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Essential Tremor

13
Pipeline Programs
24
Companies
50
Clinical Trials
6 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
1
6
1
0
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

23 companies ranked by most advanced pipeline stage

Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
3 programs
2
1
MemantinePhase 41 trial
PerampanelPhase 21 trial
ZonisamidePhase 21 trial
Active Trials
NCT02668146Unknown16Est. Jun 2017
NCT00223743Completed25
NCT00439699Completed16Est. Dec 2009
Pfizer
PfizerNEW YORK, NY
2 programs
1
1
PregabalinPhase 41 trial
pregabalinPhase 11 trial
Active Trials
NCT00646451Completed20Est. Dec 2008
NCT00584376Completed29Est. Nov 2010
Sage Therapeutics
Sage TherapeuticsMA - Cambridge
4 programs
3
1
SAGE-324Phase 2/31 trial
SAGE-324Phase 21 trial
SAGE-324Phase 21 trial
SAGE-547Phase 21 trial
Active Trials
NCT04305275Completed69Est. Feb 2021
NCT05173012Completed146Est. May 2024
NCT02277106Completed25Est. Aug 2015
+1 more trials
Neurocrine Biosciences
1 program
1
NBI-827104Phase 21 trial
Active Trials
NCT04880616Completed31Est. Jun 2022
Essential Pharmaceuticals
1 program
1
CBD/THCPhase 1/21 trial
Active Trials
NCT03805750Completed7Est. Nov 2020
Insightec
InsightecFL - Miami
9 programs
2
ExAblate Transcranial MRgFUS SystemPhase 11 trial
ExAblate Transcranial MRgFUS SystemPhase 11 trial
ExAblateN/A1 trial
Exablate Model 4000 Type 1.0/1.1N/A1 trial
Exablate Neuro Type 1.0 System with Echo FocusingN/A1 trial
+4 more programs
Active Trials
NCT03465761Completed7Est. Nov 2025
NCT04112381Active Not Recruiting51Est. Jun 2026
NCT05089786Withdrawn0Est. Feb 2025
+6 more trials
Cala Health
Cala HealthCA - San Mateo
6 programs
Cala DeviceN/A1 trial
Cala ONE DeviceN/A1 trial
Cala ONE deviceN/A1 trial
Cala TWON/A1 trial
Cala TWO stimulatorN/A1 trial
+1 more programs
Active Trials
NCT05480215Completed20Est. Dec 2021
NCT02629614Completed93Est. Nov 2016
NCT03152136Completed62Est. Mar 2018
+3 more trials
Medtronic
MedtronicNJ - Phillipsburg
5 programs
Active biphasic pulse stimulation---Home SettingsN/A1 trial
Conventional AC-PC based implantation of ACTIVA INS DBS systemN/A1 trial
Deep brain stimulationN/A1 trial
Medtronic Summit RechargableN/A1 trial
Responsive deep brain stimulationN/A1 trial
Active Trials
NCT03811405Completed12Est. Jun 2025
NCT02491554Unknown24Est. Jun 2022
NCT02649166Active Not Recruiting20Est. Jun 2027
+2 more trials
Precision BioSciences
4 programs
10 mg PRAX-114, 20 mg PRAX-114, and PlaceboPHASE_2
100 mg PRAX-944PHASE_2
Part A: 20 and 40 mg PRAX-944PHASE_2
60 mg ulixacaltamidePHASE_3
Praxis Precision Medicines
4 programs
10 mg PRAX-114, 20 mg PRAX-114, and PlaceboPHASE_21 trial
100 mg PRAX-944PHASE_21 trial
Part A: 20 and 40 mg PRAX-944PHASE_21 trial
60 mg ulixacaltamidePHASE_31 trial
Active Trials
NCT05387642Withdrawn0Est. Jun 2022
NCT05021991Completed133Est. Feb 2024
NCT05021978Completed24Est. Mar 2022
+1 more trials
Boston Scientific
Boston ScientificCA - Valencia
3 programs
ContinuousN/A1 trial
DBS programingN/A1 trial
Deep Brain Stimulation SystemsN/A1 trial
Active Trials
NCT07302867Not Yet Recruiting5Est. Apr 2028
NCT06325852Recruiting15Est. Jan 2027
NCT04032470Recruiting500Est. Dec 2029
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
3 programs
CX-8998PHASE_21 trial
JZP385PHASE_21 trial
Sodium OxybatePHASE_21 trial
Active Trials
NCT03101241Completed95Est. Jul 2018
NCT05122650Completed420Est. May 2024
NCT00598078Completed19Est. Dec 2008
Great Lakes NeuroTechnologies
2 programs
Adaptive Portable Essential Tremor MonitorN/A1 trial
Kinesia HomeViewN/A1 trial
Active Trials
NCT01602042Completed20Est. Nov 2012
NCT01978080Completed39
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
2 programs
Alternating stimulationN/A1 trial
Deep brain stimulation of the VIM Thalamic nucleiN/A1 trial
Active Trials
NCT02947841Completed22Est. Jul 2017
NCT04828798Recruiting24Est. Oct 2029
Encora Therapeutics
2 programs
Encora PulseN/A1 trial
Encora Therapeutics Tremor Reduction DeviceN/A1 trial
Active Trials
NCT07078422Recruiting80Est. Jun 2026
NCT06343285Completed71Est. Nov 2024
Fasikl
FasiklMN - Minneapolis
2 programs
FelixN/A1 trial
Felix NeuroAI WristbandN/A1 trial
Active Trials
NCT05842434Completed40Est. Nov 2023
NCT06235190Active Not Recruiting126Est. Nov 2025
Biogen
BiogenCAMBRIDGE, MA
2 programs
SAGE-217PHASE_21 trial
SAGE-324PHASE_2
Active Trials
NCT02978781Completed34Est. Dec 2017
Abbott
AbbottABBOTT PARK, IL
1 program
Clinician programmer electrode screening mode toolN/A1 trial
Active Trials
NCT03794661Completed8Est. Dec 2020
GE HealthCare
1 program
DaTscan™ - Non-Caucasian ParticipantsN/A1 trial
Active Trials
NCT01952678Completed204Est. May 2016
Purdue Pharma
Purdue PharmaCT - Stamford
1 program
Environmental Epidemiology of Essential TremorN/A1 trial
Active Trials
NCT04576676Completed1,497Est. Jul 2023
BlueWind Medical
BlueWind MedicalIsrael - Herzliya
1 program
Stimulation procedureN/A1 trial
Active Trials
NCT01940406Withdrawn0Est. Dec 2013
Biocorp
BiocorpFrance - Issoire
1 program
Transcranial temporal interference stimulationN/A1 trial
Active Trials
NCT07531238Not Yet Recruiting6Est. May 2027
Ortho Development
1 program
topiramatePHASE_31 trial
Active Trials
NCT00236496Completed223Est. Feb 2004

