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Acute Myocardial Infarction

27
Pipeline Programs
30
Companies
50
Clinical Trials
2 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
11
1
5
7
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
267%
Small Molecule
133%
+ 59 programs with unclassified modality

On Market (1)

Approved therapies currently available

AstraZeneca
FARXIGAApproved
dapagliflozin
AstraZeneca
oral2014
4.3B Part D

Competitive Landscape

34 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
6 programs
1
3
Endeavor resolute or Resolute integrityPhase 41 trial
Implantable cardioverter defibrillatorPhase 41 trial
Tenecteplase + UFHPhase 41 trial
Single Site PacingPhase 21 trial
CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial InfarctionN/A1 trial
+1 more programs
Active Trials
NCT00145119Completed312Est. May 2007
NCT00704561Completed44Est. Oct 2009
NCT01213251Completed129Est. Apr 2016
+3 more trials
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
4 programs
1
1
Implantable cardioverter defibrillatorPhase 4
DapagliflozinPhase 3Small Molecule1 trial
FentanylN/A1 trial
Percutaneous coronary interventionN/A1 trial
Active Trials
NCT02531165Completed38Est. Feb 2018
NCT02806102Unknown13,000Est. Feb 2018
NCT04564742Completed4,017Est. Jul 2023
Autonomous Therapeutics
2 programs
1
Shexiang Baoxin PillPhase 41 trial
thrombolysisN/A1 trial
Active Trials
NCT04451967Unknown3,159Est. Sep 2022
NCT07153744Not Yet Recruiting9,588Est. Dec 2029
Boston Scientific
Boston ScientificCA - Valencia
1 program
1
Tenecteplase + UFHPhase 4
Sandoz
SandozAustria - Kundl
2 programs
1
LCZ696Phase 31 trial
French Cohort of Myocardial Infarction EvaluationN/A1 trial
Active Trials
NCT04050956Recruiting30,000Est. Mar 2049
NCT02924727Completed5,669Est. Feb 2021
Faraday Pharmaceuticals
2 programs
1
1
FDY-5301Phase 31 trial
FDY-5301Phase 21 trial
Active Trials
NCT03470441Completed120Est. Jan 2019
NCT04837001Completed2,351Est. Sep 2025
Innovation Pharmaceuticals
2 programs
1
1
SelatogrelPhase 31 trial
Selatogrel 8 mgPhase 21 trial
Active Trials
NCT03487445Completed48Est. Nov 2018
NCT04957719Enrolling By Invitation14,000Est. Dec 2026
Bharat Biotech
1 program
1
THR-100Phase 31 trial
Active Trials
NCT01305226Completed120Est. Aug 2011
Abbott
AbbottABBOTT PARK, IL
4 programs
1
Triage Profiler S.O.B. PanelPhase 2/31 trial
Cardiac troponin testingN/A1 trial
Coronary and peripheral stentsN/A1 trial
Selective intracoronary hypothermia + PPCIN/A1 trial
Active Trials
NCT03214029Active Not Recruiting2,000Est. Dec 2025
NCT04573660Recruiting3,784Est. Nov 2031
NCT03447834Unknown200Est. Jun 2023
+1 more trials
CSL Seqirus
CSL SeqirusUK - Maidenhead
3 programs
1
2
CSL112Phase 2
CSL_112Phase 2
CSL112Phase 1
ISU Abxis
1 program
1
AbciximabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03087539Unknown146Est. Jun 2017
Bayer
BayerLEVERKUSEN, Germany
1 program
1
BAY2433334Phase 21 trial
Active Trials
NCT04304534Completed1,601Est. Feb 2022
RegeneRx Biopharmaceuticals
1 program
1
Drug: PlaceboPhase 21 trial
Active Trials
NCT01311518Withdrawn0Est. Jul 2020
UNION therapeutics
1 program
1
Intravenous infusion placeboPhase 21 trial
Active Trials
NCT04551443Unknown200Est. Dec 2022
CellProthera
CellProtheraFrance - Mulhouse
1 program
