Fungal Infection

11
Pipeline Programs
8
Companies
50
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
7
1
2
0
0
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 13 programs with unclassified modality

Competitive Landscape

8 companies ranked by most advanced pipeline stage

GS
Gilead SciencesFOSTER CITY, CA
1 program
1
liposomal amphotericin BPhase 42 trials
Active Trials
NCT00451711Unknown60Est. Oct 2014
NCT00386997Terminated20Est. Sep 2007
M&
Merck & Co.RAHWAY, NJ
3 programs
1
2
caspofunginPhase 25 trials
caspofungin acetatePhase 25 trials
PosaconazolePhase 1Small Molecule5 trials
Active Trials
NCT00686621Approved For Marketing
NCT05065658Completed249Est. Aug 2023
NCT03717623Recruiting100Est. Dec 2025
+12 more trials
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
1
human lactoferrinPhase 1/21 trial
Active Trials
NCT00430469WithdrawnEst. Jun 2009
BP
Basilea PharmaceuticaSwitzerland - Allschwil
4 programs
4
APX001Phase 11 trial
APX001 single IV dosePhase 11 trial
APX001 single dose 1Phase 11 trial
[14C]-APX001 Oral SolutionPhase 11 trial
Active Trials
NCT04166669CompletedEst. Mar 2020
NCT02957929CompletedEst. Apr 2017
NCT02956499CompletedEst. Jul 2017
+1 more trials
Astellas
AstellasChina - Shenyang
2 programs
1
MicafunginPhase 11 trial
Invasive Fungal Infections Surveillance InitiativeN/A1 trial
Active Trials
NCT00177944Completed172Est. Aug 2012
NCT00842504Completed15Est. Dec 2009
Scynexis
ScynexisJERSEY CITY, NJ
1 program
1
[14C]-IbrexafungerpPhase 11 trial
Active Trials
NCT04307082CompletedEst. Jun 2020
CAGE Bio
CAGE BioCA - San Carlos
1 program
CGB-400 Topical GelN/A1 trial
Active Trials
NCT05202366UnknownEst. Sep 2022
Pfizer
PfizerNEW YORK, NY
1 program
Vfend Special Investigation For ProphylaxisN/A1 trial
Active Trials
NCT02674685Completed241Est. Jul 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.caspofungin
Merck & Co.Posaconazole
Merck & Co.caspofungin
Gilead Sciencesliposomal amphotericin B
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.caspofungin acetate
Merck & Co.caspofungin acetate
Merck & Co.Posaconazole
Merck & Co.caspofungin acetate

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 4,579 patients across 50 trials

Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants

Start: Aug 2019Est. completion: Dec 2025100 patients
Phase 4Recruiting

Dosing Obese With Noxafil® Under a Trial (DONUT)

Start: Nov 2017Est. completion: Sep 201824 patients
Phase 4Completed

Posaconazole as Salvage Therapy for Aspergillus Pulmonary Infection.

Start: Dec 20130
Phase 4Withdrawn

A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)

Start: Jan 2013Est. completion: Jan 201426 patients
Phase 4Terminated

Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease

Start: Jan 2012Est. completion: Nov 201440 patients
Phase 4Unknown

Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)

Start: Dec 2007Est. completion: Apr 200975 patients
Phase 4Completed

Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU)

Start: Aug 2007Est. completion: Mar 2010222 patients
Phase 4Completed
NCT00386997Gilead Sciencesliposomal amphotericin B

ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia

Start: Nov 2006Est. completion: Sep 200720 patients
Phase 4Terminated

Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101)

Start: Jul 2014Est. completion: Jan 2018116 patients
Phase 3Completed

Safety and Efficacy Study of Posaconazole vs. Fluconazole for Prevention of Invasive Fungal Infection (P05387 AM1)(COMPLETED)

Start: Nov 2008Est. completion: May 2010252 patients
Phase 3Completed

Posaconazole Treatment of Invasive Fungal Infection (IFI) (P05551)

Start: Nov 2008Est. completion: Mar 201063 patients
Phase 3Completed
NCT00717860Merck & Co.caspofungin acetate

A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED)

Start: Aug 2008Est. completion: Jul 2010121 patients
Phase 3Completed
NCT00635648Merck & Co.caspofungin acetate

A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066)

Start: Jan 2008Est. completion: May 201163 patients
Phase 3Completed

POS vs FLU for First Line Treatment of Coccidioidomycosis (Study P04558Am1)(COMPLETED)

Start: May 2007Est. completion: May 200916 patients
Phase 3Completed
NCT00548080Merck & Co.caspofungin acetate

Evaluate the Safety and Efficacy of Caspofungin Acetate as Empirical Therapy in Chinese Adults With Persistent Fever and Neutropenia (0991-055)

Start: Mar 2006Est. completion: Nov 2006131 patients
Phase 3Completed
NCT00250432Merck & Co.caspofungin acetate

A Multicenter, Randomized, Double-Blind, Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of 2 Dosing Regimens of an Antifungal Drug in the Treatment of Fungal Infections in Adults (0991-801)(COMPLETED)

Start: Jan 2006Est. completion: Mar 2008204 patients
Phase 3Completed
NCT00379964Merck & Co.caspofungin acetate

A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED)

Start: Jun 2005Est. completion: May 200650 patients
Phase 3Completed

Prophylaxis Trial of Posaconazole Versus Standard Azole Therapy for Neutropenic Patients (Study P01899)

Start: Jul 2002Est. completion: Apr 2005602 patients
Phase 3Completed

Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095)

Start: Apr 2001Est. completion: Mar 2007
Phase 3Completed

Prophylaxis Trial in High Risk Allogenic Stem Cell Transplant Recipients With Graft vs. Host Disease

