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Haemophilia A

5
Pipeline Programs
8
Companies
26
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
4
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 26 programs with unclassified modality

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Biocorp
BiocorpFrance - Issoire
4 programs
3
1
Optivate 500IUPhase 41 trial
Optivate®Phase 31 trial
Optivate®Phase 31 trial
Optivate®Phase 31 trial
Active Trials
NCT02246894Completed
NCT02250482Completed
NCT02246868Completed
+1 more trials
Bayer
BayerLEVERKUSEN, Germany
2 programs
1
Recombinant Factor VIIIPhase 31 trial
Recombinant Factor VIIIN/A1 trial
Active Trials
NCT01436825Completed69Est. Jul 2015
NCT01311648Completed94Est. Oct 2020
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
17 programs
ConcizumabN/AMonoclonal Antibody1 trial
EsperoctN/A1 trial
No treatment givenN/A1 trial
No treatment givenN/A1 trial
Turoctocog alfaN/A1 trial
+12 more programs
Active Trials
NCT06285071Enrolling By Invitation23Est. Apr 2030
NCT05621746Recruiting100Est. Jun 2026
NCT03660774Completed563Est. Oct 2019
+14 more trials
Swedish Orphan Biovitrum
2 programs
ELOCTAN/A1 trial
Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With N/A1 trial
Active Trials
NCT03055611Completed201Est. Apr 2022
NCT03276130Completed2,300Est. Jan 2020
CSL Seqirus
CSL SeqirusUK - Maidenhead
1 program
Afstyla®N/A
CSL Behring
CSL BehringIL - Bradley
1 program
Afstyla®N/A1 trial
Active Trials
NCT04675541Completed62Est. Dec 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
BiocorpOptivate 500IU
Novo NordiskNNC0365-3769
Novo NordiskMim8
Novo NordiskNNC0365-3769
Novo Nordiskturoctocog alfa pegol
Novo NordiskTuroctocog alfa
BayerRecombinant Factor VIII
BiocorpOptivate®
BiocorpOptivate®
BiocorpOptivate®
Novo NordiskNNC0442-0344 A
Novo NordiskNNC0442-0344 A
Novo NordiskNNC0442-0344 A
Novo NordiskNNC0365-3769
Novo NordiskConcizumab

Showing 15 of 26 trials with date data

Clinical Trials (26)

Total enrollment: 5,041 patients across 26 trials

NCT01811875BiocorpOptivate 500IU

Post-Marketing Safety Study Following Long-Term Prophylactic OptivateTreatment in Subjects With Severe Haemophilia A

Start: Nov 2014Est. completion: Aug 20177 patients
Phase 4Terminated

A Research Study Looking at How Safe it is to Switch From Emicizumab to Mim8 in People With Haemophilia A (FRONTIER 5)

Start: Jun 2023Est. completion: Jul 202461 patients
Phase 3Completed

A Research Study Looking at Long-term Treatment With Mim8 in People With Haemophilia A (FRONTIER 4)

Start: Feb 2023Est. completion: Jun 2028451 patients
Phase 3Active Not Recruiting

A Research Study Investigating Mim8 in Adults and Adolescents With Haemophilia A With or Without Inhibitors

Start: Dec 2021Est. completion: Dec 2024281 patients
Phase 3Completed
NCT05082116Novo Nordiskturoctocog alfa pegol

Efficacy and Safety of Turoctocog Alfa Pegol (N8-GP) for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Chinese Patients With Haemophilia A (pathfinder10)

Start: Sep 2021Est. completion: Dec 202236 patients
Phase 3Completed

Evaluation of Safety Following Immune Tolerance Induction Treatment With Turoctocog Alfa in Patients With Haemophilia A Following Inhibitor Development in NN7170-4213 Trial

Start: Jun 2018Est. completion: Jun 20191 patients
Phase 3Terminated
NCT01311648BayerRecombinant Factor VIII

BAY81-8973 Pediatric Safety and Efficacy Trial

Start: Jun 2011Est. completion: Oct 202094 patients
Phase 3Completed

A Study to Investigate the Safety and Efficacy of Optivate® in Children Under 6 Years of Age With Haemophilia A.