1
PROTHERACYTESPhase 21 trial
Active Trials
NCT02669810Completed49Est. Mar 2024
Hope Pharmaceuticals
Hope PharmaceuticalsAZ - Scottsdale
1 program
1
Sodium NitritePhase 21 trial
Active Trials
NCT00924118Completed30Est. Jun 2016
Biocorp
2 programs
1
Allogeneic umbilical cord mesenchymal stem cellsPhase 11 trial
high-sensitivity cardiac troponin testingN/A1 trial
Active Trials
NCT05853042Active Not Recruiting1,500Est. May 2025
NCT04056819Completed10Est. Dec 2021
Healios
HealiosJapan - Tokyo
1 program
1
AMI MultiStem®Phase 11 trial
Active Trials
NCT00677222Completed25Est. Feb 2012
Zoll
ZollCA - San Jose
4 programs
COOL-AMI EU Case Series Clinical StudyN/A1 trial
Cooling + PCIN/A1 trial
Cooling Procedure using the ZOLL Thermogard XP3 IVTM SystemN/A1 trial
Intravascular permissive hypothermia as an adjunct to PCIN/A1 trial
Active Trials
NCT02070913Completed352Est. Apr 2019
NCT02509832Completed100Est. Jun 2018
NCT03361995Withdrawn0Est. May 2022
+1 more trials
Rhythm Pharmaceuticals
3 programs
CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial InfarctionN/A
Single Site PacingPHASE_2
Implantable cardioverter defibrillatorPHASE_4
CSL Behring
CSL BehringIL - Bradley
3 programs
CSL112PHASE_11 trial
CSL112PHASE_21 trial
CSL_112PHASE_21 trial
Active Trials
NCT02427035Completed32Est. Feb 2016
NCT02108262Completed1,267Est. Mar 2016
NCT02742103Completed83Est. Jun 2017
Siemens Healthineers
Siemens HealthineersGermany - Forchheim
2 programs
Cardiac Troponin TestingN/A1 trial
Cardiac Troponin TestingN/A1 trial
Active Trials
NCT04772157Completed1,000Est. Oct 2024
NCT04280926Completed1,000Est. Oct 2024
Eppendorf
EppendorfGermany - Hamburg
2 programs
Discharge homeN/A
Study for Evaluation of Newly Onset Chest Pain and Rapid Diagnosis of Myocardial NecrosisN/A1 trial
Active Trials
NCT03227159Completed1,818Est. Dec 2008
JW Pharmaceutical
2 programs
Livalo Acute Myocardial Infarction StudyN/A1 trial
Livalo Acute Myocardial Infarction Study (LAMIS)N/A1 trial
Active Trials
NCT00805714Completed1,128Est. Mar 2011
NCT01265706Completed1,000Est. Dec 2014
ResMed
ResMedSAN DIEGO, CA
1 program
Adaptive servo-ventilationN/A1 trial
Active Trials
NCT02093377Terminated79Est. Jun 2021
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Discharge homeN/A1 trial
Active Trials
NCT01498731Completed902Est. Jun 2013
Novartis
NovartisBASEL, Switzerland
1 program
French Cohort of Myocardial Infarction EvaluationN/A
Young BioPharma
1 program
Sacubitril / Valsartan Oral Tablet [Entresto]N/A1 trial
Active Trials
NCT03893435Completed192Est. Oct 2022
Biotronik
BiotronikGermany - Berlin
1 program
iFRN/A1 trial
Active Trials
NCT03298659Active Not Recruiting1,146Est. May 2027
Integrated Biosciences
1 program
thrombolysisN/A

+4 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Autonomous TherapeuticsShexiang Baoxin Pill
LabcorpPercutaneous Coronary Intervention
MedtronicEndeavor resolute or Resolute integrity
MedtronicTenecteplase + UFH
MedtronicImplantable cardioverter defibrillator
Faraday PharmaceuticalsFDY-5301
Innovation PharmaceuticalsSelatogrel
AstraZenecaDapagliflozin
SandozLCZ696
Bharat BiotechTHR-100
Boehringer Ingelheimenoxaparin
AbbottTriage Profiler S.O.B. Panel
Novo NordiskTocilizumab
UNION therapeuticsIntravenous infusion placebo
BayerBAY2433334

