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Familial Mediterranean Fever

3
Pipeline Programs
4
Companies
4
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
3
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 3 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Unimed Pharma
Unimed PharmaSlovakia - Bratislava
2 programs
2
RPH-104Phase 21 trial
RPH-104Phase 21 trial
Active Trials
NCT05092776Active Not Recruiting84Est. Oct 2025
NCT05190991Recruiting60Est. Jan 2029
Sandoz
SandozAustria - Kundl
1 program
1
CanakinumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT01088880Completed10Est. Aug 2011
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Skin Autofluorescence MeasurementN/A1 trial
Active Trials
NCT07439341Not Yet RecruitingEst. Nov 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Unimed PharmaRPH-104
Unimed PharmaRPH-104
SandozCanakinumab
City TherapeuticsSkin Autofluorescence Measurement

Clinical Trials (4)

Total enrollment: 154 patients across 4 trials

Safety and Efficacy of RPH-104 Used to Prevent Recurrent Fever Attacks in Adult Patients With Colchicine Resistant or Colchicine Intolerant Familial Mediterranean Fever

Start: Oct 2021Est. completion: Jan 202960 patients
Phase 2Recruiting

Efficacy and Safety of RPH-104 for Resolution and Prevention of Recurring Attacks in Adult Subjects With Familial Mediterranean Fever With Resistance to or Intolerance of Colchicine

Start: Apr 2021Est. completion: Oct 202584 patients
Phase 2Active Not Recruiting

Efficacy and Safety of Canakinumab in Patients With Colchicine Resistant Familial Mediterranean Fever

Start: Apr 2010Est. completion: Aug 201110 patients
Phase 2Completed
NCT07439341City TherapeuticsSkin Autofluorescence Measurement

AGE and CALLY Index in Familial Mediterranean Fever

Start: Feb 2026Est. completion: Nov 2026
N/ANot Yet Recruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 154 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.