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Fungal Infection

33
Pipeline Programs
13
Companies
25
Clinical Trials
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
7
1
6
0
10
9
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
14100%
+ 27 programs with unclassified modality

On Market (3)

Approved therapies currently available

Merck & Co.
CANCIDASApproved
caspofungin acetate
Merck & Co.
intravenous2001
55K Part D
Merck & Co.
NOXAFILApproved
posaconazole
Merck & Co.
oral2006
Merck & Co.
NOXAFIL POWDERMIX KITApproved
posaconazole
Merck & Co.
Azole Antifungal [EPC]oral2021

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
13 programs
3
3
5
2
PosaconazolePhase 4Small Molecule
PosaconazolePhase 4Small Molecule
MK0991, caspofungin acetate / Duration of Treatment:Phase 3
PosaconazolePhase 3Small Molecule
caspofungin acetatePhase 3
+8 more programs
MSD
MSDIreland - Ballydine
13 programs
3
3
5
2
PosaconazolePhase 4Small Molecule1 trial
PosaconazolePhase 4Small Molecule1 trial
MK0991, caspofungin acetate / Duration of Treatment:Phase 31 trial
PosaconazolePhase 3Small Molecule1 trial
caspofungin acetatePhase 31 trial
+8 more programs
Active Trials
NCT02387983Completed65Est. May 2016
NCT01075984Completed279Est. Nov 2012
NCT03336502Completed70Est. Nov 2018
+10 more trials
Merck & Co.
Merck & Co.RAHWAY, NJ
3 programs
1
PosaconazolePHASE_1Small Molecule
caspofunginPHASE_2
caspofungin acetatePHASE_2
Pfizer
PfizerNEW YORK, NY
2 programs
1
Prospective TDM ArmPhase 41 trial
Vfend Special Investigation For ProphylaxisN/A1 trial
Active Trials
NCT02674685Completed241Est. Jul 2019
NCT01416025Completed29Est. Dec 2014
Kite Pharma
Kite PharmaCA - El Segundo
1 program
1
liposomal amphotericin BPhase 41 trial
Active Trials
NCT00386997Terminated20Est. Sep 2007
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
1
human lactoferrinPhase 1/23 trials
Active Trials
NCT00509847Withdrawn0Est. Oct 2009
NCT00430469Withdrawn0Est. Jun 2009
NCT00509938Completed8Est. Nov 2006
Astellas
AstellasChina - Shenyang
2 programs
1
MicafunginPhase 11 trial
Invasive Fungal Infections Surveillance InitiativeN/A1 trial
Active Trials
NCT00177944Completed172Est. Aug 2012
NCT00842504Completed15Est. Dec 2009
CAGE Bio
CAGE BioCA - San Carlos
1 program
CGB-400 Topical GelN/A
Biocorp
BiocorpFrance - Issoire
1 program
CGB-400 Topical GelN/A1 trial
Active Trials
NCT05202366Completed15Est. Aug 2024
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
Fluconazole Pharmacokinetics in InfantsN/A1 trial
Active Trials
NCT00514358Completed55Est. Jun 2007
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
VoriconazoleN/ASmall Molecule1 trial
Active Trials
NCT01101386Completed10Est. Nov 2012
Scynexis
ScynexisJERSEY CITY, NJ
1 program
[14C]-IbrexafungerpPHASE_11 trial
Active Trials
NCT04307082Completed6Est. Jun 2020
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
1 program
liposomal amphotericin BPHASE_4

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
MSDPosaconazole
PfizerProspective TDM Arm
MSDPosaconazole
Kite Pharmaliposomal amphotericin B
MSDPosaconazole
MSDcaspofungin acetate
MSDcaspofungin acetate
MSDMK0991, caspofungin acetate / Duration of Treatment:
MSDcaspofungin acetate
MSDUniversal Posaconazole Prophylaxis
MSDcaspofungin
MSDcaspofungin acetate
AM-Pharmahuman lactoferrin
AM-Pharmahuman lactoferrin
AM-Pharmahuman lactoferrin

Showing 15 of 25 trials with date data

Clinical Trials (25)

Total enrollment: 1,695 patients across 25 trials

NCT01667107MSDPosaconazole

A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)

Start: Jan 2013Est. completion: Jan 201426 patients
Phase 4Terminated
NCT01416025PfizerProspective TDM Arm

A Trial Comparing Efficacy and Safety of Voriconazole Administered With Therapeutic Drug Monitoring vs. Standard Dosing

Start: Jan 2012Est. completion: Dec 201429 patients
Phase 4Completed
NCT00686543MSDPosaconazole

Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)

Start: Dec 2007Est. completion: Apr 200975 patients
Phase 4Completed
NCT00386997Kite Pharmaliposomal amphotericin B

ProphyALL - Study on the Safety of Liposomal Amphotericin B to Prevent Antifungal Infections in Elderly Patients With Acute Lymphoblastic Leukemia

Start: Nov 2006Est. completion: Sep 200720 patients
Phase 4Terminated
NCT00811642MSDPosaconazole

