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Ankle Sprains

1
Pipeline Programs
5
Companies
5
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Teikoku Seiyaku
Teikoku SeiyakuJapan - Higashikagawa
1 program
1
Esflurbiprofen Topical SystemPhase 31 trial
Active Trials
NCT06866613Completed69Est. Oct 2025
Spine BioPharma
Spine BioPharmaNY - New York
1 program
Ankle BraceN/A1 trial
Active Trials
NCT03641066Completed20Est. Jan 2019
MTI
MTIUT - Salt Lake City
1 program
Biodex Balance SystemN/A1 trial
Active Trials
NCT04773990Completed50Est. Feb 2021
Physical Sciences
Physical SciencesMA - Andover
1 program
excercisesN/A1 trial
Active Trials
NCT06469099Completed786Est. Sep 2025
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Dexketoprofen Trometamol 50 Mg/mL Solution for InjectionPHASE_41 trial
Active Trials
NCT06563271CompletedEst. Jun 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
City TherapeuticsDexketoprofen Trometamol 50 Mg/mL Solution for Injection
Teikoku SeiyakuEsflurbiprofen Topical System
Physical Sciencesexcercises
MTIBiodex Balance System
Spine BioPharmaAnkle Brace

Clinical Trials (5)

Total enrollment: 925 patients across 5 trials

NCT06563271City TherapeuticsDexketoprofen Trometamol 50 Mg/mL Solution for Injection

Approach to Ankle Sprains in the Emergency Department

Start: Dec 2023Est. completion: Jun 2024
Phase 4Completed
NCT06866613Teikoku SeiyakuEsflurbiprofen Topical System

Phase III Trial to Evaluate the Efficacy and Safety in Patients With Ankle Sprains.

Start: Mar 2025Est. completion: Oct 202569 patients
Phase 3Completed
NCT06469099Physical Sciencesexcercises

Ankle Injuries, Imaging and Prevention Program Effectiveness in New Army Recruits

Start: Mar 2024Est. completion: Sep 2025786 patients
N/ACompleted
NCT04773990MTIBiodex Balance System

Efficacy of Balance Training by BBS on Gait Parameters and Balance in Patients With RLAS

Start: Oct 2020Est. completion: Feb 202150 patients
N/ACompleted
NCT03641066Spine BioPharmaAnkle Brace

Progressing Ankle Brace Restriction on Walking and Running Gait Characteristics in Healthy Individuals

Start: Apr 2018Est. completion: Jan 201920 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.