Start: Nov 2003
Phase 3Completed

An Open Study to Investigate the Safety and Efficacy of Optivate® in Haemophilia A Patients Undergoing Surgery.

Start: Nov 2001
Phase 3Completed

An Open Study to Investigate the Safety and Efficacy of Optivate® in Severe Haemophilia A Patients.

Start: Sep 2001
Phase 3Completed

A Research Study Looking at How Food Intake Affects Inno8 in the Body of Healthy People

Start: Nov 2025Est. completion: Apr 202680 patients
Phase 1Recruiting

A Research Study Looking at How Different Doses of Study Medicine (Inno8) Work in the Body of People With Haemophilia A

Start: Oct 2025Est. completion: Feb 202730 patients
Phase 1Recruiting

A Study Looking at How Different Doses of Study Medicine (Inno8) Works in the Body of Healthy Men

Start: Sep 2024Est. completion: Mar 202695 patients
Phase 1Completed

A Study to Compare the Blood Levels of Mim8 in Healthy Men When Administered With the DV3407-C1 Pen Injector or a Syringe and Cartridge

Start: Jan 2023Est. completion: Oct 2023205 patients
Phase 1Completed

Post-Marketing Surveillance (All Case Surveillance) on Treatment With Alhemo® in Patients With Haemophilia A or Haemophilia B With Inhibitors

Start: Aug 2024Est. completion: Apr 203023 patients
N/AEnrolling By Invitation

An Observational Research Study of the Health of Joints in People With Haemophilia Taking the Medicine Esperoct

Start: Nov 2022Est. completion: Jun 2026100 patients
N/ARecruiting

Turoctocog Alfa in Haemophilic Italian Patients: Protection and Engagement in Recreational Activities

Start: Apr 2021Est. completion: Mar 202318 patients
N/ACompleted
NCT04334057Novo NordiskTuroctocog alfa pegol

Post-Marketing Surveillance (Use-results Surveillance) With Esperoct®

Start: Mar 2021Est. completion: Jan 202423 patients
N/ACompleted
NCT04682145Novo NordiskTuroctocog alfa pegol

Adverse Event Data Collection From the EUHASS Registry on Turoctocog Alfa Pegol

Start: Dec 2020Est. completion: Feb 202650 patients
N/AEnrolling By Invitation
NCT04574076Novo NordiskTuroctocog alfa pegol

A Study Following Males With Haemophilia A on Prophylaxis With Esperoct®

Start: Oct 2020Est. completion: Jun 202760 patients
N/AEnrolling By Invitation
NCT03741881Novo NordiskNo treatment given

A Study Following People With Haemophilia A and B, With or Without Inhibitors, When on Usual Treatment (Explorer™6)

Start: Dec 2018Est. completion: Oct 2021231 patients
N/ACompleted
NCT03276130Swedish Orphan BiovitrumManagement of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With

Management of Health-Related QoL Impairment, Including Pain, Depression and Anxiety, in People With Haemophilia A and B

Start: Oct 2018Est. completion: Jan 20202,300 patients
N/ACompleted
NCT03660774Novo NordiskNo treatment given

A Study of the Impact of Hemophilia and Its Treatment on Brain Development, Thinking and Behaviour in Children With Hemophilia

Start: Sep 2018Est. completion: Oct 2019563 patients
N/ACompleted

Register of Patients With haEmophilia A tReated With Afstyla®

Start: Sep 2018Est. completion: Dec 202462 patients
N/ACompleted

A Study to Evaluate the Real-world Usage and Effectiveness of Elocta and Alprolix in Patients With Haemophilia A or B

Start: May 2017Est. completion: Apr 2022201 patients
N/ACompleted
NCT01436825BayerRecombinant Factor VIII

Validation Study of a cOmputer Pharmacokinetic Tool to assIst in the Follow up Care of haeMophilia A Patients

Start: Oct 2011Est. completion: Jul 201569 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 5,041 patients
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.