Cerebral Palsy

Pipeline Programs

Companies

Clinical Trials

7 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

31 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Angeles Therapeutics

6 programs

Ropivacaine injectionPhase 41 trial

High frequency, low magnitude vibrationPhase 21 trial

Augment Reality ExergamesN/A1 trial

Cionic Neural Sleeve NS-100N/A1 trial

+1 more programs

Active Trials

NCT06096272Recruiting30Est. Sep 2025

NCT05660096Withdrawn0Est. Dec 2026

NCT04561232Completed60Est. Aug 2025

+3 more trials

Human BioSciencesWV - Martinsburg

29 programs

magnesium sulfatePhase 31 trial

Botulinum toxin type APhase 21 trial

Pediatric Constraint-Induced Movement therapyPhase 21 trial

Robotic Ankle Assist DevicePhase 11 trial

Sprint-Intensity Interval Training with TelecoachingPhase 11 trial

+24 more programs

Active Trials

NCT04997109Recruiting267Est. Feb 2027

NCT03635775Completed20Est. Feb 2020

NCT01217242Completed128Est. Dec 2011

+25 more trials

MedtronicNJ - Phillipsburg

2 programs

baclofen, intrathecalPhase 31 trial

Intrathecal Baclofen PumpN/A1 trial

Active Trials

NCT05817409Not Yet Recruiting75Est. Dec 2027

NCT00367068Completed18Est. May 2007

ShionogiJapan - Osaka

1 program

Oral Glycopyrrolate LiquidPhase 31 trial

Active Trials

NCT00491894Completed137Est. Jun 2008

SpineXCA - Northridge

2 programs

SCiPPhase 21 trial

SCiPPhase 11 trial

Active Trials

NCT04882592Unknown50Est. Dec 2024

NCT05720208Unknown60Est. Sep 2025

Alliance PharmaceuticalsUK - Wiltshire

2 programs

Matched sibling donor cord blood cell infusionPhase 11 trial

Natural History of Cerebral Palsy Prospective StudyN/A1 trial

Active Trials

NCT05576948Recruiting100Est. Sep 2027

NCT03087110Completed12Est. Dec 2020

Spine BioPharmaNY - New York

2 programs

Autologous bone marrow mononuclear cell transplantationPhase 11 trial

Intrathecal autologous bone marrow mononuclear cell transplantationPhase 11 trial

Active Trials

NCT01978821Withdrawn0Est. Aug 2013

NCT02241395Withdrawn0Est. Dec 2018

BiocorpFrance - Issoire

1 program

ASTROSTEMPhase 11 trial

Active Trials

NCT03979898Completed1Est. May 2019

R-BioTX - Houston

1 program

ASTROSTEMPhase 1

BiomotumOR - Portland

1 program

Robotic Ankle Assist DevicePhase 1

StemCyteCA - Baldwin Park

1 program

hUCBPhase 11 trial

Active Trials

NCT06377982Not Yet Recruiting12Est. Dec 2028

Colorado TherapeuticsCO - Louisville

5 programs

Cerebral Palsy Adult Transition Longitudinal StudyN/A1 trial

Long-Term Outcomes of Hip Interventions for Children With Cerebral PalsyN/A1 trial

Outcomes of the Evans Calcaneal Lengthening Based on Bone Grafting MaterialN/A1 trial

