Cardiac Surgery

5
Pipeline Programs
5
Companies
6
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
2
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
2 programs
1
1
HES 130/0.4Phase 41 trial
L-Alanyl/L-GlutaminePhase 31 trial
Active Trials
NCT04019184Completed64Est. May 2020
NCT00860405Completed61Est. Dec 2010
Cellphire Therapeutics
1 program
1
Human plateletsPhase 2/31 trial
Active Trials
NCT04709705CompletedEst. May 2025
Bristol Myers Squibb
1 program
1
PentaspanPhase 2/31 trial
Active Trials
NCT00337805Completed240Est. Apr 2008
Grifols
GrifolsNEW YORK, NY
1 program
1
AT-IIIPhase 21 trial
Active Trials
NCT02037555CompletedEst. Jan 2018
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
bilateral erector spinae plane block with 30 mL 0.25 % bupivacaineN/A1 trial
Active Trials
NCT04928521CompletedEst. Oct 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Fresenius KabiHES 130/0.4
Fresenius KabiL-Alanyl/L-Glutamine
Cellphire TherapeuticsHuman platelets
Bristol Myers SquibbPentaspan
GrifolsAT-III
City Therapeuticsbilateral erector spinae plane block with 30 mL 0.25 % bupivacaine

Clinical Trials (6)

Total enrollment: 365 patients across 6 trials

NCT00860405Fresenius KabiHES 130/0.4

Voluven® in Paediatric Patients

Start: Mar 2009Est. completion: Dec 201061 patients
Phase 4Completed
NCT04019184Fresenius KabiL-Alanyl/L-Glutamine

Reduction of Occurence of Acute Kidney Injury (AKI) Through Administration of Glutamine

Start: Jul 2019Est. completion: May 202064 patients
Phase 3Completed
NCT04709705Cellphire TherapeuticsHuman platelets

DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)

Start: Oct 2021Est. completion: May 2025
Phase 2/3Completed
NCT00337805Bristol Myers SquibbPentaspan

Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery

Start: Sep 2004Est. completion: Apr 2008240 patients
Phase 2/3Completed
NCT02037555GrifolsAT-III

Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass

Start: Jun 2014Est. completion: Jan 2018
Phase 2Completed
NCT04928521City Therapeuticsbilateral erector spinae plane block with 30 mL 0.25 % bupivacaine

Erector Spinae Plane (ESP) Block With 20 ml Versus 30 ml in Cardiac Surgery

Start: Jun 2021Est. completion: Oct 2021
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
5 companies competing in this space