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 105,506 patients across 50 trials

NCT07153744Autonomous TherapeuticsShexiang Baoxin Pill

Efficacy and Safety of Shexiang Baoxin Pill(MUSKARDIA) in the Treatment of Acute Myocardial Infarction

Start: Sep 2025Est. completion: Dec 20299,588 patients
Phase 4Not Yet Recruiting
NCT02577965LabcorpPercutaneous Coronary Intervention

Optical Coherence Tomography Assessment of Gender diVersity In Primary Angioplasty: The OCTAVIA Trial

Start: Mar 2011Est. completion: Sep 2014140 patients
Phase 4Completed
NCT01156662MedtronicEndeavor resolute or Resolute integrity

Efficacy of Thrombosuction in Primary Percutaneous Coronary Intervention of Acute Myocardial Infarction

Start: Mar 2009Est. completion: Apr 20141,400 patients
Phase 4Unknown
NCT00257309MedtronicTenecteplase + UFH

Thrombolysis Versus Primary Angioplasty for AMI in Elderly Patients

Start: Apr 2005Est. completion: Dec 2008266 patients
Phase 4Terminated
NCT00157768MedtronicImplantable cardioverter defibrillator

IRIS : Use of Implantable Defibrillator in High-risk Patients Early After Acute Myocardial Infarction

Start: Jun 1999Est. completion: Oct 2007900 patients
Phase 4Completed
NCT04837001Faraday PharmaceuticalsFDY-5301

Evaluation in STEMI Patients Using FDY-5301

Start: May 2022Est. completion: Sep 20252,351 patients
Phase 3Completed
NCT04957719Innovation PharmaceuticalsSelatogrel

Selatogrel Outcome Study in Suspected Acute Myocardial Infarction

Start: Aug 2021Est. completion: Dec 202614,000 patients
Phase 3Enrolling By Invitation
NCT04564742AstraZenecaDapagliflozin

Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack.

Start: Dec 2020Est. completion: Jul 20234,017 patients
Phase 3Completed
NCT02924727SandozLCZ696

Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI

Start: Dec 2016Est. completion: Feb 20215,669 patients
Phase 3Completed
NCT01305226Bharat BiotechTHR-100

A Trial Using Double-Bolus THR-100 Versus Streptokinase

Start: Oct 2010Est. completion: Aug 2011120 patients
Phase 3Completed
NCT00882635Boehringer Ingelheimenoxaparin

The STREAM Percutaneous Coronary Intervention Anticoagulant Sub-study

Start: Oct 2008Est. completion: Jun 201244 patients
Phase 3Completed
NCT00206830AbbottTriage Profiler S.O.B. Panel

SHORTness of Breath In the Emergency Department (SHORTIE)

Start: Apr 2005Est. completion: Aug 2007306 patients
Phase 2/3Completed
NCT05350592Novo NordiskTocilizumab

Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock

Start: Mar 2022Est. completion: Sep 2025100 patients
Phase 2Active Not Recruiting
NCT04551443UNION therapeuticsIntravenous infusion placebo

WJMSCs Anti-inflammatory Therapy in Acute Myocardial Infarction

Start: Nov 2020Est. completion: Dec 2022200 patients
Phase 2Unknown
NCT04304534BayerBAY2433334

Study to Gather Information About the Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following an Acute Heart Attack

Start: Jun 2020Est. completion: Feb 20221,601 patients
Phase 2Completed
NCT01311518RegeneRx BiopharmaceuticalsDrug: Placebo

A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction

Start: Jul 2019Est. completion: Jul 20200
Phase 2Withdrawn
NCT03487445Innovation PharmaceuticalsSelatogrel 8 mg

