Skip to main content

Bronchiectasis

24
Pipeline Programs
22
Companies
35
Clinical Trials
6 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
2
8
0
9
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
4100%
+ 41 programs with unclassified modality

On Market (1)

Approved therapies currently available

Bayer
CIPROApproved
ciprofloxacin
Bayer
oral1997
396K Part D

Competitive Landscape

21 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
5 programs
1
2
2
1
CiprofloxacinPhase 3Small Molecule
Ciprofloxacin DPIPhase 3
BAY85-8501Phase 21 trial
CiprofloxacinPhase 2Small Molecule
T-326 InhalerPhase 1
Active Trials
NCT01818544Completed94Est. Jun 2014
Sunshine Biopharma
Sunshine BiopharmaQC - Varennes
1 program
1
Ceftolozane/tazobactamPhase 41 trial
Active Trials
NCT06035055Unknown30Est. Jan 2024
Sandoz
SandozAustria - Kundl
5 programs
1
2
2
CiprofloxacinPhase 3Small Molecule
Ciprofloxacin DPIPhase 3
CiprofloxacinPhase 2Small Molecule
QBW251Phase 2
T-326 InhalerPhase 1
Syntara
SyntaraAustralia - Frenchs Forest
4 programs
1
2
Inhaled mannitolPhase 31 trial
MannitolPhase 31 trial
mannitolPhase 1/21 trial
Inspiratory Flow and Volumes in BronchiectaticsN/A1 trial
Active Trials
NCT00656565Completed15Est. Jul 2008
NCT01076491Completed10Est. Apr 2009
NCT00669331Completed485Est. Jan 2014
+1 more trials
Kite Pharma
Kite PharmaCA - El Segundo
3 programs
1
2
AZLIPhase 31 trial
AZLIPhase 31 trial
AZLIPhase 21 trial
Active Trials
NCT00805025Completed89Est. Oct 2009
NCT01314716Completed274Est. Jul 2013
NCT01313624Completed266Est. Jun 2013
Chiesi
ChiesiBrazil - Santana de Parnaíba
2 programs
1
1
Formoterol-beclomethasonePhase 31 trial
CHF6333Phase 1/21 trial
Active Trials
NCT06166056Recruiting45Est. Aug 2026
NCT03846570Terminated34Est. Jul 2022
ViiV Healthcare
ViiV HealthcareNC - Durham
3 programs
1
1
GSK3862995BPhase 2
GSK2793660 solutionPhase 1
BronchoscopyN/A
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
2 programs
2
AZD5069Phase 22 trials
AZD9668Phase 21 trial
Active Trials
NCT02499328Completed340Est. Oct 2025
NCT01255592Completed83Est. Feb 2012
NCT00769119Completed38Est. Apr 2009
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
3 programs
Pseudomonas aeruginosa colonization infectionN/A1 trial
inapplicableN/A1 trial
inapplicableN/A1 trial
Active Trials
NCT05731427Recruiting150Est. Dec 2030
NCT07291167Not Yet Recruiting300Est. Dec 2030
NCT06344000Recruiting300Est. Apr 2027
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
BI 1291583PHASE_21 trial
BI 1291583PHASE_21 trial
BI 1291583PHASE_31 trial
Active Trials
NCT05846230Active Not Recruiting268Est. Mar 2027
NCT05238675Completed322Est. May 2024
NCT06872892Recruiting1,755Est. Oct 2028
Trudell Medical
Trudell MedicalON - London
2 programs
Active Cycle of Breathing TechniqueN/A1 trial
Development of a Canadian Bronchiectasis and NTM DatabaseN/A
Active Trials
NCT07037303Not Yet Recruiting100Est. Jul 2028
Insmed
InsmedBRIDGEWATER, NJ
2 programs
Development of a Canadian Bronchiectasis and NTM DatabaseN/A1 trial
280 mg Arikayce™PHASE_21 trial
Active Trials
NCT06144996Recruiting2,000Est. Jan 2050
NCT00775138Completed64Est. May 2009
Novartis
NovartisBASEL, Switzerland
2 programs
T-326 InhalerPHASE_11 trial
QBW251PHASE_25 trials
Active Trials
NCT02563197Completed33Est. Apr 2016
NCT04396366Terminated42Est. Jun 2023
NCT04268823Terminated54Est. Sep 2022
+3 more trials
Delve Therapeutics
Delve TherapeuticsNY - New York
1 program
BiWaze Clear SystemN/A1 trial
Active Trials
NCT06926881Recruiting85Est. Aug 2026
GSK
GSKLONDON, United Kingdom
1 program
BronchoscopyN/A1 trial
Active Trials
NCT03750734Completed13Est. Aug 2021
Baxter International
1 program
High Frequency Chest Wall OscillationN/A1 trial
Active Trials
NCT04017312Terminated43Est. Aug 2024
Baxter
BaxterCosta Rica - Cartago
1 program
High Frequency Chest Wall OscillationN/A
Electromed
ElectromedMN - New Prague
1 program
SmartVest Airway Clearance SystemN/A1 trial
Active Trials
NCT04271969Completed25Est. Dec 2023
Esteve
EsteveSpain - Barcelona
1 program
budesonide-formoterol single inhalerN/A1 trial
Active Trials
NCT00728715Completed40Est. Jan 2005
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
inhaled corticosteroid therapyN/A1 trial
Active Trials
NCT02714283Completed90,089Est. Jul 2018
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
1 program
AZLIPHASE_3

