Drug Interaction Potentiation

5
Pipeline Programs
3
Companies
6
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
0
0
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
5100%
+ 1 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Akebia Therapeutics
Akebia TherapeuticsCAMBRIDGE, MA
4 programs
4
VadadustatPhase 1Small Molecule1 trial
VadadustatPhase 1Small Molecule1 trial
VadadustatPhase 1Small Molecule1 trial
vadadustatPhase 1Small Molecule1 trial
Active Trials
NCT03801733CompletedEst. Nov 2018
NCT03801759CompletedEst. Sep 2018
NCT03789032CompletedEst. Nov 2018
+1 more trials
Corcept Therapeutics
Corcept TherapeuticsCA - Redwood City
1 program
1
Mifepristone 300 MGPhase 11 trial
Active Trials
NCT03259542Completed33Est. Dec 2017
M&
Merck & Co.RAHWAY, NJ
1 program
elbasvir/grazoprevirN/ASmall Molecule1 trial
Active Trials
NCT03706222Completed400Est. Feb 2019

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Akebia TherapeuticsVadadustat
Akebia TherapeuticsVadadustat
Akebia Therapeuticsvadadustat
Akebia TherapeuticsVadadustat
Corcept TherapeuticsMifepristone 300 MG
Merck & Co.elbasvir/grazoprevir

Clinical Trials (6)

Total enrollment: 433 patients across 6 trials

NCT03789032Akebia TherapeuticsVadadustat

Study to Evaluate the Effect of Rabeprazole on the Pharmacokinetics of Vadadustat

Start: Oct 2018Est. completion: Nov 2018
Phase 1Completed
NCT03801759Akebia TherapeuticsVadadustat

Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide

Start: Jul 2018Est. completion: Sep 2018
Phase 1Completed
NCT03801746Akebia Therapeuticsvadadustat

Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin

Start: Jul 2018Est. completion: Aug 2018
Phase 1Completed
NCT03801733Akebia TherapeuticsVadadustat

Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin

Start: Jun 2018Est. completion: Nov 2018
Phase 1Completed
NCT03259542Corcept TherapeuticsMifepristone 300 MG

Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor

Start: Aug 2017Est. completion: Dec 201733 patients
Phase 1Completed
NCT03706222Merck & Co.elbasvir/grazoprevir

Drug-Drug Interactions of Grazoprevir/Elbasvir in Taiwan

Start: Oct 2018Est. completion: Feb 2019400 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

Small Molecule is the dominant modality (100% of programs)
3 companies competing in this space