Ependymoma

3
Pipeline Programs
3
Companies
15
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
150%
Small Molecule
150%
+ 1 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Astellas
AstellasChina - Shenyang
1 program
1
ErlotinibPhase 2Small Molecule5 trials
Active Trials
NCT02588261Terminated530Est. Dec 2017
NCT02495233Terminated10Est. Sep 2016
NCT01927744Completed55Est. Jan 2025
+2 more trials
Nektar Therapeutics
Nektar TherapeuticsSAN FRANCISCO, CA
1 program
1
NivolumabPhase 1/2Monoclonal Antibody
Plus Therapeutics
1 program
1
Rhenium-186 NanoliposomePhase 11 trial
Active Trials
NCT07061626Not Yet Recruiting56Est. Mar 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib
Plus TherapeuticsRhenium-186 Nanoliposome
AstellasErlotinib
AstellasErlotinib
AstellasErlotinib

Clinical Trials (15)

Total enrollment: 2,041 patients across 15 trials

A Study of ASP8273 vs. Erlotinib or Gefitinib in First-line Treatment of Patients With Stage IIIB/IV Non-small Cell Lung Cancer Tumors With EGFR Activating Mutations

Start: Feb 2016Est. completion: Dec 2017530 patients
Phase 3Terminated

Erlotinib Prevention of Oral Cancer (EPOC)

Start: Nov 2006Est. completion: Jun 2018303 patients
Phase 3Completed

OSI-774 (Tarceva) in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

Start: Nov 2001Est. completion: Jan 2004731 patients
Phase 3Completed

Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical Resection

Start: Dec 2013Est. completion: Jan 202555 patients
Phase 2Completed

Erlotinib Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Start: May 2013Est. completion: Oct 201829 patients
Phase 2Completed

Stereotactic Radiosurgery or Other Local Ablation Then Erlotinib in Epidermal Growth Factor Receptor (EGFR)

Start: Dec 2012Est. completion: Mar 201932 patients
Phase 2Completed

Single-agent Erlotinib in Patients Previously Treated With Oral Etoposide in Protocol OSI-774-205

Start: May 2011Est. completion: Sep 20124 patients
Phase 2Terminated

Erlotinib Versus Oral Etoposide in Patients With Recurrent or Refractory Pediatric Ependymoma

Start: Sep 2010Est. completion: Nov 201225 patients
Phase 2Terminated

Erlotinib (Tarceva) as a Single Agent or Intercalated With Combination Chemotherapy in Patients With EGFR Positive NSCLC

Start: Jan 2006Est. completion: Mar 2009143 patients
Phase 2Completed

Erlotinib (Tarceva (Trademark), OSI-774) in Treating Patients With Advanced Non-Small Cell Lung Cancer

Start: Nov 2003Est. completion: Mar 200743 patients
Phase 2Completed

A Study of ASP2215 in Combination With Erlotinib in Subjects With Epidermal Growth Factor Receptor (EGFR) Activating Mutation-Positive (EGFRm+) Advanced Non-Small-Cell Lung Cancer (NSCLC) Who Have Acquired Resistance to an EGFR Tyrosine Kinase Inhibitor (TKI)

Start: Sep 2015Est. completion: Sep 201610 patients
Phase 1/2Terminated
NCT07061626Plus TherapeuticsRhenium-186 Nanoliposome

Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma

Start: Sep 2025Est. completion: Mar 202756 patients
Phase 1Not Yet Recruiting

Low Dose Daily Erlotinib in Combination With High Dose Twice Weekly Erlotinib in Patients With EGFR-Mutant Lung Cancer

Start: Oct 2013Est. completion: Nov 201853 patients
Phase 1Completed

Study of Erlotinib and Metformin in Triple Negative Breast Cancer

Start: Jul 2012Est. completion: Jun 20168 patients
Phase 1Completed

Erlotinib, Gemcitabine and Nab-Paclitaxel in Advanced Pancreatic Cancer

Start: Feb 2010Est. completion: Jan 201219 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 companies competing in this space