2
1
icosapent ethylPhase 44 trials
AMR101Phase 31 trial
AMR101Phase 31 trial
Active Trials
NCT01047501Completed702Est. Feb 2011
NCT01047683Completed229Est. Jul 2011
NCT04460651Completed4,093Est. Aug 2021
+3 more trials
Innovation Pharmaceuticals
1 program
1
VascepaPhase 41 trial
Active Trials
NCT02926027Completed80Est. Aug 2020
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
5 programs
2
3
AZD0585Phase 31 trial
EpanovaPhase 31 trial
Olive oil, 4gPhase 3
SimvastatinPhase 1Small Molecule1 trial
warfarinPhase 11 trial
Active Trials
NCT01486433Completed52Est. Mar 2012
NCT01431690Completed52Est. Oct 2011
NCT02463071Completed383Est. Mar 2017
+1 more trials
Medpace
MedpaceCINCINNATI, OH
3 programs
2
1
Olive oil, 4gPhase 31 trial
Diazoxide Choline Controlled-Release TabletPhase 21 trial
Diazoxide cholinePhase 21 trial
Active Trials
NCT01211847Completed44Est. Dec 2011
NCT00696475Completed80Est. Mar 2009
NCT01408303Completed646Est. Jun 2012
Mochida Pharmaceutical
2 programs
2
IcosapentPhase 31 trial
IcosapentPhase 31 trial
Active Trials
NCT04221217Completed120Est. Jul 2021
NCT03693131Completed580Est. Jun 2019
EMS
EMSBrazil - Hortolândia
1 program
1
Cipros 10 associationPhase 31 trial
Active Trials
NCT03527069Completed146Est. Jul 2025
Matinas Biopharma
Matinas BiopharmaBEDMINSTER, NJ
2 programs
1
1
Omega 3 pentaenoic acidPhase 21 trial
Drug Omega 3Phase 1/21 trial
Active Trials
NCT02310022Completed48Est. Aug 2016
NCT04177680Completed100Est. Jan 2021
Grace Medical
Grace MedicalTN - Memphis
2 programs
2
CaPrePhase 21 trial
CaPre™Phase 21 trial
Active Trials
NCT01455844Completed387Est. Aug 2014
NCT01516151Completed289Est. Sep 2013
Afimmune
AfimmuneIreland - Dublin
1 program
1
DS102Phase 23 trials
Active Trials
NCT04365400Terminated233Est. May 2022
NCT03452540Terminated9Est. Mar 2020
NCT03414541Completed49Est. Jan 2019
Response Pharmaceuticals
Response PharmaceuticalsVA - Falls Church
1 program
1
SLx-4090Phase 21 trial
Active Trials
NCT00562575Completed24Est. Feb 2008
OrsoBio
OrsoBioCA - Palo Alto
1 program
1
TLC-2716 Dose 1Phase 21 trial
Active Trials
NCT06564584Recruiting30Est. Sep 2025
Biocorp
BiocorpFrance - Issoire
1 program
1
JMT202 injectionPhase 1/21 trial
Active Trials
NCT07140809Recruiting48Est. Oct 2026
Arrowhead Pharmaceuticals
1 program
1
ARO-APOC3Phase 11 trial
Active Trials
NCT03783377Completed112Est. Feb 2021
Prevail Therapeutics
1 program
1
LY3875383Phase 11 trial
Active Trials
NCT05609825Terminated41Est. Jan 2024
NorthSea Therapeutics
NorthSea TherapeuticsNetherlands - Amsterdam
1 program
1
NST-1024Phase 11 trial
Active Trials
NCT04630366Completed96Est. Jun 2022
Ionis Pharmaceuticals
6 programs
IONIS ANGPTL3-LRxPHASE_11 trial
ISIS 678354PHASE_21 trial
ISIS apoC-III RxPHASE_21 trial
OlezarsenPHASE_2RNA Therapeutic1 trial
OlezarsenPHASE_3RNA Therapeutic1 trial
+1 more programs
Active Trials
NCT02709850Completed48Est. Jun 2017
NCT03385239Completed114Est. Feb 2020
NCT01529424Completed89Est. Jan 2014
+3 more trials
GSK
GSKLONDON, United Kingdom
6 programs
LovazaPHASE_1_21 trial
LovazaPHASE_31 trial
SimvastatinPHASE_3Small Molecule1 trial
AntaraPHASE_41 trial
AntaraPHASE_41 trial
+1 more programs
Active Trials
NCT00959842Completed15Est. Feb 2010
NCT00435045Completed245Est. Oct 2007
NCT00246701Completed256Est. Jun 2006
+3 more trials
Marea Therapeutics
Marea TherapeuticsCA - South SF
3 programs
MAR001PHASE_1_21 trial
MAR001PHASE_21 trial
MAR001PHASE_21 trial
Active Trials
NCT05896254Completed55Est. Dec 2024
NCT07028749Active Not Recruiting216Est. Dec 2026
NCT07199309Recruiting30Est. Nov 2026
Arctic Therapeutics
Arctic TherapeuticsIceland - Reykjavik
1 program
DHA-rich fish oil versus Phospholipid-rich fish oilN/A1 trial
Active Trials
NCT01908374Unknown32Est. Dec 2013
Doer Biologics
Doer BiologicsChina - Hangzhou
1 program
DR10624 Injection;N/A1 trial
Active Trials
NCT07050134Enrolling By Invitation40Est. Jul 2026
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
Docosahexenoic acidN/A1 trial
Active Trials
NCT00728338Completed40Est. Nov 2005
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
Fish oilN/A1 trial
Active Trials
NCT00804427Completed60Est. Apr 2010
Abbott
AbbottABBOTT PARK, IL
1 program
TricorN/A1 trial
Active Trials
NCT04650152Completed1,000Est. Nov 2021
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
LY3875383PHASE_1
Rhythm Pharmaceuticals
1 program
SetmelanotidePHASE_2Peptide1 trial
Active Trials
NCT03262610Completed1Est. Jan 2018
Regeneron
RegeneronTARRYTOWN, NY
1 program
evinacumabPHASE_2Monoclonal Antibody1 trial
Active Trials
NCT04863014Terminated21Est. Feb 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Amarinicosapent ethyl
Innovation PharmaceuticalsVascepa
GSKLovaza
GSKAntara
GSKAntara
Ionis PharmaceuticalsOlezarsen
EMSCipros 10 association
Amarinicosapent ethyl
Mochida PharmaceuticalIcosapent
Mochida PharmaceuticalIcosapent
Amarinicosapent ethyl
AstraZenecaAZD0585
Ionis PharmaceuticalsVolanesorsen
AstraZenecaEpanova
MedpaceOlive oil, 4g

