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Diabetic Foot

13
Pipeline Programs
19
Companies
20
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
7
0
1
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Alliance Pharmaceuticals
1 program
1
CubicinPhase 41 trial
Active Trials
NCT01133600Terminated6Est. Aug 2012
Solventum
SolventumMN - St. Paul
1 program
1
V.A.C. ® SystemPhase 41 trial
Active Trials
NCT00224796Completed146Est. Oct 2005
Applied Biologics
Applied BiologicsAZ - Scottsdale
1 program
1
XWRAPPhase 41 trial
Active Trials
NCT07159282Recruiting60Est. Aug 2027
Oneness Biotech
Oneness BiotechTaiwan - Taipei City
2 programs
1
1
ON101 CreamPhase 31 trial
WH-1 ointmentPhase 11 trial
Active Trials
NCT02353273Completed12Est. Sep 2016
NCT01898923Completed236Est. May 2020
ViiV Healthcare
ViiV HealthcareNC - Durham
4 programs
3
Glucophage 1000mgPhase 2
Metformin 500mgPhase 2
Metformin GSK 850mgPhase 2
Study of Subjects With Diabetic Foot Ulcer (DFU)N/A
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
2 programs
1
1
External Chinese medicinePhase 21 trial
Huafu Shengji OintmentPhase 11 trial
Active Trials
NCT06487117Not Yet Recruiting60Est. Dec 2025
NCT03574935Unknown150Est. Oct 2019
Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY1193397Phase 21 trial
Active Trials
NCT03128320Completed23Est. Oct 2019
Energenesis Biomedical
Energenesis BiomedicalTaiwan - Taipei
1 program
1
ENERGI-F703Phase 21 trial
Active Trials
NCT02672436Completed141Est. Dec 2019
Tissue Repair
Tissue RepairAustralia - Sydney
1 program
1
GAM501Phase 21 trial
Active Trials
NCT00493051Completed124Est. Dec 2009
GSK
GSKLONDON, United Kingdom
4 programs
Study of Subjects With Diabetic Foot Ulcer (DFU)N/A1 trial
Glucophage 1000mgPHASE_21 trial
Metformin 500mgPHASE_21 trial
Metformin GSK 850mgPHASE_21 trial
Active Trials
NCT03153007Completed1Est. Dec 2017
NCT01710553Completed32Est. Jul 2012
NCT01710527Completed32Est. May 2012
+1 more trials
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Nerve BlockN/A1 trial
Active Trials
NCT06552910RecruitingEst. Dec 2024
Forte Biosciences
1 program
Sealed therapeutic shoeN/A1 trial
Active Trials
NCT04085926Terminated4Est. Feb 2022
PolyNovo
PolyNovoAustralia - Port Melbourne
1 program
SynPath Acellular Dermal Matrix plus Off-loading DeviceN/A1 trial
Active Trials
NCT05506215Terminated25Est. Feb 2024
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Application of autologous bone marrowPHASE_11 trial
Active Trials
NCT00292357Unknown40
Celularity
CelularityFLORHAM PARK, NJ
1 program
PDA-002PHASE_21 trial
Active Trials
NCT02460081Withdrawn0Est. Jan 2016
Organogenesis
OrganogenesisCANTON, MA
1 program
Bi-layered cell therapyPHASE_31 trial
Active Trials
NCT00512538Terminated82Est. Sep 2002

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Applied BiologicsXWRAP
Alliance PharmaceuticalsCubicin
SolventumV.A.C. ® System
Oneness BiotechON101 Cream
OrganogenesisBi-layered cell therapy
Integrated BiosciencesExternal Chinese medicine
BayerBAY1193397
Energenesis BiomedicalENERGI-F703
CelularityPDA-002
GSKMetformin GSK 850mg
GSKGlucophage 1000mg
GSKMetformin 500mg
Tissue RepairGAM501
Integrated BiosciencesHuafu Shengji Ointment
Oneness BiotechWH-1 ointment

Showing 15 of 19 trials with date data

Clinical Trials (20)

Total enrollment: 1,206 patients across 20 trials

A Multicenter, Prospective, Controlled Clinical Trial Evaluating the Efficacy of a Single Layer Placental-based Allograft and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers

