Chagas Disease
Pipeline by Development Stage
Drug Modality Breakdown
On Market (1)
Approved therapies currently available
Competitive Landscape
11 companies ranked by most advanced pipeline stage
Trial Timeline
Clinical trial activity over time
Showing 15 of 41 trials with date data
Clinical Trials (42)
Total enrollment: 38,886 patients across 42 trials
Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC
Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants
Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients
Dosing Obese With Noxafil® Under a Trial (DONUT)
Posaconazole as Salvage Therapy for Aspergillus Pulmonary Infection.
Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease
A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)
Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)
A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi
Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101)
Safety and Efficacy Study of Posaconazole vs. Fluconazole for Prevention of Invasive Fungal Infection (P05387 AM1)(COMPLETED)
Posaconazole Treatment of Invasive Fungal Infection (IFI) (P05551)
POS vs FLU for First Line Treatment of Coccidioidomycosis (Study P04558Am1)(COMPLETED)
Prophylaxis Trial of Posaconazole Versus Standard Azole Therapy for Neutropenic Patients (Study P01899)
Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095)
Prophylaxis Trial in High Risk Allogenic Stem Cell Transplant Recipients With Graft vs. Host Disease
Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041)
Universal Prophylaxis Versus Pre-emptive Therapy With Posaconazole Post-Lung Transplant
Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients
A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267)
Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma
A Study to Examine the Efficacy and Safety of Posaconazole When Introduced Early in the Treatment of Refractory Fungal Infections (P05090 AM2)
PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)
Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study
Study to Assess Bioequivalence of a New Nifurtimox Oral Tablet Formulation
Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mg
Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients
Pharmacokinetics and Safety of Oral Posaconazole (MK-5592)Tablets in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-117)
Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients
Pharmacokinetics and Safety of Posaconazole Tablet in Participants at High Risk for Invasive Fungal Infections (MK-5592-065/P05615)
A Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children (P03579)
Single Patient Treatment of Posaconazole in Invasive Fungal Infections (Study P05113)
An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health
Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients
Study on Benefits of Therapy With Nifurtimox in Chagas Disease, a Parasitic Illness Mostly Transmitted to Humans by a Bug, Using Information From Patient Medical Records in Argentina
Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project)
Abbott ESA Chagas Assay Post-Market Study
Safety and Efficacy of Posaconazole Oral Suspension in Usual Practice in Korea (P08547)
Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients
Congenital Transmission of Lineages I and II of Trypanosoma Cruzi
Evaluation of Treatment and Prophylaxis of Invasive Fungal Infections in Immuncompromised Patients in Austria (Study P05532)(WITHDRAWN)
Post-marketing Surveillance Study of Invasive Mycosis With Posaconazole (Study P04641)
Phase Legend
Key Insights
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