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
PfizerPregabalin
Angeles TherapeuticsMemantine
Praxis Precision Medicines60 mg ulixacaltamide
Ortho Developmenttopiramate
Sage TherapeuticsSAGE-324
Praxis Precision Medicines10 mg PRAX-114, 20 mg PRAX-114, and Placebo
Sage TherapeuticsSAGE-324
Jazz PharmaceuticalsJZP385
Praxis Precision Medicines100 mg PRAX-944
Neurocrine BiosciencesNBI-827104
Sage TherapeuticsSAGE-324
Praxis Precision MedicinesPart A: 20 and 40 mg PRAX-944
Jazz PharmaceuticalsCX-8998
BiogenSAGE-217
Angeles TherapeuticsPerampanel

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 5,884 patients across 50 trials

Pregabalin (Lyrica) for the Treatment of Essential Tremor

Start: Dec 2007Est. completion: Nov 201029 patients
Phase 4Completed

A Pilot Clinical Trial Of Memantine for Essential Tremor

Start: Feb 2007Est. completion: Dec 200916 patients
Phase 4Completed

Essential 3 - Decentralized, Phase 3 Study Evaluating the Safety and Efficacy of Ulixacaltamide in Essential Tremor (ET)

Start: Nov 2023Est. completion: Dec 20261,000 patients
Phase 3Enrolling By Invitation

A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause.