Start: Aug 2025Est. completion: Aug 202760 patients
Phase 4Recruiting

Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimens

Start: Aug 2010Est. completion: Aug 20126 patients
Phase 4Terminated
NCT00224796SolventumV.A.C. ® System

Trial of Vacuum Assisted Closure® Therapy in Amputation Wounds of the Diabetic Foot

Start: May 2002Est. completion: Oct 2005146 patients
Phase 4Completed

Evaluate the Efficacy and Safety of ON101 Cream for the Treatment of Chronic Diabetic Foot Ulcers

Start: Nov 2012Est. completion: May 2020236 patients
Phase 3Completed
NCT00512538OrganogenesisBi-layered cell therapy

Apligraf Versus Standard Therapy in the Treatment of Diabetic Foot Ulcers

Start: Oct 2000Est. completion: Sep 200282 patients
Phase 3Terminated
NCT03574935Integrated BiosciencesExternal Chinese medicine

Clinical Evaluation and Generalized Application of "Qing-Hua-Bu" Three Dynamic Sequential Therapy of Diabetic Ulcer

Start: Jul 2018Est. completion: Oct 2019150 patients
Phase 2Unknown

The Effects of BAY1193397 on Skin Capillary Blood Flow and Transcutaneous Oxygen Pressure

Start: May 2017Est. completion: Oct 201923 patients
Phase 2Completed

ENERGI-F703 for Diabetic Foot Ulcers Phase II Study

Start: Mar 2017Est. completion: Dec 2019141 patients
Phase 2Completed

Hemodynamic Effects of Intramuscular PDA-002 in Subjects Who Have Diabetic Foot Ulcer With Peripheral Arterial Disease

Start: Jun 2015Est. completion: Jan 20160
Phase 2Withdrawn
NCT01710540GSKMetformin GSK 850mg

BE Study of Metformin GSK 850mg

Start: Aug 2012Est. completion: Aug 201232 patients
Phase 2Completed
NCT01710553GSKGlucophage 1000mg

BE STUDY OF METFORMIN GSK 1000mg

Start: Jul 2012Est. completion: Jul 201232 patients
Phase 2Completed
NCT01710527GSKMetformin 500mg

BE Study of Metformin GSK 500mg

Start: May 2012Est. completion: May 201232 patients
Phase 2Completed

Phase 2b Study of GAM501 in the Treatment of Diabetic Ulcers of the Lower Extremities

Start: Nov 2007Est. completion: Dec 2009124 patients
Phase 2Completed
NCT00292357Heidelberg PharmaApplication of autologous bone marrow

Local Application of Autologous Bone Marrow Cells for Treatment of Chronic Diabetic Ulcers

40 patients
Phase 1Unknown
NCT06487117Integrated BiosciencesHuafu Shengji Ointment

The Efficacy and Safety Assessment of Huafu Shengji Ointment in Patients With Diabetic Foot of Qi Deficiency and Blood Stasis Syndrome

Start: Sep 2024Est. completion: Dec 202560 patients
Phase 1Not Yet Recruiting

The Pharmacokinetic Study of WH-1 Ointment in Subjects With Chronic Diabetic Foot Ulcers

Start: Jul 2015Est. completion: Sep 201612 patients
Phase 1Completed

Analyzing Anesthetic Techniques in Diabetic Foot Amputation

Start: Jul 2024Est. completion: Dec 2024
N/ARecruiting
NCT05506215PolyNovoSynPath Acellular Dermal Matrix plus Off-loading Device

Randomized Clinical Study Comparing SynPath to Standard of Care in Treatment of Chronic Diabetic Foot Ulcers

Start: Jul 2022Est. completion: Feb 202425 patients
N/ATerminated
NCT04085926Forte BiosciencesSealed therapeutic shoe

Sealed Therapeutic Shoe as Treatment of Diabetic Foot Ulcers

Start: Jan 2020Est. completion: Feb 20224 patients
N/ATerminated
NCT03153007GSKStudy of Subjects With Diabetic Foot Ulcer (DFU)

Study of Subjects With Diabetic Foot Ulcer (DFU)

Start: Aug 2017Est. completion: Dec 20171 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 1,206 patients
19 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.