The intervention group: Neurophysiologically Based Occupational Therapy InterventionN/A1 trial

oral analgesicN/A1 trial

Active Trials

NCT02137005Active Not Recruiting72Est. Dec 2026

NCT04792606Recruiting1,000Est. Mar 2028

NCT02075853Completed20Est. Nov 2018

+2 more trials

IpsenChina - Tianjin

3 programs

Botulinum toxin type APHASE_21 trial

Botulinum toxin type APHASE_31 trial

Active Trials

NCT00455637Terminated6Est. Mar 2008

NCT01251380Completed216Est. Jan 2015

NCT01249417Completed241Est. Jun 2014

Temple TherapeuticsNetherlands - Geleen

2 programs

Balance and Posture in Adults With Cerebral PalsyN/A1 trial

Sensory Integration TestingN/A1 trial

Active Trials

NCT01585571Completed80Est. Feb 2020

NCT02456376Unknown20Est. Dec 2016

Oregon TherapeuticsFrance - Paris

2 programs

Permobil Explorer MiniN/A

Targeted TrainingN/A1 trial

Active Trials

NCT02097836Completed11Est. Jan 2010

Nielsen BioSciencesCA - San Diego

1 program

Cerebral Palsy & Predictors of Physical ActivityN/A1 trial

Active Trials

NCT04614207Completed123Est. Jan 2022

Ability PharmaSpain - Cerdanyola

1 program

Empowering youth towards employmentN/A1 trial

Active Trials

NCT02522507Completed44Est. Jul 2020

OttobockNEW YORK, NY

1 program

Exopulse Mollii SuitN/A1 trial

Active Trials

NCT05885139Unknown34Est. Jun 2024

Martin PharmaceuticalsNY - New York

1 program

High Intensity Interval TrainingN/A1 trial

Active Trials

NCT02319122Completed22Est. Jul 2017

Hamilton medicalSwitzerland - Bonaduz

1 program

Implementation groupN/A1 trial

Active Trials

NCT06537622Not Yet Recruiting2,000Est. Nov 2028

Alder TherapeuticsSweden - Solna

1 program

Long-Term Outcomes of Hip Interventions for Children With Cerebral PalsyN/A

Cosmo PharmaceuticalsIreland - Dublin

1 program

Powered Exoskeleton Gait TrainingN/A1 trial

Active Trials

NCT05759182Completed10Est. Nov 2024

Walden BiosciencesMA - Cambridge

1 program

The intervention group: Neurophysiologically Based Occupational Therapy InterventionN/A

Chong Kun Dang PharmaceuticalKorea - Seodaemun

1 program

Umbilical Cord Blood therapyN/A1 trial

Active Trials

NCT01991145Completed92Est. Jun 2017

IlluminaCA - Hayward

1 program

Whole-genome sequencingN/A1 trial

Active Trials

NCT05858268Active Not Recruiting66Est. Jan 2026

Sound PharmaceuticalsWA - Seattle

1 program

home-based treadmill trainingN/A1 trial

Active Trials

NCT02424526Completed19Est. Sep 2018

Libra TherapeuticsCA - San Diego

1 program

reproducibility of upper extremity strength measurementsN/A1 trial

Active Trials

NCT02146989Completed370Est. Mar 2018

Verona PharmaUK - London

1 program

Device: Electromechanical gait trainerPHASE_11 trial

Active Trials

NCT01564433Completed20Est. Jan 2012

Mission TherapeuticsUK - Cambridge

1 program

umbilical cord bloodPHASE_2

Connect BiopharmaSAN DIEGO, CA

1 program

umbilical cord bloodPHASE_21 trial

Active Trials

NCT01988584Completed20Est. Feb 2018

+1 more companies

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

Angeles TherapeuticsRopivacaine injection

Jazz PharmaceuticalsSativex

IpsenBotulinum toxin type A

ShionogiOral Glycopyrrolate Liquid

Medtronicbaclofen, intrathecal

Human BioSciencesmagnesium sulfate

SpineXSCiP

Connect Biopharmaumbilical cord blood

IpsenBotulinum toxin type A

Angeles TherapeuticsHigh frequency, low magnitude vibration

Human BioSciencesPediatric Constraint-Induced Movement therapy

Human BioSciencesBotulinum toxin type A

StemCytehUCB

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 7,979 patients across 50 trials