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Sunshine BiopharmaCeftolozane/tazobactam
Boehringer IngelheimBI 1291583
ChiesiFormoterol-beclomethasone
Kite PharmaAZLI
Kite PharmaAZLI
SyntaraInhaled mannitol
SyntaraMannitol
Boehringer IngelheimBI 1291583
Boehringer IngelheimBI 1291583
NovartisQBW251
NovartisQBW251
NovartisQBW251
NovartisQBW251
BayerBAY85-8501
AstraZenecaAZD5069

Showing 15 of 35 trials with date data

Clinical Trials (35)

Total enrollment: 99,059 patients across 35 trials

NCT06035055Sunshine BiopharmaCeftolozane/tazobactam

Ceftolozane/Tazobactam Continuous Infusion for Infective Exacerbations of Cystic Fibrosis and Bronchiectasis

Start: Oct 2023Est. completion: Jan 202430 patients
Phase 4Unknown

The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis

Start: Jun 2025Est. completion: Oct 20281,755 patients
Phase 3Recruiting
NCT03846570ChiesiFormoterol-beclomethasone

Formoterol-beclomethasone in Patients With Bronchiectasis: a Randomized Controlled Trial

Start: Jan 2019Est. completion: Jul 202234 patients
Phase 3Terminated

Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis

Start: Apr 2011Est. completion: Jun 2013266 patients
Phase 3Completed

Safety and Effectiveness of AZLI (an Inhaled Antibiotic) in Adults With Non-Cystic Fibrosis Bronchiectasis

Start: Apr 2011Est. completion: Jul 2013274 patients
Phase 3Completed
NCT00669331SyntaraInhaled mannitol

Inhaled Mannitol as a Mucoactive Therapy for Bronchiectasis

Start: Nov 2009Est. completion: Jan 2014485 patients
Phase 3Completed

Safety and Efficacy of Bronchitol in Bronchiectasis

Start: Mar 2006Est. completion: Jul 2008354 patients
Phase 3Completed

Clairleafᵀᴹ: A Study to Test Long-term Treatment With BI 1291583 in People With Bronchiectasis Who Took Part in a Previous Study With This Medicine

Start: Sep 2023Est. completion: Mar 2027268 patients
Phase 2Active Not Recruiting

A Study to Test Whether Different Doses of BI 1291583 Help People With Bronchiectasis

Start: Apr 2022Est. completion: May 2024322 patients
Phase 2Completed

Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

Start: Feb 2021Est. completion: Jun 202342 patients
Phase 2Terminated

Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Start: Sep 2020Est. completion: Sep 202254 patients
Phase 2Terminated

Dose-range Finding Efficacy and Safety Study for QBW251 in COPD Patients

Start: Sep 2019Est. completion: Feb 2022974 patients
Phase 2Completed

A Safety, Tolerability and Efficacy Study With QBW251 in COPD Patients With QBW251

Start: Apr 2015Est. completion: Jan 201792 patients
Phase 2Completed

Safety and Efficacy of Oral BAY85-8501 in Patients With Non-CF (Cystic Fibrosis) Bronchiectasis

Start: Apr 2013Est. completion: Jun 201494 patients
Phase 2Completed

Evaluation of the Effect of AZD5069 in Patients With Bronchiectasis

Start: Feb 2011Est. completion: Feb 201283 patients
Phase 2Completed

Evaluation of the Quality of Life Questionnaire-Bronchiectasis (QOL-B) in Patients With Bronchiectasis

Start: Dec 2008Est. completion: Oct 200989 patients
Phase 2Completed

A Phase II , Placebo-controlled Study to Assess Efficacy of 28 Day Oral AZD9668 in Patients With Bronchiectasis

Start: Sep 2008Est. completion: Apr 200938 patients
Phase 2Completed
NCT00775138Insmed280 mg Arikayce™

Safety and Tolerability Study of 2 Dose Level of Arikayce™ in Patients With Bronchiectasis and Chronic Infection Due to Pseudomonas Aeruginosa.