A Medical Research Study to Evaluate the Effects of ACT-246475 in Adults With Heart Attack

Start: Jul 2018Est. completion: Nov 201848 patients
Phase 2Completed
NCT03470441Faraday PharmaceuticalsFDY-5301

A Study of Acute Myocardial Infarction Using FDY-5301

Start: Oct 2017Est. completion: Jan 2019120 patients
Phase 2Completed
NCT02742103CSL BehringCSL_112

A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction

Start: Aug 2016Est. completion: Jun 201783 patients
Phase 2Completed
NCT02669810CellProtheraPROTHERACYTES

EXCELLENT (EXpanded CELL ENdocardiac Transplantation)

Start: Feb 2016Est. completion: Mar 202449 patients
Phase 2Completed
NCT02108262CSL BehringCSL112

A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.

Start: Aug 2014Est. completion: Mar 20161,267 patients
Phase 2Completed
NCT03087539ISU AbxisAbciximab

Exploratory P2 Trial to Evaluate Efficacy and Safety of Clotinab® (Abciximab) in Acute MI Patients

Start: May 2013Est. completion: Jun 2017146 patients
Phase 2Unknown
NCT01213251MedtronicSingle Site Pacing

Post-Myocardial Infarction Remodeling Prevention Therapy

Start: Dec 2010Est. completion: Apr 2016129 patients
Phase 2Completed
NCT00924118Hope PharmaceuticalsSodium Nitrite

Sodium Nitrite in Acute Myocardial Infarction

Start: Jul 2009Est. completion: Jun 201630 patients
Phase 2Completed
NCT04056819BiocorpAllogeneic umbilical cord mesenchymal stem cells

Evaluate the Safety and Explore Efficacy of Umbilical Cord Mesenchymal Stem Cells in Acute Myocardial Infarction

Start: May 2019Est. completion: Dec 202110 patients
Phase 1Completed
NCT02427035CSL BehringCSL112

A Study of CSL112 in Healthy Adults and in Adults With Moderate Renal Impairment

Start: May 2015Est. completion: Feb 201632 patients
Phase 1Completed
NCT00677222HealiosAMI MultiStem®

Safety Study of AMI MultiStem® to Treat Heart Attacks

Start: May 2008Est. completion: Feb 201225 patients
Phase 1Completed
NCT05853042Biocorphigh-sensitivity cardiac troponin testing

MERITnI - Mindray-hs-cTnI Assay: Analytical and Clinical Evaluation for the Diagnosis and RIsk AssessmenT of Myocardial InfarctIon.

Start: Dec 2022Est. completion: May 20251,500 patients
N/AActive Not Recruiting
NCT04573660AbbottCoronary and peripheral stents

Abbott Vascular Medical Device Registry

Start: Oct 2020Est. completion: Nov 20313,784 patients
N/ARecruiting
NCT04280926Siemens HealthineersCardiac Troponin Testing

Use of High Sensitivity Cardiac Troponin in Ruling Out Emergency Patients with Acute Myocardial Injury and Infarction

Start: Oct 2020Est. completion: Oct 20241,000 patients
N/ACompleted
NCT04772157Siemens HealthineersCardiac Troponin Testing

Safe Emergency Department DIscharGE Rate (SEIGE)

Start: Oct 2020Est. completion: Oct 20241,000 patients
N/ACompleted
NCT03361995ZollCooling Procedure using the ZOLL Thermogard XP3 IVTM System

STEMI Cool Pilot Trial to Assess Cooling as an Adjunctive Therapy to PCI In Patients With Acute MI (Phase A)

Start: Feb 2020Est. completion: May 20220
N/AWithdrawn
NCT04451967Autonomous Therapeuticsthrombolysis

Acute Myocardial Infarction Study in Northeastern China

Start: Sep 2019Est. completion: Sep 20223,159 patients
N/AUnknown
NCT04050956SandozFrench Cohort of Myocardial Infarction Evaluation

French Cohort of Myocardial Infarction Evaluation

Start: Mar 2019Est. completion: Mar 204930,000 patients
N/ARecruiting
NCT03447834AbbottSelective intracoronary hypothermia + PPCI

EUROpean Intracoronary Cooling Evaluation in Patients With ST-elevation Myocardial Infarction.