Start: Oct 2001Est. completion: Feb 2004223 patients
Phase 3Completed

A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor

Start: Jun 2022Est. completion: Sep 202497 patients
Phase 2/3Terminated
NCT05387642Praxis Precision Medicines10 mg PRAX-114, 20 mg PRAX-114, and Placebo

A Clinical Trial of PRAX-114 in Participants With Essential Tremor

Start: Apr 2022Est. completion: Jun 20220
Phase 2Withdrawn

Study to Evaluate SAGE-324 in Participants With Essential Tremor

Start: Jan 2022Est. completion: May 2024146 patients
Phase 2Completed

A Study To Assess the Safety and Efficacy of JZP385 in the Treatment of Adults With Moderate to Severe Essential Tremor (ET)

Start: Dec 2021Est. completion: May 2024420 patients
Phase 2Completed

A Clinical Trial of 2 Doses of PRAX-944 in Participants With Essential Tremor

Start: Oct 2021Est. completion: Feb 2024133 patients
Phase 2Completed

Safety, Efficacy, and Tolerability of NBI-827104 for the Treatment of Essential Tremor

Start: Apr 2021Est. completion: Jun 202231 patients
Phase 2Completed

A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor

Start: May 2020Est. completion: Feb 202169 patients
Phase 2Completed
NCT05021978Praxis Precision MedicinesPart A: 20 and 40 mg PRAX-944

A Clinical Trial of PRAX-944 in Participants With Essential Tremor

Start: Mar 2020Est. completion: Mar 202224 patients
Phase 2Completed

A Phase 2 RCT Study of CX-8998 for Essential Tremor

Start: Aug 2017Est. completion: Jul 201895 patients
Phase 2Completed

A Study to Evaluate SAGE-217 in Participants With Essential Tremor

Start: Mar 2017Est. completion: Dec 201734 patients
Phase 2Completed

An Efficacy/Safety Study of Perampanel for Reducing Essential Tremor

Start: Oct 2015Est. completion: Jun 201716 patients
Phase 2Unknown

Evaluate SAGE-547 in Participants With Essential Tremor

Start: Sep 2014Est. completion: Aug 201525 patients
Phase 2Completed

Multiple-dose,Double-blind,Placebo-controlled Study of Sodium Oxybate in Patients With Essential Tremor

Start: Dec 2007Est. completion: Dec 200819 patients
Phase 2Completed

A Safety/Efficacy Trial of Zonisamide for Essential Tremor

Start: Nov 200425 patients
Phase 2Completed

Trial of Cannabis for Essential Tremor

Start: Jan 2019Est. completion: Nov 20207 patients
Phase 1/2Completed
NCT02037217InsightecExAblate Transcranial MRgFUS System

ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential Tremor

Start: Feb 2011Est. completion: Jan 201410 patients
Phase 1Completed
NCT01304758InsightecExAblate Transcranial MRgFUS System

ExAblate Transcranial MR Guided Focused Ultrasound in the Treatment of Essential Tremor

Start: Jan 2011Est. completion: Oct 201215 patients
Phase 1Completed

Pregabalin in the Treatment of Essential Tremor

Start: Jun 2006Est. completion: Dec 200820 patients
Phase 1Completed
NCT07531238BiocorpTranscranial temporal interference stimulation

Transcranial Temporal Interference Stimulation (tTIS) To Modulate Essential Tremor

Start: May 2026Est. completion: May 20276 patients
N/ANot Yet Recruiting

Neuromodulation Strategies for Treatment-Resistant Essential Tremor Using Chronos™ DBS

Start: Apr 2026Est. completion: Apr 20285 patients
N/ANot Yet Recruiting
NCT06974916InsightecStaged bilateral Exablate thalamotomy

EMBRACE Tremor BiFUS

Start: Apr 2025Est. completion: Jan 2028100 patients
N/ARecruiting

Home Use Study of Targeted Mechanical Stimulation for Tremor Relief

Start: Jan 2025Est. completion: Jun 202680 patients
N/ARecruiting

Directional Bilateral Thalamic Patterned Stimulation (Chronos)

Start: Jul 2024Est. completion: Jan 202715 patients
N/ARecruiting
NCT06235190FasiklFelix NeuroAI Wristband

Assessment of the Safety and Efficacy of the Felix NeuroAI Wristband in Essential Tremor

Start: Feb 2024Est. completion: Nov 2025126 patients
N/AActive Not Recruiting
NCT06343285Encora TherapeuticsEncora Therapeutics Tremor Reduction Device

Upper Limb Tremor Reduction in Essential Tremor Patients

Start: Jan 2024Est. completion: Nov 202471 patients
N/ACompleted

Pilot Study of the Felix System in Patients With Essential Tremor and Parkinson's Tremor

