Facioscapulohumeral Muscular Dystrophy

3
Pipeline Programs
3
Companies
4
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
2
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

M&
Merck & Co.RAHWAY, NJ
1 program
1
ACE-083Phase 21 trial
Active Trials
NCT03943290TerminatedEst. Mar 2020
aTyr Pharma
aTyr PharmaSAN DIEGO, CA
2 programs
2
ATYR1940Phase 1/21 trial
ATYR1940Phase 1/21 trial
Active Trials
NCT02531217Completed9Est. May 2016
NCT02836418Completed8Est. Apr 2017
Dyne Therapeutics
1 program
FSHD-specific functional rating scaleN/A1 trial
Active Trials
NCT03458832RecruitingEst. Dec 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Merck & Co.ACE-083
aTyr PharmaATYR1940
aTyr PharmaATYR1940
Dyne TherapeuticsFSHD-specific functional rating scale

Clinical Trials (4)

Total enrollment: 17 patients across 4 trials

Extension Study to Evaluate the Long-Term Effects of ACE-083 in Patients With Facioscapulohumeral Muscular Dystrophy (FSHD) and Charcot-Marie Tooth (CMT) Disease Types 1 and X (CMT1 and CMTX)

Start: May 2019Est. completion: Mar 2020
Phase 2Terminated

Study to Evaluate the Long-Term Safety, Tolerability, and Biological Activity of ATYR1940 in Participants With Limb Girdle and Facioscapulohumeral Muscular Dystrophy (FSHD)

Start: Jul 2016Est. completion: Apr 20178 patients
Phase 1/2Completed

Safety, Tolerability, Pharmacokinetics (PK), and Activity of ATYR1940 in Participants With Muscular Dystrophy - Study Extension

Start: Aug 2015Est. completion: May 20169 patients
Phase 1/2Completed
NCT03458832Dyne TherapeuticsFSHD-specific functional rating scale

Clinical Trial Readiness to Solve Barriers to Drug Development in FSHD

Start: Mar 2018Est. completion: Dec 2027
N/ARecruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 17 patients
3 companies competing in this space