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Chagas Disease

6
Pipeline Programs
11
Companies
42
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
3
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
5100%
+ 7 programs with unclassified modality

On Market (1)

Approved therapies currently available

Bayer
LAMPITApproved
nifurtimox
Bayer
oral2020

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
2 programs
1
1
Sacubitril/valsartanPhase 4Small Molecule
LXE408Phase 2
Bayer
BayerLEVERKUSEN, Germany
1 program
1
LAMPIT(nifurtimox)N/A5 trials
Active Trials
NCT05477953Not Yet Recruiting50Est. Jan 2032
NCT03334838Completed36Est. Jan 2020
NCT03784391Completed3,000Est. Apr 2020
+2 more trials
Medtronic
MedtronicNJ - Phillipsburg
1 program
1
Implantable Cardiac MonitorPhase 4
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
PosaconazolePhase 2Small Molecule
MSD
MSDIreland - Ballydine
1 program
1
PosaconazolePhase 2Small Molecule
Labcorp
LabcorpBURLINGTON, NC
1 program
Congenital Transmission of Lineages I and II of Trypanosoma CruziN/A1 trial
Active Trials
NCT01787968Completed28,348Est. Dec 2013
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project)N/A1 trial
Active Trials
NCT02646943Completed1,959Est. Aug 2014
Abbott
AbbottABBOTT PARK, IL
1 program
Testing Donor Specimens with ESA ChagasN/A1 trial
Active Trials
NCT01662362Completed63Est. Dec 2012
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
PosaconazolePHASE_2Small Molecule5 trials
Active Trials
NCT00686621Approved For Marketing
NCT05065658Completed249Est. Aug 2023
NCT03717623Recruiting100Est. Dec 2025
+2 more trials
Rhythm Pharmaceuticals
1 program
Implantable Cardiac MonitorPHASE_41 trial
Active Trials
NCT01539161Terminated12Est. Apr 2015
Novartis
NovartisBASEL, Switzerland
1 program
Sacubitril/valsartanPHASE_4Small Molecule1 trial
Active Trials
NCT04023227Completed922Est. Mar 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
NovartisSacubitril/valsartan
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Rhythm PharmaceuticalsImplantable Cardiac Monitor
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Bayernifurtimox
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole
Merck & Co.Posaconazole

Showing 15 of 41 trials with date data

Clinical Trials (42)

Total enrollment: 38,886 patients across 42 trials

NCT04023227NovartisSacubitril/valsartan

Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC

Start: Dec 2019Est. completion: Mar 2025922 patients
Phase 4Completed

Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants

Start: Aug 2019Est. completion: Dec 2025100 patients
Phase 4Recruiting

Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients

Start: Dec 2017Est. completion: Mar 202188 patients
Phase 4Completed

Dosing Obese With Noxafil® Under a Trial (DONUT)

Start: Nov 2017Est. completion: Sep 201824 patients
Phase 4Completed

Posaconazole as Salvage Therapy for Aspergillus Pulmonary Infection.

Start: Dec 20130
Phase 4Withdrawn
NCT01539161Rhythm PharmaceuticalsImplantable Cardiac Monitor

Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease

Start: Jul 2013Est. completion: Apr 201512 patients
Phase 4Terminated

A Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients (MK-5592-105)

Start: Jan 2013Est. completion: Jan 201426 patients
Phase 4Terminated

Oral Posaconazole in High Risk Patients With Gastrointestinal Dysfunction (Study P05115)

Start: Dec 2007Est. completion: Apr 200975 patients
Phase 4Completed

A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi

Start: Jan 2016Est. completion: Aug 2021330 patients
Phase 3Completed

Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101)

Start: Jul 2014Est. completion: Jan 2018116 patients
Phase 3Completed

Safety and Efficacy Study of Posaconazole vs. Fluconazole for Prevention of Invasive Fungal Infection (P05387 AM1)(COMPLETED)

Start: Nov 2008Est. completion: May 2010252 patients
Phase 3Completed

Posaconazole Treatment of Invasive Fungal Infection (IFI) (P05551)

Start: Nov 2008Est. completion: Mar 201063 patients
Phase 3Completed

POS vs FLU for First Line Treatment of Coccidioidomycosis (Study P04558Am1)(COMPLETED)

Start: May 2007Est. completion: May 200916 patients
Phase 3Completed

Prophylaxis Trial of Posaconazole Versus Standard Azole Therapy for Neutropenic Patients (Study P01899)

Start: Jul 2002Est. completion: Apr 2005602 patients
Phase 3Completed

Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095)

Start: Apr 2001Est. completion: Mar 2007
Phase 3Completed

Prophylaxis Trial in High Risk Allogenic Stem Cell Transplant Recipients With Graft vs. Host Disease

Start: Jan 1999Est. completion: Feb 2003600 patients
Phase 3Completed

Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041)

Start: Dec 1998Est. completion: Mar 2002336 patients
Phase 3Completed

Universal Prophylaxis Versus Pre-emptive Therapy With Posaconazole Post-Lung Transplant

