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Glabellar Lines

20
Pipeline Programs
9
Companies
26
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
1
5
0
7
3
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Ipsen
DYSPORTApproved
botulinum toxin type a
Ipsen
Acetylcholine Release Inhibitor [EPC]injection2009
3M Part D

Competitive Landscape

9 companies ranked by most advanced pipeline stage

AbbVie
AbbVieNORTH CHICAGO, IL
10 programs
2
3
3
1
botulinum toxin type APhase 41 trial
AGN-151586Phase 31 trial
AGN-151586Phase 31 trial
AGN-151586Phase 31 trial
AGN-151586Phase 21 trial
+5 more programs
Active Trials
NCT01608672Completed207Est. Dec 2012
NCT06834789Completed132Est. Nov 2025
NCT05496335Completed90Est. May 2023
+7 more trials
Galderma
GaldermaTX - Dallas
3 programs
1
1
Dysport reconstituted at 1.5 mLPhase 41 trial
botulinum toxin neuromodulatorPhase 31 trial
AbobotulinumtoxinAN/A1 trial
Active Trials
NCT05089357Completed250Est. Dec 2023
NCT04225260Completed902Est. May 2021
NCT02718118Completed60Est. Oct 2016
Ipsen
IpsenChina - Tianjin
3 programs
1
Patient and Physician's Satisfaction After a Long Term Treatment of Glabellar Lines With Dysport®N/A1 trial
Botulinum toxin type APHASE_31 trial
Botulinum toxin type APHASE_31 trial
Active Trials
NCT02353897Completed150Est. Jul 2016
NCT02450526Completed520Est. Sep 2017
NCT02493946Completed600Est. Dec 2016
Biocorp
BiocorpFrance - Issoire
3 programs
2
1
CKDB-501APhase 31 trial
CKDB-501APhase 11 trial
CKDB-501BPhase 11 trial
Active Trials
NCT05292638Completed30Est. Jun 2022
NCT05428930Completed30Est. Oct 2022
NCT05804656Completed300Est. Nov 2023
Huons
HuonsKorea - Seongnam
3 programs
1
1
1
HU-045Phase 31 trial
HU-045Phase 21 trial
HU-014 InjPhase 1/21 trial
Active Trials
NCT02961673Completed57Est. Mar 2017
NCT05298449Completed50Est. Apr 2023
NCT06205797Recruiting312Est. Mar 2025
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
Botulinum Toxin Type APhase 3
JETEMA
JETEMAKorea - Gangwon
1 program
1
JTM201Phase 21 trial
Active Trials
NCT06246552Completed480Est. Jun 2025
Croma-Pharma
Croma-PharmaAustria - Leobendorf
2 programs
Letybo®N/A1 trial
Letybo®N/A1 trial
Active Trials
NCT07374965Completed20Est. Sep 2024
NCT07398755Completed29Est. Mar 2026
GSK
GSKLONDON, United Kingdom
1 program
Botulinum Toxin Type APHASE_31 trial
Active Trials
NCT00408785Completed256Est. May 2007

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
GaldermaDysport reconstituted at 1.5 mL
AbbViebotulinum toxin type A
HuonsHU-045
AbbVieAGN-151586
BiocorpCKDB-501A
AbbVieAGN-151586
AbbVieAGN-151586
Galdermabotulinum toxin neuromodulator
IpsenBotulinum toxin type A
IpsenBotulinum toxin type A
GSKBotulinum Toxin Type A
JETEMAJTM201
HuonsHU-045
AbbVieOnabotulinumtoxinA X
AbbVieFormulation A: OnabotulinumtoxinA

Showing 15 of 26 trials with date data

Clinical Trials (26)

Total enrollment: 6,773 patients across 26 trials

NCT02718118GaldermaDysport reconstituted at 1.5 mL

Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines

Start: Apr 2016Est. completion: Oct 201660 patients
Phase 4Completed
NCT01271452AbbViebotulinum toxin type A

Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines

Start: Sep 2010Est. completion: Apr 2011224 patients
Phase 4Completed

To Evaluate HU-045 in the Treatment of Glabellar Lines(Phase III)

Start: Jun 2024Est. completion: Mar 2025312 patients
Phase 3Recruiting

A Study to Evaluate AGN-151586 Intramuscular Injections in Adult Participants for Treatment of Glabellar Lines

Start: Mar 2024Est. completion: Feb 2025161 patients
Phase 3Completed

Efficacy and Safety of CKDB-501A in Subjects With Moderate-to-severe Glabellar Lines in Phase 3 Trial