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 53,294 patients across 50 trials

NCT04505098Amarinicosapent ethyl

A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults

Start: Aug 2020Est. completion: Dec 202239,600 patients
Phase 4Terminated

Effect of Vascepa on Improving Coronary Atherosclerosis in People With High Triglycerides Taking Statin Therapy

Start: Mar 2017Est. completion: Aug 202080 patients
Phase 4Completed

Boosted Lexiva With Lovaza Adjunctive Therapy in Hypertriglyceridemic, HIV-Infected Subjects

Start: Sep 2009Est. completion: Nov 201036 patients
Phase 4Completed

A Second Open-Label Extension of a Double-Blind, Parallel, Phase IV Study to Assess the Efficacy and Safety of Adjunctive Lovaza® (Formerly Known as Omacor®) Therapy in Hypertriglyceridemic Subjects Treated With Antara™

Start: Mar 2006Est. completion: May 200893 patients
Phase 4Completed

Evaluation of Efficacy and Safety of Omacor (Omega-3-acid Ethyl Esters) as Add-on Therapy in Hypertriglyceridemic Subjects Treated With Antara (Fenofibrate) Followed by an 8-week Extension

Start: Oct 2005Est. completion: Mar 2007167 patients
Phase 4Completed

A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease, or With Severe Hypertriglyceridemia

Start: Nov 2022Est. completion: Jun 20251,478 patients
Phase 3Completed
NCT03527069EMSCipros 10 association

Efficacy and Safety of Cipros 10 Association on the Isolated Hypertriglyceridemia and Dyslipidemia Treatment

Start: Jan 2021Est. completion: Jul 2025146 patients
Phase 3Completed
NCT04460651Amarinicosapent ethyl

PREPARE-IT. Prevention and Treatment of COVID19 With EPA in Subjects at Risk - Intervention Trial

