Acute Myocardial Infarction

12
Pipeline Programs
18
Companies
26
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
4
1
2
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 26 programs with unclassified modality

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Rhythm Pharmaceuticals
3 programs
1
1
Implantable cardioverter defibrillatorPhase 4
Single Site PacingPhase 21 trial
CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial InfarctionN/A1 trial
Active Trials
NCT00145119Completed312Est. May 2007
NCT01213251Completed129Est. Apr 2016
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
3 programs
1
1
Implantable cardioverter defibrillatorPhase 41 trial
Metoprolol- Toprol XLPhase 11 trial
Percutaneous coronary interventionN/A1 trial
Active Trials
NCT02806102Unknown13,000Est. Feb 2018
NCT01523054Completed27Est. Apr 2002
NCT00157768Completed900Est. Oct 2007
C
CordisFL - Miami Lakes
1 program
1
Tenecteplase + UFHPhase 41 trial
Active Trials
NCT00257309Terminated266Est. Dec 2008
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
1
Empagliflozin 10 mgPhase 31 trial
Active Trials
NCT03087773Completed476Est. May 2022
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
enoxaparinPhase 31 trial
Active Trials
NCT00882635Completed44Est. Jun 2012
Abbott
AbbottABBOTT PARK, IL
4 programs
1
Triage Profiler S.O.B. PanelPhase 2/31 trial
Cardiac troponin testingN/A1 trial
Coronary and peripheral stentsN/A1 trial
Selective intracoronary hypothermia + PPCIN/A1 trial
Active Trials
NCT03214029Active Not Recruiting2,000Est. Dec 2025
NCT04573660Recruiting3,784Est. Nov 2031
NCT03447834Unknown200Est. Jun 2023
+1 more trials
CSL Behring
CSL BehringIL - Bradley
3 programs
1
2
CSL112Phase 21 trial
CSL_112Phase 21 trial
CSL112Phase 11 trial
Active Trials
NCT02427035Completed32Est. Feb 2016
NCT02108262Completed1,267Est. Mar 2016
NCT02742103Completed83Est. Jun 2017
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
TocilizumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT05350592Active Not Recruiting100Est. Sep 2025
Zoll
ZollCA - San Jose
4 programs
COOL-AMI EU Case Series Clinical StudyN/A1 trial
Cooling + PCIN/A1 trial
Cooling Procedure using the ZOLL Thermogard XP3 IVTM SystemN/A1 trial
Intravascular permissive hypothermia as an adjunct to PCIN/A1 trial
Active Trials
NCT02070913CompletedEst. Apr 2019
NCT02509832CompletedEst. Jun 2018
NCT03361995UnknownEst. Jul 2022
+1 more trials
Siemens Healthineers
Siemens HealthineersGermany - Forchheim
2 programs
Cardiac Troponin TestingN/A1 trial
Cardiac Troponin TestingN/A1 trial
Active Trials
NCT04772157CompletedEst. Oct 2024
NCT04280926CompletedEst. Oct 2024
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
1 program
Discharge homeN/A1 trial
Active Trials
NCT01498731Completed902Est. Jun 2013
Novartis
NovartisBASEL, Switzerland
1 program
French Cohort of Myocardial Infarction EvaluationN/A1 trial
Active Trials
NCT04050956Recruiting30,000Est. Mar 2049
AB
AP BiosciencesTaiwan - Taipei
1 program
Platelet Inhibition in the Acute Phase of STEMIN/A1 trial
Active Trials
NCT01144819CompletedEst. Aug 2010
Biotronik
BiotronikGermany - Berlin
1 program
iFRN/A1 trial
Active Trials
NCT03298659Active Not Recruiting1,146Est. May 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
CordisTenecteplase + UFH
AstraZenecaImplantable cardioverter defibrillator
AM-PharmaEmpagliflozin 10 mg
Boehringer Ingelheimenoxaparin
AbbottTriage Profiler S.O.B. Panel
Novo NordiskTocilizumab
CSL BehringCSL_112
CSL BehringCSL112
Rhythm PharmaceuticalsSingle Site Pacing
CSL BehringCSL112
AstraZenecaMetoprolol- Toprol XL
ZollCooling Procedure using the ZOLL Thermogard XP3 IVTM System
AbbottCoronary and peripheral stents
Siemens HealthineersCardiac Troponin Testing
Siemens HealthineersCardiac Troponin Testing

