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Cardiac Surgery

4
Pipeline Programs
14
Companies
14
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
2
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
1
Acute normovolemic hemodilutionPhase 31 trial
Active Trials
NCT05049590Completed63Est. Jun 2023
Stryker
StrykerCA - San Jose
2 programs
1
1
RopivacainePhase 2/3
Rapr Rounds Hyper/Hypothermia WrapsPhase 21 trial
Active Trials
NCT03947671Withdrawn0Est. Oct 2026
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
1
RopivacainePhase 2/31 trial
Active Trials
NCT00586976Terminated125Est. Jun 2008
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
2 programs
L-Alanyl/L-GlutaminePHASE_31 trial
HES 130/0.4PHASE_41 trial
Active Trials
NCT04019184Completed64Est. May 2020
NCT00860405Completed61Est. Dec 2010
Medtronic
MedtronicNJ - Phillipsburg
1 program
Activated clotting time versus blood-heparin concentrationN/A1 trial
Active Trials
NCT01462968Withdrawn0Est. Mar 2012
Shield Therapeutics
Shield TherapeuticsMA - Wellesley
1 program
Comfort CoachN/A1 trial
Active Trials
NCT04051021Completed160Est. Jan 2021
Innovation Pharmaceuticals
1 program
Self-swabbing of surgical woundN/A1 trial
Active Trials
NCT07200401Recruiting40Est. Feb 2026
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
Sternalock 360 sternal plating systemN/A1 trial
Active Trials
NCT03282578Completed50Est. Nov 2018
Edwards Lifesciences
1 program
Tricuspid valve repairN/A1 trial
Active Trials
NCT01246947Completed57Est. Feb 2017
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
bilateral erector spinae plane block with 30 mL 0.25 % bupivacaineN/A1 trial
Active Trials
NCT04928521CompletedEst. Oct 2021
Grifols
GrifolsNEW YORK, NY
1 program
AT-IIIPHASE_21 trial
Active Trials
NCT02037555Completed425Est. Jan 2018
Cellphire Therapeutics
1 program
Human plateletsPHASE_2_31 trial
Active Trials
NCT04709705Completed161Est. May 2025
Bristol Myers Squibb
1 program
PentaspanPHASE_2_31 trial
Active Trials
NCT00337805Completed240Est. Apr 2008

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Fresenius KabiHES 130/0.4
Angeles TherapeuticsAcute normovolemic hemodilution
Fresenius KabiL-Alanyl/L-Glutamine
Cellphire TherapeuticsHuman platelets
Nordic PharmaRopivacaine
Bristol Myers SquibbPentaspan
StrykerRapr Rounds Hyper/Hypothermia Wraps
GrifolsAT-III
Innovation PharmaceuticalsSelf-swabbing of surgical wound
City Therapeuticsbilateral erector spinae plane block with 30 mL 0.25 % bupivacaine
Shield TherapeuticsComfort Coach
Zimmer BiometSternalock 360 sternal plating system
MedtronicActivated clotting time versus blood-heparin concentration
Edwards LifesciencesTricuspid valve repair

Clinical Trials (14)

Total enrollment: 1,446 patients across 14 trials

NCT00860405Fresenius KabiHES 130/0.4

Voluven® in Paediatric Patients

Start: Mar 2009Est. completion: Dec 201061 patients
Phase 4Completed
NCT05049590Angeles TherapeuticsAcute normovolemic hemodilution

Acute Normovolemic Hemodilution in Complex Cardiac Surgery

Start: Feb 2022Est. completion: Jun 202363 patients
Phase 3Completed
NCT04019184Fresenius KabiL-Alanyl/L-Glutamine

Reduction of Occurence of Acute Kidney Injury (AKI) Through Administration of Glutamine

Start: Jul 2019Est. completion: May 202064 patients
Phase 3Completed
NCT04709705Cellphire TherapeuticsHuman platelets

DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)

Start: Oct 2021Est. completion: May 2025161 patients
Phase 2/3Completed
NCT00586976Nordic PharmaRopivacaine

A Phase II/III Study of Continuous Local Anesthetic Infusion in Median Sternotomy Following Cardiac Surgery

Start: Jul 2005Est. completion: Jun 2008125 patients
Phase 2/3Terminated
NCT00337805Bristol Myers SquibbPentaspan

Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery

Start: Sep 2004Est. completion: Apr 2008240 patients
Phase 2/3Completed
NCT03947671StrykerRapr Rounds Hyper/Hypothermia Wraps

Active Temperature Management After Cardiac Surgery and Its Effect on Postoperative Cognitive Dysfunction

Start: Jan 2020Est. completion: Oct 20260
Phase 2Withdrawn
NCT02037555GrifolsAT-III

Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass

Start: Jun 2014Est. completion: Jan 2018425 patients
Phase 2Completed
NCT07200401Innovation PharmaceuticalsSelf-swabbing of surgical wound

Exploring if Patients Can Safely and Easily Swab Their Own Surgical Wounds at Home

Start: Jan 2026Est. completion: Feb 202640 patients
N/ARecruiting
NCT04928521City Therapeuticsbilateral erector spinae plane block with 30 mL 0.25 % bupivacaine

Erector Spinae Plane (ESP) Block With 20 ml Versus 30 ml in Cardiac Surgery

Start: Jun 2021Est. completion: Oct 2021
N/ACompleted
NCT04051021Shield TherapeuticsComfort Coach

Non-Pharmacological Interventions on Patient Experience and Healthcare Utilization in Adult Cardiac Surgery Patients

Start: Sep 2019Est. completion: Jan 2021160 patients
N/ACompleted
NCT03282578Zimmer BiometSternalock 360 sternal plating system

Sternalock Versus Wires for Sternal Closure Study

Start: Oct 2017Est. completion: Nov 201850 patients
N/ACompleted
NCT01462968MedtronicActivated clotting time versus blood-heparin concentration

Interruptions in the Coagulationsystem in Relation With Cardiac Surgery - A Study Comparing Two Heparinization Strategies During On-pump Cardiac Surgery

Start: Nov 2011Est. completion: Mar 20120
N/AWithdrawn
NCT01246947Edwards LifesciencesTricuspid valve repair

Tricuspid Annuloplasty for Moderate Tricuspid Regurgitation Associated With Miral Operation

Start: Sep 2010Est. completion: Feb 201757 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 1,446 patients
14 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.