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B-Cell Malignancies

8
Pipeline Programs
8
Companies
14
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
3
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
450%
Vaccine
225%
Monoclonal Antibody
225%
+ 5 programs with unclassified modality

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Incyte
IncyteDE - Wilmington
4 programs
1
2
1
ParsaclisibPhase 2Small Molecule1 trial
NivolumabPhase 1/2Monoclonal Antibody
ParsaclisibPhase 1/2Small Molecule1 trial
INCB040093Phase 11 trial
Active Trials
NCT01905813Active Not Recruiting121Est. Apr 2026
NCT02018861Completed88Est. Apr 2021
NCT04509700Active Not Recruiting112Est. Sep 2027
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
1
AZD5492Phase 1/21 trial
Active Trials
NCT06542250Recruiting174Est. Feb 2028
Kite Pharma
Kite PharmaCA - El Segundo
2 programs
1
TirabrutinibPhase 1Small Molecule1 trial
Influenza VaccineN/AVaccine1 trial
Active Trials
NCT03701438Terminated2Est. Oct 2019
NCT02457598Terminated203Est. Sep 2024
TransThera Sciences
TransThera SciencesChina - Nanjing
2 programs
2
TT-01488Phase 11 trial
TT-01488 TabletsPhase 11 trial
Active Trials
NCT05275504Unknown37Est. Apr 2023
NCT05683717Recruiting37Est. Oct 2028
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
1 program
Influenza VaccineN/AVaccine
Eureka Therapeutics
Eureka TherapeuticsCA - Emeryville
1 program
Low dose ET019002- T CellsPHASE_11 trial
Active Trials
NCT03642496Unknown18Est. Sep 2020
Bristol Myers Squibb
1 program
UrelumabPHASE_1Monoclonal Antibody5 trials
Active Trials
NCT03431948Completed60Est. Apr 2022
NCT02252263Completed44Est. Oct 2017
NCT02253992Terminated232Est. May 2019
+2 more trials
BeOne Medicines
BeOne MedicinesCA - San Carlos
1 program
ZanubrutinibPHASE_3Small Molecule

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
IncyteParsaclisib
AstraZenecaAZD5492
IncyteParsaclisib
Bristol Myers SquibbUrelumab
TransThera SciencesTT-01488 Tablets
TransThera SciencesTT-01488
Eureka TherapeuticsLow dose ET019002- T Cells
Bristol Myers SquibbUrelumab
Kite PharmaTirabrutinib
Bristol Myers SquibbUrelumab
Bristol Myers SquibbUrelumab
IncyteINCB040093
Bristol Myers SquibbUrelumab
Kite PharmaInfluenza Vaccine

Clinical Trials (14)

Total enrollment: 1,241 patients across 14 trials

Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465)

Start: Aug 2020Est. completion: Sep 2027112 patients
Phase 2Active Not Recruiting

A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

Start: Sep 2024Est. completion: Feb 2028174 patients
Phase 1/2Recruiting

A Phase 1/2, Open-Label, Dose Escalation, Safety and Tolerability Study of INCB050465 and Itacitinib in Subjects With Previously Treated B-Cell Malignancies (CITADEL-101)

Start: Sep 2016Est. completion: Apr 202188 patients
Phase 1/2Completed

An Investigational Immuno-therapy Study to Determine the Safety of Urelumab Given in Combination With Nivolumab in Solid Tumors and B-cell Non-Hodgkin's Lymphoma

Start: Sep 2014Est. completion: May 2019232 patients
Phase 1/2Terminated

A Phase 1 Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies

Start: Mar 2023Est. completion: Oct 202837 patients
Phase 1Recruiting

Study to Evaluate the Safety and Tolerability of TT-01488 in Patients With B-Cell Malignancies

Start: Jun 2022Est. completion: Apr 202337 patients
Phase 1Unknown
NCT03642496Eureka TherapeuticsLow dose ET019002- T Cells

Clinical Study of ET019002-T Cell Therapy for Refractory/Relapsed B-Cell Malignancies

Start: Aug 2018Est. completion: Sep 202018 patients
Phase 1Unknown

Stereotactic Body Radiotherapy (SBRT) Plus Immunotherapy for Cancer

Start: Mar 2018Est. completion: Apr 202260 patients
Phase 1Completed

Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies

Start: Jun 2015Est. completion: Sep 2024203 patients
Phase 1Terminated

A Phase I Open Label Study of the Safety and Tolerability of Elotuzumab (BMS-901608) Administered in Combination With Either Lirilumab (BMS-986015) or Urelumab (BMS-663513) in Subjects With Multiple Myeloma

Start: Dec 2014Est. completion: Oct 201744 patients
Phase 1Completed

Combination Study of Urelumab and Cetuximab in Patients With Advanced/Metastatic Colorectal Cancer or Advanced/Metastatic Head and Neck Cancer

Start: Apr 2014Est. completion: Dec 201666 patients
Phase 1Completed

Study of INCB040093 in Subjects With Previously Treated B-Cell Malignancies

Start: Jun 2013Est. completion: Apr 2026121 patients
Phase 1Active Not Recruiting

Combination Study of Urelumab and Rituximab in Patients With B-cell Non-Hodgkins Lymphoma

Start: Mar 2013Est. completion: Aug 201647 patients
Phase 1Completed
NCT03701438Kite PharmaInfluenza Vaccine

Immune Response to Influenza Vaccine in Adults With B-cell Malignancies Treated With Idelalisib

Start: Oct 2018Est. completion: Oct 20192 patients
N/ATerminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 actively recruiting trials targeting 1,241 patients
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.