Start: Jun 2008Est. completion: May 200964 patients
Phase 2Completed

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled CHF6333 After Single Doses in Healthy Volunteers and After Single and Repeated Doses in Subjects With Bronchiectasis

Start: Nov 2023Est. completion: Aug 202645 patients
Phase 1/2Recruiting

Study to Assess MEDI4736 With Either AZD9150 or AZD5069 in Advanced Solid Tumors & Relapsed Metastatic Squamous Cell Carcinoma of Head & Neck

Start: Aug 2015Est. completion: Oct 2025340 patients
Phase 1/2Completed

Safety, Tolerability, Pharmacokinetics, and Preliminary Pharmacodynamics of QBW251 in Healthy Subjects and Cystic Fibrosis Patients

Start: Jul 2012Est. completion: Nov 2015153 patients
Phase 1/2Terminated

High Dose Inhaled Mannitol Study

Start: Jan 2009Est. completion: Apr 200910 patients
Phase 1/2Completed
NCT02563197NovartisT-326 Inhaler

Inhalation Flow Rate-study

Start: Nov 2015Est. completion: Apr 201633 patients
Phase 1Completed

Study on the Correlation Between Metabolomics and Anxiety and Depression in Bronchiectasis

Start: Dec 2025Est. completion: Dec 2030300 patients
N/ANot Yet Recruiting
NCT07037303Trudell MedicalActive Cycle of Breathing Technique

Comparing Active Cycle of Breathing Techniques (ACBT) and Aerobika in Treating Bronchiectasis in Korea

Start: Jul 2025Est. completion: Jul 2028100 patients
N/ANot Yet Recruiting

OLE Therapy With BE Patients in Home Care Study

Start: May 2025Est. completion: Aug 202685 patients
N/ARecruiting

Study on Disease Progression and Nutritional Status in Bronchiectasis

Start: Apr 2024Est. completion: Apr 2027300 patients
N/ARecruiting
NCT06144996InsmedDevelopment of a Canadian Bronchiectasis and NTM Database

Development of a Canadian Bronchiectasis and NTM Database

Start: Jan 2023Est. completion: Jan 20502,000 patients
N/ARecruiting
NCT05731427UNION therapeuticsPseudomonas aeruginosa colonization infection

Research on the Mechanism Affecting Progression of Bronchiectasis

Start: Feb 2021Est. completion: Dec 2030150 patients
N/ARecruiting
NCT04271969ElectromedSmartVest Airway Clearance System

Clinical Effectiveness Of High Frequency Chest Wall Oscillation (HFCWO) In A Bronchiectasis Population

Start: Feb 2020Est. completion: Dec 202325 patients
N/ACompleted
NCT03750734GSKBronchoscopy

Target Validation and Discovery in Idiopathic Bronchiectasis

Start: Sep 2019Est. completion: Aug 202113 patients
N/ACompleted
NCT04017312Baxter InternationalHigh Frequency Chest Wall Oscillation

A Pilot Study to Evaluate the Use of the Vest® System for Treatment of Bronchiectasis Patients in the Home Setting

Start: Aug 2019Est. completion: Aug 202443 patients
N/ATerminated
NCT02714283Oregon Therapeuticsinhaled corticosteroid therapy

Comparative Effectiveness and Safety of Inhaled Corticosteroids and Antimicrobial Compounds for Non-CF Bronchiectasis

Start: Oct 2016Est. completion: Jul 201890,089 patients
N/ACompleted
NCT00656565SyntaraInspiratory Flow and Volumes in Bronchiectatics

Inspiratory Flow and Volumes in Bronchiectatics

Start: Jun 2008Est. completion: Jul 200815 patients
N/ACompleted
NCT00728715Estevebudesonide-formoterol single inhaler

Efficacy of Budesonide-Formoterol in Bronchiectasis

Start: Jan 2004Est. completion: Jan 200540 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

9 late-stage (Phase 3) programs, potential near-term approvals
6 actively recruiting trials targeting 99,059 patients
22 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.