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Chest Pain

2
Pipeline Programs
11
Companies
11
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 12 programs with unclassified modality

Competitive Landscape

10 companies ranked by most advanced pipeline stage

AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
EsomeprazolePhase 3Small Molecule1 trial
Active Trials
NCT00251901Completed600Est. Jul 2005
Innovation Pharmaceuticals
1 program
1
Autologous peripheral blood CD34 positive cell therapyPhase 1/21 trial
Active Trials
NCT00221182Terminated1Est. Sep 2009
GE HealthCare
2 programs
CT ThoraxN/A1 trial
Diagnostic Accuracy of Multislice CT Angiography for Acute Chest PainN/A1 trial
Active Trials
NCT05058300Unknown3,000Est. Oct 2024
NCT00855231Completed102Est. Sep 2009
Roche
RocheSTAVANGER NORWAY, Norway
2 programs
IN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE)N/A1 trial
The Pre-hospital Evaluation of Sensitive Troponin (PRESTO) StudyN/A
Active Trials
NCT04756362Completed5,497Est. Jul 2022
Abbott
AbbottABBOTT PARK, IL
2 programs
The Pre-hospital Evaluation of Sensitive Troponin (PRESTO) StudyN/A1 trial
blood takingN/A1 trial
Active Trials
NCT03561051Unknown700Est. Jan 2025
NCT02789904Completed1,200Est. Nov 2017
Astellas
AstellasChina - Shenyang
1 program
AspirinN/A1 trial
Active Trials
NCT00743197Terminated3Est. May 2010
Shield Therapeutics
Shield TherapeuticsMA - Wellesley
1 program
Risk Markers in the Acute Coronary SyndromesN/A1 trial
Active Trials
NCT00521976Completed871Est. Dec 2005
Nihon Kohden
Nihon KohdenNEW YORK, NY
1 program
Two consecutive 15-lead ECGsN/A1 trial
Active Trials
NCT03426436Completed314Est. Aug 2019
Siemens Healthineers
Siemens HealthineersGermany - Forchheim
1 program
modified HEART scoreN/A1 trial
Active Trials
NCT04904107Unknown852Est. Jun 2024
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Autologous peripheral blood CD34 positive cell therapyPHASE_1_2

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AstraZenecaEsomeprazole
Innovation PharmaceuticalsAutologous peripheral blood CD34 positive cell therapy
Siemens Healthineersmodified HEART score
RocheIN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE)
AbbottThe Pre-hospital Evaluation of Sensitive Troponin (PRESTO) Study
Nihon KohdenTwo consecutive 15-lead ECGs
GE HealthCareCT Thorax
Abbottblood taking
AstellasAspirin
GE HealthCareDiagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain
Shield TherapeuticsRisk Markers in the Acute Coronary Syndromes

Clinical Trials (11)

Total enrollment: 13,140 patients across 11 trials

NCT00251901AstraZenecaEsomeprazole

Chest Pain Pilot Study

Start: May 2004Est. completion: Jul 2005600 patients
Phase 3Completed
NCT00221182Innovation PharmaceuticalsAutologous peripheral blood CD34 positive cell therapy

Stem Cell Study for Patients With Heart Disease

Start: Sep 2005Est. completion: Sep 20091 patients
Phase 1/2Terminated
NCT04904107Siemens Healthineersmodified HEART score

Improving the Accuracy of Referrals of Patients With Chest Pain

Start: Jul 2021Est. completion: Jun 2024852 patients
N/AUnknown
NCT04756362RocheIN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE)

IN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE)

Start: Jul 2020Est. completion: Jul 20225,497 patients
N/ACompleted
NCT03561051AbbottThe Pre-hospital Evaluation of Sensitive Troponin (PRESTO) Study

The Pre-hospital Evaluation of Sensitive Troponin (PRESTO) Study

Start: Oct 2018Est. completion: Jan 2025700 patients
N/AUnknown
NCT03426436Nihon KohdenTwo consecutive 15-lead ECGs

Evaluation of Synthesized 18-Lead ECG in the Emergency Department

Start: Feb 2018Est. completion: Aug 2019314 patients
N/ACompleted
NCT05058300GE HealthCareCT Thorax

Prospective Registry for Patients With Chest Pain in Emergency Department

Start: Sep 2017Est. completion: Oct 20243,000 patients
N/AUnknown
NCT02789904Abbottblood taking

Evaluation of hsTnI in the Management of Patients With Chest Pain in the Emergency Department

Start: Oct 2015Est. completion: Nov 20171,200 patients
N/ACompleted
NCT00743197AstellasAspirin

Women With Chest Pain and Normal Coronary Arteries Study

Start: May 2008Est. completion: May 20103 patients
N/ATerminated
NCT00855231GE HealthCareDiagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain

Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain

Start: Jul 2006Est. completion: Sep 2009102 patients
N/ACompleted
NCT00521976Shield TherapeuticsRisk Markers in the Acute Coronary Syndromes

Risk Markers in the Acute Coronary Syndromes

Start: Nov 2002Est. completion: Dec 2005871 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.