NCT06189781 Angeles TherapeuticsRopivacaine injection

Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy

Start: Dec 2023Est. completion: Jun 202790 patients

Phase 4Recruiting

NCT04074265 Angeles TherapeuticsRopivacaine injection

Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy

Start: Dec 2019Est. completion: Apr 202334 patients

Phase 4Completed

NCT01898520 Jazz PharmaceuticalsSativex

A Safety, Efficacy and Tolerability Study of Sativex for the Treatment of Spasticity in Children Aged 8 to 18 Years

Start: Dec 2013Est. completion: Mar 201772 patients

Phase 3Completed

NCT01251380 IpsenBotulinum toxin type A

Dysport® Pediatric Lower Limb Spasticity Follow-on Study

Start: Oct 2011Est. completion: Jan 2015216 patients

Phase 3Completed

NCT01249417 IpsenBotulinum toxin type A

Dysport® Pediatric Lower Limb Spasticity Study

Start: Jul 2011Est. completion: Jun 2014241 patients

Phase 3Completed

NCT00491894 ShionogiOral Glycopyrrolate Liquid

Safety and Efficacy Study of Oral Glycopyrrolate Liquid for the Treatment of Pathologic (Chronic Moderate to Severe) Drooling in Pediatric Patients 3 to 18 Years of Age With Cerebral Palsy or Other Neurologic Conditions

Start: Mar 2007Est. completion: Jun 2008137 patients

Phase 3Completed

NCT00367068 Medtronicbaclofen, intrathecal

Dutch National ITB Study in Children With Cerebral Palsy

Start: Jan 2002Est. completion: May 200718 patients

Phase 3Completed

NCT00014989 Human BioSciencesmagnesium sulfate

Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)

Start: Dec 1997Est. completion: Jun 20072,136 patients

Phase 3Completed

NCT05720208 SpineXSCiP

Spinal Cord Innovation in Pediatrics (SCiP) to Treat SensoriMotor Function in Children Cerebral Palsy: Protocol for a Randomized Controlled Trial

Start: Sep 2023Est. completion: Sep 202560 patients

Phase 2Unknown

NCT01988584 Connect Biopharmaumbilical cord blood

Safety and Effectiveness of Banked Cord Blood or Bone Marrow Stem Cells in Children With Cerebral Palsy (CP).

Start: Nov 2013Est. completion: Feb 201820 patients

Phase 2Completed

NCT00455637 IpsenBotulinum toxin type A

Which is the Best Dose of Dysport in Helping With Hip Pain for Children With Cerebral Palsy?

Start: Mar 2007Est. completion: Mar 20086 patients

Phase 2Terminated

NCT00295295 Angeles TherapeuticsHigh frequency, low magnitude vibration

Vibration Intervention to Improve Bone and Muscle in Children With Cerebral Palsy

Start: Sep 2004Est. completion: Sep 200734 patients

Phase 2Completed

NCT00061139 Human BioSciencesPediatric Constraint-Induced Movement therapy

Constraint-Based Therapy to Improve Motor Function in Children With Cerebral Palsy

Start: Sep 2002Est. completion: Sep 200652 patients

Phase 2Unknown

NCT00060957 Human BioSciencesBotulinum toxin type A

Botulinum Toxin (BOTOX) for Cerebral Palsy

Start: Jul 199740 patients

Phase 2Completed

NCT06377982 StemCytehUCB

Human Umbilical Cord Blood Infusion in Patients with Cerebral Palsy

Start: Sep 2025Est. completion: Dec 202812 patients

Phase 1Not Yet Recruiting

NCT06455930 Human BioSciencesStand-on ride-on power mobility device

Stand-on Ride-on Power Mobility Devices for Children With Cerebral Palsy

Start: Jun 2024Est. completion: Jul 202610 patients

Phase 1Recruiting

NCT05619211 Human BioSciencesSprint-Intensity Interval Training with Telecoaching

Piloting Movement-to-Music With Arm-based Sprint-Intensity Interval Training Among Children With Physical Disabilities