Start: Jan 2019Est. completion: Jun 2023200 patients
N/AUnknown
NCT03893435Young BioPharmaSacubitril / Valsartan Oral Tablet [Entresto]

The Role of Sacubitril/Valsartan in Post-acute Myocardial Infarction

Start: Dec 2018Est. completion: Oct 2022192 patients
N/ACompleted
NCT03298659BiotronikiFR

iFR Guided Multi-vessel Revascularization During Percutaneous Coronary Intervention for Acute Myocardial Infarction

Start: Dec 2017Est. completion: May 20271,146 patients
N/AActive Not Recruiting
NCT03214029AbbottCardiac troponin testing

COmparisoN of High-sensitivity Cardiac TRoponin I and T ASsays Trial

Start: Nov 2017Est. completion: Dec 20252,000 patients
N/AActive Not Recruiting
NCT03173313ZollIntravascular permissive hypothermia as an adjunct to PCI

COOL AMI EU Pivotal Trial to Assess Cooling as an Adjunctive Therapy to PCI In Patients With Acute MI (Phase A)

Start: Apr 2017Est. completion: Aug 2019111 patients
N/ACompleted
NCT02531165AstraZenecaFentanyl

Platelet Inhibition After Pre-hospital Ticagrelor Using Fentanyl Compared to Morphine in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Start: Sep 2015Est. completion: Feb 201838 patients
N/ACompleted
NCT02509832ZollCooling + PCI

COOL AMI EU Pilot Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction

Start: Jul 2015Est. completion: Jun 2018100 patients
N/ACompleted
NCT02093377ResMedAdaptive servo-ventilation

ASV for Sleep Apnea After Myocardial Infarction

Start: Feb 2014Est. completion: Jun 202179 patients
N/ATerminated
NCT02070913ZollCOOL-AMI EU Case Series Clinical Study

COOL-AMI EU Case Series Clinical Study

Start: Sep 2013Est. completion: Apr 2019352 patients
N/ACompleted
NCT01498731Heidelberg PharmaDischarge home

Effect of the Biomarker Copeptin in Managing Patients With Suspected Acute Coronary Syndrome (ACS)

Start: Apr 2011Est. completion: Jun 2013902 patients
N/ACompleted
NCT01265706JW PharmaceuticalLivalo Acute Myocardial Infarction Study (LAMIS)

Livalo Acute Myocardial Infarction Study (LAMIS)

Start: Jul 2010Est. completion: Dec 20141,000 patients
N/ACompleted
NCT00704561MedtronicENDEAVOR® drug-eluting stent

Vessel Wall Response of the Zotarolimus Drug-eluting Stent Implanted in AMI Assessed by Optical Coherence Tomography

Start: Apr 2008Est. completion: Oct 200944 patients
N/ACompleted
NCT00805714JW PharmaceuticalLivalo Acute Myocardial Infarction Study

Livalo Acute Myocardial Infarction Study

Start: Apr 2007Est. completion: Mar 20111,128 patients
N/ACompleted
NCT03227159EppendorfStudy for Evaluation of Newly Onset Chest Pain and Rapid Diagnosis of Myocardial Necrosis

Study for Evaluation of Newly Onset Chest Pain and Rapid Diagnosis of Myocardial Necrosis

Start: Jan 2007Est. completion: Dec 20081,818 patients
N/ACompleted
NCT02806102AstraZenecaPercutaneous coronary intervention

CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction II (COREA-AMI II)

Start: Jan 2004Est. completion: Feb 201813,000 patients
N/AUnknown
NCT00145119MedtronicCARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial Infarction

CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial Infarction

Start: Aug 2001Est. completion: May 2007312 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

5 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 105,506 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.