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B-Cell Malignancies

8
Pipeline Programs
8
Companies
15
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
3
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
450%
Vaccine
225%
Monoclonal Antibody
225%
+ 5 programs with unclassified modality

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Incyte
IncyteDE - Wilmington
4 programs
1
2
1
ParsaclisibPhase 2Small Molecule1 trial
NivolumabPhase 1/2Monoclonal Antibody
ParsaclisibPhase 1/2Small Molecule1 trial
INCB040093Phase 11 trial
Active Trials
NCT01905813Completed121Est. Feb 2026
NCT02018861Completed88Est. Apr 2021
NCT04509700Active Not Recruiting112Est. Nov 2026
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD5492Phase 1/21 trial
Active Trials
NCT06542250Recruiting174Est. Dec 2029
Kite Pharma
Kite PharmaCA - El Segundo
2 programs
1
TirabrutinibPhase 1Small Molecule1 trial
Influenza VaccineN/AVaccine1 trial
Active Trials
NCT03701438Terminated2Est. Oct 2019
NCT02457598Terminated203Est. Sep 2024
TransThera Sciences
TransThera SciencesChina - Nanjing
2 programs
2
TT-01488Phase 11 trial
TT-01488 TabletsPhase 11 trial
Active Trials
NCT05275504Unknown37Est. Apr 2023
NCT05683717Recruiting37Est. Oct 2028
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
1 program
Influenza VaccineN/AVaccine
Eureka Therapeutics
Eureka TherapeuticsCA - Emeryville
1 program
Low dose ET019002- T CellsPHASE_11 trial
Active Trials
NCT03642496Unknown18Est. Sep 2020
Bristol Myers Squibb
1 program
UrelumabPHASE_1Monoclonal Antibody5 trials
Active Trials
NCT03431948Completed60Est. Apr 2022
NCT02252263Completed44Est. Oct 2017
NCT02253992Terminated232Est. May 2019
+2 more trials
BeOne Medicines
BeOne MedicinesCA - San Carlos
1 program
ZanubrutinibPHASE_3Small Molecule1 trial
Active Trials
NCT04170283Active Not Recruiting955Est. Dec 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
BeOne MedicinesZanubrutinib
IncyteParsaclisib
AstraZenecaAZD5492
IncyteParsaclisib
Bristol Myers SquibbUrelumab
TransThera SciencesTT-01488 Tablets
TransThera SciencesTT-01488
Eureka TherapeuticsLow dose ET019002- T Cells
Bristol Myers SquibbUrelumab
Kite PharmaTirabrutinib
Bristol Myers SquibbUrelumab
Bristol Myers SquibbUrelumab
IncyteINCB040093
Bristol Myers SquibbUrelumab
Kite PharmaInfluenza Vaccine

Clinical Trials (15)

Total enrollment: 2,196 patients across 15 trials

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

Start: Jan 2020Est. completion: Dec 2026955 patients
Phase 3Active Not Recruiting

Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

Start: Aug 2020Est. completion: Nov 2026112 patients
Phase 2Active Not Recruiting

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

Start: Sep 2024Est. completion: Dec 2029174 patients
Phase 1/2Recruiting

A Phase 1/2, Open-Label, Dose Escalation, Safety and Tolerability Study of INCB050465 and Itacitinib in Subjects With Previously Treated B-Cell Malignancies (CITADEL-101)

Start: Sep 2016Est. completion: Apr 202188 patients
Phase 1/2Completed

An Investigational Immuno-therapy Study to Determine the Safety of Urelumab Given in Combination With Nivolumab in Solid Tumors and B-cell Non-Hodgkin's Lymphoma

Start: Sep 2014Est. completion: May 2019232 patients
Phase 1/2Terminated

A Phase 1 Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies

Start: Mar 2023Est. completion: Oct 202837 patients
Phase 1Recruiting

Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies

Start: Jun 2022Est. completion: Apr 202337 patients
Phase 1Unknown
NCT03642496Eureka TherapeuticsLow dose ET019002- T Cells

Clinical Study of ET019002-T Cell Therapy for Refractory/Relapsed B-Cell Malignancies

Start: Aug 2018Est. completion: Sep 202018 patients
Phase 1Unknown

Stereotactic Body Radiotherapy (SBRT) Plus Immunotherapy for Cancer

Start: Mar 2018Est. completion: Apr 202260 patients
Phase 1Completed

Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies

Start: Jun 2015Est. completion: Sep 2024203 patients
Phase 1Terminated

A Phase I Open Label Study of the Safety and Tolerability of Elotuzumab (BMS-901608) Administered in Combination With Either Lirilumab (BMS-986015) or Urelumab (BMS-663513) in Subjects With Multiple Myeloma

Start: Dec 2014Est. completion: Oct 201744 patients
Phase 1Completed

Combination Study of Urelumab and Cetuximab in Patients With Advanced/Metastatic Colorectal Cancer or Advanced/Metastatic Head and Neck Cancer

Start: Apr 2014Est. completion: Dec 201666 patients
Phase 1Completed

Study of INCB040093 in Subjects With Previously Treated B-Cell Malignancies

Start: Jun 2013Est. completion: Feb 2026121 patients
Phase 1Completed

Combination Study of Urelumab and Rituximab in Patients With B-cell Non-Hodgkins Lymphoma

Start: Mar 2013Est. completion: Aug 201647 patients
Phase 1Completed
NCT03701438Kite PharmaInfluenza Vaccine

Immune Response to Influenza Vaccine in Adults With B-cell Malignancies Treated With Idelalisib

Start: Oct 2018Est. completion: Oct 20192 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 2,196 patients
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.