Angina

8
Pipeline Programs
3
Companies
21
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
4
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 8 programs with unclassified modality

On Market (1)

Approved therapies currently available

U
ASPRUZYO SPRINKLEApproved
ranolazine
Unknown Company
Anti-anginal [EPC]oral2022

Competitive Landscape

3 companies ranked by most advanced pipeline stage

GS
Gilead SciencesFOSTER CITY, CA
7 programs
1
4
1
RanolazinePhase 41 trial
RanolazinePhase 31 trial
RanolazinePhase 3
RanolazinePhase 3
RanolazinePhase 35 trials
+2 more programs
Active Trials
NCT03134105Withdrawn0Est. Jul 2018
NCT02147834Terminated5Est. Sep 2016
NCT01174173Completed11Est. Oct 2014
+6 more trials
Sandoz
SandozAustria - Kundl
1 program
1
AtenololPhase 1Small Molecule
Abbott
AbbottABBOTT PARK, IL
1 program
XIENCE V / PROMUS stentN/A1 trial
Active Trials
NCT01086228Completed2,010Est. Aug 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine
Gilead SciencesRanolazine

Showing 15 of 21 trials with date data

Clinical Trials (21)

Total enrollment: 4,040 patients across 21 trials

Effect of Ranolazine on Activity Level in Patients With Angina After FFR Based Deferred Intervention (REPTAR)

Start: Jan 2017Est. completion: Oct 201740 patients
Phase 4Unknown

Targeting Right Ventricle in Pulmonary Hypertension Gilead

Start: Jul 2016Est. completion: Jan 201822 patients
Phase 4Completed

Ranolazine for Diabetic Peripheral Neuropathic Pain (DPNP)

Start: May 2014Est. completion: Feb 20174 patients
Phase 4Terminated

Ranolazine and Microvascular Angina by PET in the Emergency Department

Start: Apr 2014Est. completion: Nov 201531 patients
Phase 4Completed

Effects of Ranolazine and Exercise on Daily Physical Activity Trial

Start: Dec 2013Est. completion: Oct 201638 patients
Phase 4Completed

Ranolazine, Ethnicity and the Metabolic Syndrome

Start: Jan 2011Est. completion: Nov 2013160 patients
Phase 4Unknown

An Open-label, Multi-center Study Evaluating the Validity, Reliability, and Responsiveness of a New Female-specific Angina Questionnaire in Women With Chronic Angina Treated With Ranolazine Extended-release Tablets (CVT 3041)

Start: Nov 2007Est. completion: Jan 2011172 patients
Phase 4Completed

Ranolazine for the Prevention of Atrial Fibrillation After Electrical Cardioversion

Start: Mar 2012Est. completion: Jun 201410 patients
Phase 3Terminated

Ranolazine When Added to Glimepiride in Subjects With Type 2 Diabetes Mellitus

Start: Jan 2012Est. completion: Aug 2013431 patients
Phase 3Completed

Ranolazine Monotherapy in Subjects With Type 2 Diabetes Mellitus

Start: Nov 2011Est. completion: Oct 2013465 patients
Phase 3Completed

Suppression Of Atrial Fibrillation With Ranolazine After Cardiac Surgery

Start: Sep 2010Est. completion: Nov 201215 patients
Phase 3Terminated

Ranolazine and Pulmonary Hypertension

Start: Jun 2010Est. completion: Oct 201411 patients
Phase 3Completed

Ranolazine SR in Patients With Chronic Angina Who Remain Symptomatic Despite Maximal Treatment With Amlodipine

Start: Aug 2004Est. completion: Feb 2005500 patients
Phase 3Completed

Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosis

Start: Jun 2018Est. completion: Dec 202214 patients
Phase 2Completed

Effectiveness of Ranolazine on Reducing Chest Pain in Patients With Blockage But no Stents

Start: Aug 2015Est. completion: Sep 20165 patients
Phase 2Terminated

Ranolazine Among Unrevascularized Chronic Stable Angina Patients

Start: Sep 2014Est. completion: Sep 201650 patients
Phase 2Completed

The Use of Ranolazine for Atrial Fibrillation and Diastolic Heart Failure

Start: Jun 2013Est. completion: Feb 20148 patients
Phase 2Terminated

Single Cohort 4-period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine

Start: Feb 2012Est. completion: Mar 201224 patients
Phase 1Completed
NCT03134105Gilead SciencesMonthly Feedback on activity and patient-reported angina

A Wearable EducAtional Intervention to REduce Angina

Start: Sep 2017Est. completion: Jul 20180
N/AWithdrawn

Impact of Ranolazine on Myocardial Ischemia Detected by High-Field 3T Cardiovascular Magnetic Resonance (CMR) Imaging and P-31 Spectroscopy

Start: Jun 2012Est. completion: Dec 201430 patients
N/AUnknown
NCT01086228AbbottXIENCE V / PROMUS stent

XIENCE V/PROMUS Everolimus-Eluting Stent System Post-marketing Surveillance Protocol for Japan

Start: Mar 2010Est. completion: Aug 20162,010 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
3 companies competing in this space