Start: Sep 2023Est. completion: Dec 202542 patients

Phase 1Completed

NCT05336227 Human BioSciencesVirtual Reality Exergaming

Telehealth Virtual Reality Gaming on Cardiometabolic Health Among Youth With Cerebral Palsy

Start: Jun 2022Est. completion: Feb 202532 patients

Phase 1Completed

NCT04882592 SpineXSCiP

Noninvasive Spinal Neuromodulation Enables Locomotor Recovery in Individuals With Cerebral Palsy

Start: May 2021Est. completion: Dec 202450 patients

Phase 1Unknown

NCT04516343 Human BioSciencesRobotic Ankle Assist Device

Development of a Robotic Ankle Assist Device

Start: Nov 2020Est. completion: Aug 202431 patients

Phase 1Completed

NCT04119063 Human BioSciencespowered orthosis

Evaluating Wearable Robotic Assistance on Gait

Start: Sep 2019Est. completion: Nov 20226 patients

Phase 1Completed

NCT03979898 BiocorpASTROSTEM

Safety and Effectiveness of Autologous Adipose Tissue Derived Mesenchymal Stem Cell Implantation in Patients With CP

Start: Jun 2017Est. completion: May 20191 patients

Phase 1Completed

NCT03087110 Alliance PharmaceuticalsMatched sibling donor cord blood cell infusion

Stem Cells in Umbilical Blood Infusion for CP

Start: Mar 2016Est. completion: Dec 202012 patients

Phase 1Completed

NCT02241395 Spine BioPharmaIntrathecal autologous bone marrow mononuclear cell transplantation

Cell Therapy as Treatment for Cerebral Palsy

Start: Aug 2013Est. completion: Dec 20180

Phase 1Withdrawn

NCT01564433 Verona PharmaDevice: Electromechanical gait trainer

Effects of Electromechanical Gait Trainer in Patients With Cerebral Palsy

Start: Nov 2011Est. completion: Jan 201220 patients

Phase 1Completed

NCT01978821 Spine BioPharmaAutologous bone marrow mononuclear cell transplantation

Stem Cell Therapy for Cerebral Palsy

Start: Aug 2010Est. completion: Aug 20130

Phase 1Withdrawn

NCT06537622 Hamilton medicalImplementation group

Best Practices Fo Early Diagnosis of Cerebral Palsy

Start: Feb 2025Est. completion: Nov 20282,000 patients

N/ANot Yet Recruiting

NCT05759182 Cosmo PharmaceuticalsPowered Exoskeleton Gait Training

The Effects of Exoskeletal Robot-Assisted Gait Training on Children With Cerebral Palsy: A Pilot Study

Start: Sep 2024Est. completion: Nov 202410 patients

N/ACompleted

NCT06096272 Angeles TherapeuticsAugment Reality Exergames

Using Augmented Reality to Promote Physical Activity in Children With Cerebral Palsy

Start: Jun 2024Est. completion: Sep 202530 patients

N/ARecruiting

NCT05660096 Angeles TherapeuticsCionic Neural Sleeve NS-100

Pediatric Neural Sleeve Validation

Start: Jan 2024Est. completion: Dec 20260

N/AWithdrawn

NCT04303078 Human BioSciencesVarying levels of harness support during walking

Quantifying Energetic Demands of Walking for People With Cerebral Palsy

Start: Aug 2023Est. completion: Jun 202534 patients

N/ACompleted

NCT05817409 MedtronicIntrathecal Baclofen Pump

Predictive Factors for Succes of ITB in CP

Start: Jun 2023Est. completion: Dec 202775 patients

N/ANot Yet Recruiting

NCT05885139 OttobockExopulse Mollii Suit

Exopulse Mollii Suit, Motor Functions & CP Children With Cerebral Palsy

Start: Apr 2023Est. completion: Jun 202434 patients

N/AUnknown

NCT05858268 IlluminaWhole-genome sequencing

NeuralNET Cerebral Palsy Pilot Study

Start: Apr 2023Est. completion: Jan 202666 patients

N/AActive Not Recruiting

NCT05764681 Human BioSciencesChronic Postsurgical Pain

Chronic Postsurgical Pain

Start: Mar 2023Est. completion: Jan 2029500 patients

N/ARecruiting

NCT05576948 Alliance PharmaceuticalsNatural History of Cerebral Palsy Prospective Study