Start: Jul 2018Est. completion: Sep 2020140 patients
Phase 2Unknown

Posaconazole Prophylaxis During ATG Treatment for hMDS/AA Patients

Start: Apr 2018Est. completion: Jul 202320 patients
Phase 2Completed

A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267)

Start: Jul 2011Est. completion: Jan 2015120 patients
Phase 2Completed

Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma

Start: Jan 2008Est. completion: Oct 2022112 patients
Phase 2Completed

A Study to Examine the Efficacy and Safety of Posaconazole When Introduced Early in the Treatment of Refractory Fungal Infections (P05090 AM2)

Start: Dec 2007Est. completion: Nov 201240 patients
Phase 2Completed

PK/PD Study of Posaconazole for Empiric Treatment of Invasive Fungal Infections in Neutropenic Patients or Treatment of Refractory Invasive Fungal Infections (Study P01893)

Start: Jan 2001Est. completion: Mar 200298 patients
Phase 2Completed

Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients - Dietary Habits Study

Start: Jun 2019Est. completion: Jan 202036 patients
Phase 1Completed

Study to Assess Bioequivalence of a New Nifurtimox Oral Tablet Formulation

Start: Dec 2018Est. completion: Jun 201924 patients
Phase 1Completed

Study Will Evaluate the Relative Bioavailability, Safety, and Tolerability of Single Doses of Nifurtimox 30 mg Tablets Exhibiting Different in Vitro Dissolution Characteristics, and to Evaluate the Relative Bioavailability of Nifurtimox 30 mg and 120 mg

Start: Jun 2018Est. completion: Dec 201848 patients
Phase 1Completed

Study to Assess the Food Effect on the Pharmacokinetics of Nifurtimox Tablets in Chronic Chagas' Patients

Start: Dec 2015Est. completion: Aug 201636 patients
Phase 1Completed

Pharmacokinetics and Safety of Oral Posaconazole (MK-5592)Tablets in Chinese Participants at High Risk for Invasive Fungal Infections (MK-5592-117)

Start: May 2015Est. completion: May 201665 patients
Phase 1Completed

Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients

Start: Nov 2013Est. completion: Sep 201437 patients
Phase 1Completed

Pharmacokinetics and Safety of Posaconazole Tablet in Participants at High Risk for Invasive Fungal Infections (MK-5592-065/P05615)

Start: Jun 2009Est. completion: Feb 2012230 patients
Phase 1Completed

A Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children (P03579)

Start: Apr 2008Est. completion: Apr 2015142 patients
Phase 1Terminated

Single Patient Treatment of Posaconazole in Invasive Fungal Infections (Study P05113)

N/AApproved For Marketing

An Observational Pregnancy Safety Study in Women Who Were Exposed to the Drug Nifurtimox During Pregnancy to Learn About the Risk of Pregnancy Complications and About the Mother's and Baby's Health

Start: Jun 2026Est. completion: Jan 203250 patients
N/ANot Yet Recruiting

Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients

Start: Mar 2020Est. completion: Aug 2023249 patients
N/ACompleted

Study on Benefits of Therapy With Nifurtimox in Chagas Disease, a Parasitic Illness Mostly Transmitted to Humans by a Bug, Using Information From Patient Medical Records in Argentina

Start: Dec 2018Est. completion: Apr 20203,000 patients
N/ACompleted
NCT02646943Allergy TherapeuticsLongitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project)

Longitudinal Study of Patients With Chronic Chagas Cardiomyopathy in Brazil (SaMi_Trop Project)

Start: Jul 2013Est. completion: Aug 20141,959 patients
N/ACompleted
NCT01662362AbbottTesting Donor Specimens with ESA Chagas

Abbott ESA Chagas Assay Post-Market Study

Start: Jul 2012Est. completion: Dec 201263 patients
N/ACompleted

Safety and Efficacy of Posaconazole Oral Suspension in Usual Practice in Korea (P08547)

Start: Feb 2012Est. completion: Nov 2013273 patients
N/ACompleted

Pharmacokinetic Analysis of Posaconazole in Lung Transplant Recipients

Start: Oct 2011Est. completion: Dec 201420 patients
N/ACompleted
NCT01787968LabcorpCongenital Transmission of Lineages I and II of Trypanosoma Cruzi

Congenital Transmission of Lineages I and II of Trypanosoma Cruzi

Start: Apr 2011Est. completion: Dec 201328,348 patients
N/ACompleted

Evaluation of Treatment and Prophylaxis of Invasive Fungal Infections in Immuncompromised Patients in Austria (Study P05532)(WITHDRAWN)

Start: Jul 2008Est. completion: Jun 20110
N/AWithdrawn

Post-marketing Surveillance Study of Invasive Mycosis With Posaconazole (Study P04641)

Start: Jan 2006Est. completion: Jul 2008214 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 actively recruiting trials targeting 38,886 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.