Start: Jan 1999Est. completion: Feb 2003600 patients
Phase 3Completed

Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041)

Start: Dec 1998Est. completion: Mar 2002336 patients
Phase 3Completed

Universal Prophylaxis Versus Pre-emptive Therapy With Posaconazole Post-Lung Transplant

Start: Jul 2018Est. completion: Sep 2020140 patients
Phase 2Unknown

Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients

Start: Apr 2018Est. completion: Jul 202320 patients
Phase 2Completed

Safety, Tolerability, and Efficacy of Caspofungin Versus Amphotericin B Deoxycholate in the Treatment of Invasive Candidiasis in Neonates and Infants (MK-0991-064)

Start: Jan 2014Est. completion: Feb 201851 patients
Phase 2Terminated

Pharmacokinetic, Safety and Efficacy of Intermittent Application of Caspofungin for Antifungal Prophylaxis

Start: Apr 2011Est. completion: Oct 201325 patients
Phase 2Completed

A Study of Caspofungin (MK-0991) in Japanese Children and Adolescents With Documented Candida or Aspergillus Infections (MK-0991-074)

Start: Jul 2010Est. completion: Sep 201320 patients
Phase 2Completed

Caspofungin as Prophylaxis in High Risk Liver Transplantation Recipients

Start: May 2009Est. completion: Nov 201238 patients
Phase 2Unknown

A Study to Examine the Efficacy and Safety of Posaconazole When Introduced Early in the Treatment of Refractory Fungal Infections (P05090 AM2)

Start: Dec 2007Est. completion: Nov 201240 patients
Phase 2Completed
NCT00451711Gilead Sciencesliposomal amphotericin B

Intermittent Liposomal Amphotericin B Primary Prophylaxis

Start: May 2007Est. completion: Oct 201460 patients
Phase 2Unknown
NCT00330395Merck & Co.caspofungin acetate

Open, Pharmacokinetic Study of Caspofungin in Neonates and Infants (0991-058)

Start: May 2006Est. completion: Oct 200616 patients
Phase 2Completed
NCT00292071Merck & Co.caspofungin acetate

Open, Pharmacokinetic Study of Caspofungin Acetate in Immunocompromised Young Children With Febrile Neutropenia (0991-042)

Start: May 2004Est. completion: Jul 200616 patients
Phase 2Completed
NCT00083343Merck & Co.caspofungin acetate

Caspofungin for the Treatment of Non-blood Candida Infections (0991-045)

Start: May 2004Est. completion: Feb 200648 patients
Phase 2Completed
NCT00082524Merck & Co.caspofungin acetate

Documented Candida or Aspergillus Infections in Pediatric Patients (0991-043)

Start: Apr 2004Est. completion: Jul 200750 patients
Phase 2Completed

Prophylaxis With Caspofungin in High-Risk Liver Transplantation

Start: Oct 2003Est. completion: Mar 200770 patients
Phase 2Unknown
NCT00076869Merck & Co.caspofungin acetate

MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037)

Start: Jan 2003Est. completion: Aug 200555 patients
Phase 2Completed

PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)

Start: Jan 2001Est. completion: Mar 200298 patients
Phase 2Completed
NCT00430469AM-Pharmahuman lactoferrin

Safety of hLF1-11 for the Treatment of Infectious Complications Among HSCT Recipients

Start: Nov 2008Est. completion: Jun 2009
Phase 1/2Withdrawn
NCT04307082Scynexis[14C]-Ibrexafungerp

ADME Study of [14C]-Ibrexafungerp in Healthy Male Subjects

Start: Dec 2019Est. completion: Jun 2020
Phase 1Completed

A Drug-Drug Interaction Study of CYP3A4 Inhibition and Pan-CYP Induction on APX001

Start: Nov 2019Est. completion: Mar 2020
Phase 1Completed
NCT04804059Basilea Pharmaceutica[14C]-APX001 Oral Solution

A Study to Assess the Mass Balance Recovery and Metabolite Profile & Identification of [14C]-APX001 in Healthy Males

Start: Aug 2018Est. completion: Sep 2018
Phase 1Completed

Pharmacokinetics and Safety of Intravenous Posaconazole (MK-5592) in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-120)

Start: Dec 2017Est. completion: Nov 201870 patients
Phase 1Completed

Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Orally

Start: Oct 2016Est. completion: Apr 2017
Phase 1Completed

Study to Assess Safety, Tolerability and Pharmacokinetics of APX001 Administered by Intravenous Infusion to Healthy Subjects

Start: May 2016Est. completion: Jul 2017
Phase 1Completed

Pharmacokinetics and Safety of Oral Posaconazole (MK-5592)Tablets in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-117)

Start: May 2015Est. completion: May 201665 patients
Phase 1Completed

Pharmacokinetics and Safety of Posaconazole Tablet in Participants at High Risk for Invasive Fungal Infections (MK-5592-065/P05615)

Start: Jun 2009Est. completion: Feb 2012230 patients
Phase 1Completed

A Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children (P03579)

Start: Apr 2008Est. completion: Apr 2015142 patients
Phase 1Terminated

Alternate Day Micafungin: A PK Study in Pediatric Patients

Start: Jul 2007Est. completion: Dec 200915 patients
Phase 1Completed

Single Patient Treatment of Posaconazole in Invasive Fungal Infections (Study P05113)

N/AApproved For Marketing
NCT05202366CAGE BioCGB-400 Topical Gel

An Open-label Study Evaluating the Effectiveness of CGB-400 Topical Gel for Fungal Infection

Start: Feb 2022Est. completion: Sep 2022
N/AUnknown

Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients

Start: Mar 2020Est. completion: Aug 2023249 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 4,579 patients
8 companies competing in this space