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Bronchiolitis

6
Pipeline Programs
7
Companies
9
Clinical Trials
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
0
1
1
3
Early DiscoveryClinical DevelopmentMarket

On Market (3)

Approved therapies currently available

INOMAXApproved
nitric oxide
Unknown Company
Vasodilator [EPC]inhalation1999
GENOSYLApproved
nitric oxide
Unknown Company
Vasodilator [EPC]inhalation2019
ULSPIRAApproved
nitric oxide
Unknown Company
Vasodilator [EPC]inhalation2023

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Beyond Air
Beyond AirIsrael - Rehovot
2 programs
1
1
Nitric OxidePhase 31 trial
Nitric OxidePhase 1/21 trial
Active Trials
NCT01768884Completed43Est. Jan 2016
NCT03053388Completed69Est. Apr 2018
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
1
Nebulized 3% salinePhase 2/31 trial
Active Trials
NCT00619918Completed447Est. May 2011
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
2 programs
3% Nebulized Hypertonic SalineN/A1 trial
De-implementation Strategy for BronchiolitisN/A1 trial
Active Trials
NCT02834819Terminated18Est. Sep 2015
NCT04302207Completed20,000Est. Jun 2024
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Continuous pulse oximetry monitoringN/A1 trial
Active Trials
NCT01014910CompletedEst. Sep 2014
Philips
PhilipsNetherlands - Amsterdam
1 program
Cough AssistN/A1 trial
Active Trials
NCT01757496Terminated1Est. Oct 2018
Pulmocide
PulmocideUK - London
1 program
Nasal and Bronchial SamplingN/A1 trial
Active Trials
NCT03062917Completed152Est. Jun 2018
Hamilton medical
Hamilton medicalSwitzerland - Bonaduz
1 program
The new HFNC weaning protocolN/A1 trial
Active Trials
NCT06621641Completed150Est. Jun 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Beyond AirNitric Oxide
Angeles TherapeuticsNebulized 3% saline
Beyond AirNitric Oxide
Hamilton medicalThe new HFNC weaning protocol
Colorado TherapeuticsDe-implementation Strategy for Bronchiolitis
PulmocideNasal and Bronchial Sampling
Colorado Therapeutics3% Nebulized Hypertonic Saline
PhilipsCough Assist
City TherapeuticsContinuous pulse oximetry monitoring

Clinical Trials (9)

Total enrollment: 20,880 patients across 9 trials

NCT03053388Beyond AirNitric Oxide

Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis

Start: Mar 2017Est. completion: Apr 201869 patients
Phase 3Completed
NCT00619918Angeles TherapeuticsNebulized 3% saline

Nebulized Hypertonic Saline for Bronchiolitis

Start: Feb 2008Est. completion: May 2011447 patients
Phase 2/3Completed
NCT01768884Beyond AirNitric Oxide

Evaluation of the Safety and Tolerability of Nitric Oxide (NO) Via Inhalation to Subjects With Bronchiolitis

Start: Jan 2013Est. completion: Jan 201643 patients
Phase 1/2Completed
NCT06621641Hamilton medicalThe new HFNC weaning protocol

Nurse-led High-flow Nasal Cannula Weaning Protocol in Pediatric Intensive Care Unit

Start: Oct 2024Est. completion: Jun 2025150 patients
N/ACompleted
NCT04302207Colorado TherapeuticsDe-implementation Strategy for Bronchiolitis

The ROUTT-B (Reduce Over-Utilized Tests and Treatments in Bronchiolitis) Study

Start: Sep 2020Est. completion: Jun 202420,000 patients
N/ACompleted
NCT03062917PulmocideNasal and Bronchial Sampling

Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis

Start: Oct 2015Est. completion: Jun 2018152 patients
N/ACompleted
NCT02834819Colorado Therapeutics3% Nebulized Hypertonic Saline

Nebulized 3% Hypertonic Saline vs. Standard of Care in Patients With Bronchiolitis

Start: Sep 2013Est. completion: Sep 201518 patients
N/ATerminated
NCT01757496PhilipsCough Assist

Cough Assist in Bronchiolitis

Start: Sep 2012Est. completion: Oct 20181 patients
N/ATerminated
NCT01014910City TherapeuticsContinuous pulse oximetry monitoring

Intermittent Versus Continuous Pulse Oximetry Monitoring of Infants Admitted for Bronchiolitis

Start: Dec 2009Est. completion: Sep 2014
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
7 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.