Start: Aug 2020Est. completion: Aug 20214,093 patients
Phase 3Completed

Long-term Safety and Efficacy Study of MND-2119 in Patients With Hypertriglyceridemia

Start: Feb 2020Est. completion: Jul 2021120 patients
Phase 3Completed

Efficacy of MND-2119 in Participants With Hypertriglyceridemia

Start: Oct 2018Est. completion: Jun 2019580 patients
Phase 3Completed
NCT03428477Amarinicosapent ethyl

EPA for Metastasis Trial 2

Start: May 2018Est. completion: Apr 2026418 patients
Phase 3Active Not Recruiting

AZD0585 Phase III Long-term Study in Japan

Start: Jun 2015Est. completion: Mar 2017383 patients
Phase 3Completed

The COMPASS Study: A Study of Volanesorsen (Formally ISIS-APOCIIIRx) in Patients With Hypertriglyceridemia

Start: Feb 2015Est. completion: Jan 2017114 patients
Phase 3Completed

Epanova® for Lowering Very High Triglycerides II (EVOLVE II)

Start: Dec 2013Est. completion: Dec 2014379 patients
Phase 3Completed
NCT01408303MedpaceOlive oil, 4g

[E]PANOVA Combined With a [S]TATIN in [P]ATIENTS With HYPERT[R]IGLYCER[I]DEMIA to Reduce Non-HDL CHOLES[T]EROL

Start: Aug 2011Est. completion: Jun 2012646 patients
Phase 3Completed

Efficacy and Safety of AMR101 (Ethyl Icosapentate) in Patients With Fasting Triglyceride (Tg) Levels ≥ 500 and ≤ 2000 mg/dL

Start: Dec 2009Est. completion: Jul 2011229 patients
Phase 3Completed

Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL)

Start: Dec 2009Est. completion: Feb 2011702 patients
Phase 3Completed

Evaluation of Efficacy and Safety of Omacor, Co-Administered With Atorvastatin, in Subjects With Hypertriglyceridemia

Start: Feb 2007Est. completion: Oct 2007245 patients
Phase 3Completed
NCT00246701GSKSimvastatin

Evaluation of Efficacy and Safety of Combined Omacor (Omega-3-acid Ethyl Esters) and Simvastatin Therapy in Hypertriglyceridemic Subjects

Start: Nov 2005Est. completion: Jun 2006256 patients
Phase 3Completed

A Mechanistic Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Start: Sep 2025Est. completion: Nov 202630 patients
Phase 2Recruiting

Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Start: Jun 2025Est. completion: Dec 2026216 patients
Phase 2Active Not Recruiting
NCT06564584OrsoBioTLC-2716 Dose 1

Phase 2a Study of Safety, Tolerability, and Efficacy of TLC-2716 in Subjects With Hypertriglyceridemia and NAFLD

Start: Aug 2024Est. completion: Sep 202530 patients
Phase 2Recruiting

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia

Start: May 2022Est. completion: Dec 2023154 patients
Phase 2Completed

Efficacy and Safety of Evinacumab in Adult Patients With Severe Hypertriglyceridemia for the Prevention of Recurrent Acute Pancreatitis

Start: Jul 2021Est. completion: Feb 202321 patients
Phase 2Terminated

Assess Efficacy and Safety of Epeleuton in Patients With Hypertriglyceridemia and Type 2 Diabetes

Start: Oct 2020Est. completion: May 2022233 patients
Phase 2Terminated
NCT04177680Matinas BiopharmaOmega 3 pentaenoic acid

Pharmacodynamic Effects of a Free-Fatty Acid Formulation of Omega-3 Pentaenoic Acid in Adults With Hypertriglyceridemia

Start: Jun 2020Est. completion: Jan 2021100 patients
Phase 2Completed

Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis

Start: Nov 2018Est. completion: Mar 20209 patients
Phase 2Terminated

Study of ISIS 678354 (AKCEA-APOCIII-LRx) in Participants With Hypertriglyceridemia and Established Cardiovascular Disease (CVD)

Start: Jan 2018Est. completion: Feb 2020114 patients
Phase 2Completed

Safety And Efficacy Study Of Orally Administered DS102 In Patients With Chronic Obstructive Pulmonary Disease