Start: Jun 2023Est. completion: Nov 202340 patients
N/ACompleted
NCT05089786InsightecExablate Neuro Type 1.0 System with Echo Focusing

Echo-Focusing in Patients With Treatment-Resistant Neurologic and Psychiatric Indications (EF001)

Start: Dec 2022Est. completion: Feb 20250
N/AWithdrawn

Symptomatic Relief of Action Tremor With Cala Trio Using Trio+ Bands

Start: Oct 2021Est. completion: Dec 202120 patients
N/ACompleted

RWE Study Utilizing the Cala Trio Device in Patients With Essential Tremor

Start: Apr 2021Est. completion: Mar 2024276 patients
N/ACompleted
NCT04828798Oregon TherapeuticsDeep brain stimulation of the VIM Thalamic nuclei

Directional Versus Nondirectional DBS for ET

Start: Apr 2021Est. completion: Oct 202924 patients
N/ARecruiting
NCT03811405MedtronicActive biphasic pulse stimulation---Home Settings

Physiology, Imaging and Modeling of Essential Tremor

Start: Apr 2021Est. completion: Jun 202512 patients
N/ACompleted
NCT04576676Purdue PharmaEnvironmental Epidemiology of Essential Tremor

Environmental Epidemiology of Essential Tremor

Start: Jul 2020Est. completion: Jul 20231,497 patients
N/ACompleted
NCT04112381InsightecExablate Model 4000 Type 1.0/1.1

Bilateral Treatment of Medication Refractory Essential Tremor

Start: Jun 2020Est. completion: Jun 202651 patients
N/AActive Not Recruiting
NCT04212780MedtronicMedtronic Summit Rechargable

Dual Lead Thalamic Deep Brain Recording (DBR)-DBS Interface for Closed Loop Control of Severe Essential Tremor

Start: Dec 2019Est. completion: Dec 202910 patients
N/ARecruiting
NCT04032470Boston ScientificDeep Brain Stimulation Systems

Boston Scientific Registry of Deep Brain Stimulation for Treatment of Essential Tremor (ET)

Start: Oct 2019Est. completion: Dec 2029500 patients
N/ARecruiting
NCT03794661AbbottClinician programmer electrode screening mode tool

Evaluation of the Infinity Deep Brain Stimulation Electrode Screening Mode Tool

Start: Jun 2019Est. completion: Dec 20208 patients
N/ACompleted
NCT03778060Cala HealthCala TWO stimulator

Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study

Start: Feb 2019Est. completion: Dec 202620 patients
N/AActive Not Recruiting

Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor

Start: Jan 2019Est. completion: Nov 20257 patients
N/ACompleted

Prospective Study for Symptomatic Relief of ET With Cala Therapy

Start: Dec 2018Est. completion: May 2019263 patients
N/ACompleted
NCT03051178MedtronicResponsive deep brain stimulation

Wearable Sensor for Responsive DBS for ET

Start: Sep 2018Est. completion: Sep 202117 patients
N/ACompleted
NCT03152136Cala HealthCala ONE device

A Pilot Study of the Cala ONE Device for Essential Tremor

Start: Jul 2017Est. completion: Mar 201862 patients
N/ACompleted
NCT02649166MedtronicDeep brain stimulation

Responsive Deep Brain Stimulator for Essential Tremor

Start: Feb 2017Est. completion: Jun 202720 patients
N/AActive Not Recruiting
NCT02947841Oregon TherapeuticsAlternating stimulation

The Effectiveness of Alternating Stimulation in Preventing Tolerance in Essential Tremor Patients

Start: Oct 2016Est. completion: Jul 201722 patients
N/ACompleted
NCT02629614Cala HealthCala ONE Device

Cala ONE Device for Essential Tremor

Start: Apr 2016Est. completion: Nov 201693 patients
N/ACompleted
NCT02491554MedtronicConventional AC-PC based implantation of ACTIVA INS DBS system

Deep braIn Stimulation for Tremor TractographIC Versus Traditional

Start: Aug 2015Est. completion: Jun 202224 patients
N/AUnknown
NCT02289560InsightecTranscranial ExAblate

Continued Access Protocol: ExAblate Transcranial MR Guided Focused Ultrasound for the Treatment of Essential Tremors

Start: Apr 2015Est. completion: Mar 202361 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 actively recruiting trials targeting 5,884 patients
24 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.