Skip to main content

Appendicitis

4
Pipeline Programs
9
Companies
10
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
0
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
3100%
+ 8 programs with unclassified modality

On Market (1)

Approved therapies currently available

Pfizer
TYGACILApproved
tigecycline
Pfizer
Tetracycline-class Antibacterial [EPC]intravenous2005
85K Part D

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
2 programs
2
tigecyclinePhase 4Small Molecule1 trial
tigecyclinePhase 4Small Molecule1 trial
Active Trials
NCT00230971Completed473Est. Sep 2008
NCT00195351Completed467Est. Feb 2008
Partner Therapeutics
Partner TherapeuticsMA - Lexington
1 program
1
A combination of fosfomycin, metronidazole and GM-CSF i.p.Phase 21 trial
Active Trials
NCT03046758Completed14Est. Dec 2017
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
2 programs
Pediatric Appendicitis Pathway StudyN/A1 trial
laparoscopic appendectomyN/A
Active Trials
NCT01192620Completed178Est. Aug 2011
Mott
MottCT - Farmington
1 program
Non-operativeN/A1 trial
Active Trials
NCT02271932Unknown1,076Est. Nov 2023
Medtronic
MedtronicNJ - Phillipsburg
1 program
SILS appendectomyN/A1 trial
Active Trials
NCT00997516Terminated75Est. Jan 2014
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Single Incision Laparoscopic AppendectomyN/A1 trial
Active Trials
NCT00981136CompletedEst. Dec 2011
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
laparoscopic appendectomyN/A1 trial
Active Trials
NCT00554008Completed400Est. Jan 2011
GE HealthCare
1 program
Diagnostic CTPHASE_31 trial
Active Trials
NCT00913380Completed891Est. Apr 2011
Ortho Development
1 program
levofloxacin; metronidazolePHASE_4Small Molecule1 trial
Active Trials
NCT00236912Terminated139Est. Sep 2004

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Pfizertigecycline
Pfizertigecycline
Ortho Developmentlevofloxacin; metronidazole
GE HealthCareDiagnostic CT
Partner TherapeuticsA combination of fosfomycin, metronidazole and GM-CSF i.p.
MottNon-operative
Oregon TherapeuticsPediatric Appendicitis Pathway Study
MedtronicSILS appendectomy
City TherapeuticsSingle Incision Laparoscopic Appendectomy
Angeles Therapeuticslaparoscopic appendectomy

Clinical Trials (10)

Total enrollment: 3,713 patients across 10 trials

NCT00230971Pfizertigecycline

Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)

Start: Oct 2005Est. completion: Sep 2008473 patients
Phase 4Completed
NCT00195351Pfizertigecycline

Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection

Start: Sep 2005Est. completion: Feb 2008467 patients
Phase 4Completed
NCT00236912Ortho Developmentlevofloxacin; metronidazole

A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis

Start: Jul 2003Est. completion: Sep 2004139 patients
Phase 4Terminated
NCT00913380GE HealthCareDiagnostic CT

Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT

Start: Sep 2009Est. completion: Apr 2011891 patients
Phase 3Completed
NCT03046758Partner TherapeuticsA combination of fosfomycin, metronidazole and GM-CSF i.p.

The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis

Start: Feb 2017Est. completion: Dec 201714 patients
Phase 2Completed
NCT02271932MottNon-operative

Multi-institutional Trial of Non-operative Management of Appendicitis

Start: Oct 2014Est. completion: Nov 20231,076 patients
N/AUnknown
NCT01192620Oregon TherapeuticsPediatric Appendicitis Pathway Study

Pediatric Appendicitis Pathway Study

Start: Oct 2010Est. completion: Aug 2011178 patients
N/ACompleted
NCT00997516MedtronicSILS appendectomy

Single-incision Laparoscopic (SILS) Versus Conventional Laparoscopic Appendectomy for the Treatment of Acute Appendicitis

Start: May 2010Est. completion: Jan 201475 patients
N/ATerminated
NCT00981136City TherapeuticsSingle Incision Laparoscopic Appendectomy

Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Appendectomy

Start: Aug 2009Est. completion: Dec 2011
N/ACompleted
NCT00554008Angeles Therapeuticslaparoscopic appendectomy

Comparative Study of Laparoscopic Versus Open Appendectomy in Children

Start: Dec 2007Est. completion: Jan 2011400 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

9 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.