Start: Apr 2023Est. completion: Nov 2023300 patients
Phase 3Completed

A Study to Assess Adverse Events and Change in Disease Activity of Intramuscular AGN-151586 Injection in Toxin-Naïve Adult Participants With Glabellar Lines

Start: Mar 2022Est. completion: Feb 2023309 patients
Phase 3Completed

A Study to Assess Adverse Events of Intramuscular AGN-151586 Injection in Adult Participants With Glabellar Lines

Start: Feb 2022Est. completion: Jun 2023986 patients
Phase 3Completed
NCT04225260Galdermabotulinum toxin neuromodulator

Long-term Treatment of Moderate to Severe Glabellar Lines and Lateral Canthal Lines

Start: Jan 2020Est. completion: May 2021902 patients
Phase 3Completed
NCT02493946IpsenBotulinum toxin type A

Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines

Start: Apr 2015Est. completion: Dec 2016600 patients
Phase 3Completed
NCT02450526IpsenBotulinum toxin type A

Dysport in the Treatment of Glabellar Lines in Chinese Subjects

Start: Apr 2015Est. completion: Sep 2017520 patients
Phase 3Completed
NCT00408785GSKBotulinum Toxin Type A

A Study Of BOTOX For The Treatment Of Glabellar Lines

Start: Nov 2006Est. completion: May 2007256 patients
Phase 3Completed

Clinical Trial to Evaluate the Safety and Efficacy of JTM201 to Treat Moderate or Severe Glabellar Lines

Start: Oct 2024Est. completion: Jun 2025480 patients
Phase 2Completed

Phase 2 of HU-045 in Glabellar Lines

Start: Mar 2022Est. completion: Apr 202350 patients
Phase 2Completed
NCT05100199AbbVieOnabotulinumtoxinA X

A Study to the Assess the Change in Condition and Adverse Events of OnabotulinumtoxinA X Injection in Adult Participants With Glabellar Lines

Start: Oct 2021Est. completion: Dec 2022328 patients
Phase 2Completed
NCT05013424AbbVieFormulation A: OnabotulinumtoxinA

A Study of OnabotulinumtoxinA X Injection in Adult Participants With Glabellar Lines

Start: Sep 2021Est. completion: Jul 202292 patients
Phase 2Completed

AGN-151586 Dose-Ranging Study for Treatment of Glabellar Lines

Start: Sep 2019Est. completion: Sep 2020198 patients
Phase 2Completed

The Safety and Efficacy Study of HU-014 Versus Botox® in Subject With Moderate to Severe Glabellar Lines

Start: Sep 2016Est. completion: Mar 201757 patients
Phase 1/2Completed

A Study to Assess the Adverse Events of Intramuscular Injections of AGN-151586 and OnabotulinumtoxinA in Adult Participants for the Change of Glabellar Lines (GL)

Start: Feb 2025Est. completion: Nov 2025132 patients
Phase 1Completed

A Study to Evaluate Sequential Administration of AGN-151586 and OnabotulinumtoxinA (BOTOX) Injections in Adult Participants for Treatment of Glabellar Lines

Start: Aug 2022Est. completion: May 202390 patients
Phase 1Completed

Safety and Efficacy of CKDB-501B in Subjects With Moderate-to-severe Glabellar Lines

Start: Jun 2022Est. completion: Oct 202230 patients
Phase 1Completed

Safety and Efficacy of CKDB-501A in Subjects With Moderate-to-severe Glabellar Lines

Start: Feb 2022Est. completion: Jun 202230 patients
Phase 1Completed

Prospective, Non-interventional Study Assessing Periorbital Rejuvenation Procedure

Start: Sep 2025Est. completion: Mar 202629 patients
N/ACompleted

A Prospective, Non-Interventional, Single-Centre Study Assessing the Efficacy of a Holistic Upper Face Treatment With Botulinum Neurotoxin A

Start: Jan 2024Est. completion: Sep 202420 patients
N/ACompleted
NCT05089357GaldermaAbobotulinumtoxinA

Non-interventional Study, Long Term Treatment on Glabellar Lines With Dysport® in Subjects of Chinese Origin

Start: Nov 2021Est. completion: Dec 2023250 patients
N/ACompleted
NCT02353897IpsenPatient and Physician's Satisfaction After a Long Term Treatment of Glabellar Lines With Dysport®

Patient and Physician's Satisfaction After a Long Term Treatment of Glabellar Lines With Dysport®

Start: Oct 2014Est. completion: Jul 2016150 patients
N/ACompleted
NCT01608672AbbViebotulinum toxin Type A

Long-Term Patient Satisfaction of Facial Aesthetic Treatment With BOTOX®

Start: Apr 2012Est. completion: Dec 2012207 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

7 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 6,773 patients
9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.