Natural History of Cerebral Palsy Prospective Study

Start: Sep 2022Est. completion: Sep 2027100 patients

N/ARecruiting

NCT04997109 Human BioSciencesAPPLES-tele

Telemedicine in Early Childhood Constraint Therapy in Cerebral Palsy

Start: Feb 2022Est. completion: Feb 2027267 patients

N/ARecruiting

NCT05130528 Human BioSciencesSensorimotor Intervention

Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy

Start: Feb 2022Est. completion: Apr 202412 patients

N/ACompleted

NCT04612049 Human BioSciencesImmersive virtual reality visuo-motor skill assessment

Immersive Virtual Reality for Visuo-motor Integration Skill Assessment

Start: May 2021Est. completion: Dec 202112 patients

N/ATerminated

NCT04684576 Human BioSciencesPermobil Explorer Mini

Early Powered Mobility for Toddlers With Cerebral Palsy Using the Permobil® Explorer Mini and a Modified Ride-On Car

Start: Apr 2021Est. completion: May 202224 patients

N/ACompleted

NCT04561232 Angeles TherapeuticsProne and Upright Locomotor Training

Locomotor Learning in Infants at High Risk for Cerebral Palsy

Start: Dec 2020Est. completion: Aug 202560 patients

N/ACompleted

NCT05465239 Human BioSciencesSurePace Powered Walker User

Intelligent and Adaptive Control Applied to Powered Walkers

Start: Dec 2020Est. completion: Sep 202348 patients

N/ACompleted

NCT04614207 Nielsen BioSciencesCerebral Palsy & Predictors of Physical Activity

Cerebral Palsy & Predictors of Physical Activity

Start: Nov 2020Est. completion: Jan 2022123 patients

N/ACompleted

NCT04792606 Colorado TherapeuticsLong-Term Outcomes of Hip Interventions for Children With Cerebral Palsy

Long-Term Outcomes of Hip Interventions for Children With Cerebral Palsy

Start: Oct 2019Est. completion: Mar 20281,000 patients

N/ARecruiting

NCT04330859 Human BioSciencesNeoRehab Bundle

NEO Rehab Program for Premature Infants at Risk for Cerebral Palsy

Start: May 2019Est. completion: Aug 202170 patients

N/ACompleted

NCT03625570 Human BioSciencesPower training combined with interval treadmill training

Power Training Combined With Interval Treadmill Training

Start: Apr 2019Est. completion: Nov 202344 patients

N/ACompleted

NCT03635775 Human BioSciencesActive tDCS

Single-session tDCS in Cerebral Palsy

Start: May 2018Est. completion: Feb 202020 patients

N/ACompleted

NCT02925455 Human BioSciencesContralaterally-controlled functional electrical stimulation

Contralaterally Controlled FES for Hand Opening in Hemiplegic Cerebral Palsy

Start: Oct 2016Est. completion: Apr 202015 patients

N/ACompleted

NCT02522507 Ability PharmaEmpowering youth towards employment

A Peer E-mentoring Intervention to Improve Employment

Start: Jan 2016Est. completion: Jul 202044 patients

N/ACompleted

NCT02424526 Sound Pharmaceuticalshome-based treadmill training

Intensive Home-based Treadmill Training and Walking Attainment in Young Children With Cerebral Palsy

Start: Jul 2015Est. completion: Sep 201819 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals

7 actively recruiting trials targeting 7,979 patients

30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.