Start: Sep 2017Est. completion: Jan 201949 patients
Phase 2Completed

Setmelanotide in a Single Patient With Partial Lipodystrophy

Start: Aug 2017Est. completion: Jan 20181 patients
Phase 2Completed

Safety, Tolerability, and Pharmacokinetic Study of ISIS ApoC-III Rx in Hypertriglyceridemia

Start: Feb 2012Est. completion: Jan 201489 patients
Phase 2Completed

Assess the Safety and Efficacy of NKPL66 (CaPre™) in the Treatment of Mild-to-high Hypertriglyceridemia

Start: Dec 2011Est. completion: Sep 2013289 patients
Phase 2Completed

TRIal For Efficacy of Capre on hyperTriglyceridemiA

Start: Sep 2011Est. completion: Aug 2014387 patients
Phase 2Completed
NCT01211847MedpaceDiazoxide Choline Controlled-Release Tablet

Efficacy Study of Diazoxide Choline to Treat Hypertriglyceridemia

Start: Oct 2010Est. completion: Dec 201144 patients
Phase 2Completed
NCT00696475MedpaceDiazoxide choline

Diazoxide Choline in Hypertriglyceridemia

Start: Jun 2008Est. completion: Mar 200980 patients
Phase 2Completed

Evaluation of Safety and Effects of SLx-4090 After Dosing for 14 Days in Subjects With High Triglycerides

Start: May 2007Est. completion: Feb 200824 patients
Phase 2Completed
NCT07140809BiocorpJMT202 injection

a Phase 1b/2a Study of JMT202 Injection in Participants With Hypertriglyceridemia

Start: Sep 2025Est. completion: Oct 202648 patients
Phase 1/2Recruiting

Study of MAR001 in Adults With Metabolic Dysfunction

Start: Jul 2023Est. completion: Dec 202455 patients
Phase 1/2Completed

A PK and PD Study of Two Formulations of Omega-3 One Gram Capsules

Start: Nov 2014Est. completion: Aug 201648 patients
Phase 1/2Completed

Effects of Lovaza on Lipoprotein Composition and Function in Mild Hypertriglyceridemia

Start: Sep 2009Est. completion: Feb 201015 patients
Phase 1/2Completed

A Study of LY3875383 in Healthy Participants and Participants With Hypertriglyceridemia

Start: Nov 2022Est. completion: Jan 202441 patients
Phase 1Terminated

A Phase 1, First Time in Humans Study of NST-1024

Start: Oct 2020Est. completion: Jun 202296 patients
Phase 1Completed

Study of ARO-APOC3 in Healthy Volunteers, Hypertriglyceridemic Patients and Patients With Familial Chylomicronemia Syndrome (FCS)

Start: Mar 2019Est. completion: Feb 2021112 patients
Phase 1Completed
NCT03885661Amarinicosapent ethyl

Vascepa to Accelerate Lipoprotein Uptake and Elimination

Start: Jan 2016Est. completion: Jun 202120 patients
Phase 1Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS ANGPTL3-LRx in Healthy Volunteers With Elevated Triglycerides and Participants With Familial Hypercholesterolemia

Start: Nov 2015Est. completion: Jun 201748 patients
Phase 1Completed

The Effect of Multiple Doses of Epanova® on the Multiple-Dose Pharmacokinetics of Simvastatin in Healthy Normal Subjects

Start: Nov 2011Est. completion: Mar 201252 patients
Phase 1Completed

Interaction of Epanova on Warfarin Pharmacokinetic and Anticoagulant Activity and Comparison of the Effects of Epanova and Lovaza on Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) After Low-fat Meals

Start: Aug 2011Est. completion: Oct 201152 patients
Phase 1Completed
NCT07050134Doer BiologicsDR10624 Injection;

A Trial to Evaluate the Efficacy and Safety of DR10624 in Patients With Hypertriglyceridemia and Carotid Atherosclerotic Plaque

Start: Jul 2025Est. completion: Jul 202640 patients
N/AEnrolling By Invitation

Study to Assess Tricor Therapy Effectiveness in Patients With Metabolic Syndrome (TRISTAN)

Start: Oct 2020Est. completion: Nov 20211,000 patients
N/ACompleted
NCT01908374Arctic TherapeuticsDHA-rich fish oil versus Phospholipid-rich fish oil

Bioavailability of EPA and DHA From Two Dietary Supplements

Start: Jul 2013Est. completion: Dec 201332 patients
N/AUnknown

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 53,294 patients
28 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.