Posaconazole Treatment of Invasive Fungal Infection (IFI) (P05551)

Start: Nov 2008Est. completion: Mar 201063 patients
Phase 3Completed
NCT00717860MSDcaspofungin acetate

A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED)

Start: Aug 2008Est. completion: Jul 2010121 patients
Phase 3Completed
NCT00635648MSDcaspofungin acetate

A Study of Caspofungin Acetate (MK0991) for the Treatment of Esophageal Candidiasis or Invasive Candidiasis in Chinese Adults (MK-0991-066)

Start: Jan 2008Est. completion: May 201163 patients
Phase 3Completed
NCT00548080MSDMK0991, caspofungin acetate / Duration of Treatment:

Evaluate the Safety and Efficacy of Caspofungin Acetate as Empirical Therapy in Chinese Adults With Persistent Fever and Neutropenia (0991-055)

Start: Mar 2006Est. completion: Nov 2006131 patients
Phase 3Completed
NCT00379964MSDcaspofungin acetate

A 28 - 90 Days Study to Evaluate the Safety, Tolerability, and Efficacy of Caspofungin Injection as Empirical Therapy in Indian Adults With Persistent Fever and Neutropenia (0991-053)(COMPLETED)

Start: Jun 2005Est. completion: May 200650 patients
Phase 3Completed
NCT03561415MSDUniversal Posaconazole Prophylaxis

Universal Prophylaxis Versus Pre-emptive Therapy With Posaconazole Post-Lung Transplant

Start: Jul 2018Est. completion: Sep 2020140 patients
Phase 2Unknown
NCT01318148MSDcaspofungin

Pharmacokinetic, Safety and Efficacy of Intermittent Application of Caspofungin for Antifungal Prophylaxis

Start: Apr 2011Est. completion: Oct 201325 patients
Phase 2Completed
NCT00292071MSDcaspofungin acetate

Open, Pharmacokinetic Study of Caspofungin Acetate in Immunocompromised Young Children With Febrile Neutropenia (0991-042)

Start: May 2004Est. completion: Jul 200616 patients
Phase 2Completed
NCT00509847AM-Pharmahuman lactoferrin

A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis

Start: Feb 2009Est. completion: Oct 20090
Phase 1/2Withdrawn
NCT00430469AM-Pharmahuman lactoferrin

Safety of hLF1-11 for the Treatment of Infectious Complications Among HSCT Recipients

Start: Nov 2008Est. completion: Jun 20090
Phase 1/2Withdrawn
NCT00509938AM-Pharmahuman lactoferrin

Safety of a Single Dose of 5 mg of hLF1-11 Given to Autologous Haematopoietic Stem Cell Transplant Recipients

Start: Mar 2006Est. completion: Nov 20068 patients
Phase 1/2Completed
NCT04307082Scynexis[14C]-Ibrexafungerp

ADME Study of [14C]-Ibrexafungerp in Healthy Male Subjects

Start: Dec 2019Est. completion: Jun 20206 patients
Phase 1Completed
NCT03336502MSDPosaconazole

Pharmacokinetics and Safety of Intravenous Posaconazole (MK-5592) in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-120)

Start: Dec 2017Est. completion: Nov 201870 patients
Phase 1Completed
NCT02387983MSDPosaconazole

Pharmacokinetics and Safety of Oral Posaconazole (MK-5592)Tablets in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-117)

Start: May 2015Est. completion: May 201665 patients
Phase 1Completed
NCT01075984MSDPosaconazole

Pharmacokinetics, Safety, and Tolerability of Intravenous Posaconazole Solution Followed by Oral Posaconazole Suspension in Subjects at High Risk for Invasive Fungal Infections (P05520)

Start: Feb 2010Est. completion: Nov 2012279 patients
Phase 1Completed

Alternate Day Micafungin: A PK Study in Pediatric Patients

Start: Jul 2007Est. completion: Dec 200915 patients
Phase 1Completed
NCT05202366BiocorpCGB-400 Topical Gel

An Open-label Study Evaluating the Effectiveness of CGB-400 Topical Gel for Fungal Infection

Start: Feb 2022Est. completion: Aug 202415 patients
N/ACompleted
NCT02674685PfizerVfend Special Investigation For Prophylaxis

Vfend Special Investigation For Prophylaxis

Start: Mar 2016Est. completion: Jul 2019241 patients
N/ACompleted

Study of Cyclodextrin (SBECD) and Voriconazole Blood Concentrations During Continuous Dialysis

Start: May 2010Est. completion: Nov 201210 patients
N/ACompleted
NCT00514358Human BioSciencesFluconazole Pharmacokinetics in Infants

Fluconazole Pharmacokinetics in Infants

Start: Nov 2005Est. completion: Jun 200755 patients
N/ACompleted
NCT00177944AstellasInvasive Fungal Infections Surveillance Initiative

Invasive Fungal Infections Surveillance Initiative

Start: Aug 2005Est. completion: Aug 2012172 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

10 late-stage (Phase 3) programs, potential near-term approvals
13 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.