Showing 15 of 26 trials with date data

Clinical Trials (26)

Total enrollment: 54,974 patients across 26 trials

NCT00257309CordisTenecteplase + UFH

Thrombolysis Versus Primary Angioplasty for AMI in Elderly Patients

Start: Apr 2005Est. completion: Dec 2008266 patients
Phase 4Terminated
NCT00157768AstraZenecaImplantable cardioverter defibrillator

IRIS : Use of Implantable Defibrillator in High-risk Patients Early After Acute Myocardial Infarction

Start: Jun 1999Est. completion: Oct 2007900 patients
Phase 4Completed
NCT03087773AM-PharmaEmpagliflozin 10 mg

Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction

Start: May 2017Est. completion: May 2022476 patients
Phase 3Completed
NCT00882635Boehringer Ingelheimenoxaparin

The STREAM Percutaneous Coronary Intervention Anticoagulant Sub-study

Start: Oct 2008Est. completion: Jun 201244 patients
Phase 3Completed
NCT00206830AbbottTriage Profiler S.O.B. Panel

SHORTness of Breath In the Emergency Department (SHORTIE)

Start: Apr 2005Est. completion: Aug 2007306 patients
Phase 2/3Completed
NCT05350592Novo NordiskTocilizumab

Low-Dose Dobutamine and Single-Dose Tocilizumab in Acute Myocardial Infarction With High Risk of Cardiogenic Shock

Start: Mar 2022Est. completion: Sep 2025100 patients
Phase 2Active Not Recruiting
NCT02742103CSL BehringCSL_112

A Study of CSL112 in Adults With Moderate Renal Impairment and Acute Myocardial Infarction

Start: Aug 2016Est. completion: Jun 201783 patients
Phase 2Completed
NCT02108262CSL BehringCSL112

A Phase 2b Study of CSL112 in Subjects With Acute Myocardial Infarction.

Start: Aug 2014Est. completion: Mar 20161,267 patients
Phase 2Completed
NCT01213251Rhythm PharmaceuticalsSingle Site Pacing

Post-Myocardial Infarction Remodeling Prevention Therapy

Start: Dec 2010Est. completion: Apr 2016129 patients
Phase 2Completed
NCT02427035CSL BehringCSL112

A Study of CSL112 in Healthy Adults and in Adults With Moderate Renal Impairment

Start: May 2015Est. completion: Feb 201632 patients
Phase 1Completed
NCT01523054AstraZenecaMetoprolol- Toprol XL

Metoprolol in Acute Myocardial Infarction. A PK/PD Study

Start: Feb 2000Est. completion: Apr 200227 patients
Phase 1Completed
NCT03361995ZollCooling Procedure using the ZOLL Thermogard XP3 IVTM System

STEMI Cool Pilot Trial to Assess Cooling as an Adjunctive Therapy to PCI In Patients With Acute MI (Phase A)

Start: Nov 2020Est. completion: Jul 2022
N/AUnknown
NCT04573660AbbottCoronary and peripheral stents

Abbott Vascular Medical Device Registry

Start: Oct 2020Est. completion: Nov 20313,784 patients
N/ARecruiting
NCT04280926Siemens HealthineersCardiac Troponin Testing

Use of High Sensitivity Cardiac Troponin in Ruling Out Emergency Patients with Acute Myocardial Injury and Infarction

Start: Oct 2020Est. completion: Oct 2024
N/ACompleted
NCT04772157Siemens HealthineersCardiac Troponin Testing

Safe Emergency Department DIscharGE Rate (SEIGE)

Start: Oct 2020Est. completion: Oct 2024
N/ACompleted
NCT04050956NovartisFrench Cohort of Myocardial Infarction Evaluation

French Cohort of Myocardial Infarction Evaluation

Start: Mar 2019Est. completion: Mar 204930,000 patients
N/ARecruiting
NCT03447834AbbottSelective intracoronary hypothermia + PPCI

EUROpean Intracoronary Cooling Evaluation in Patients With ST-elevation Myocardial Infarction.

Start: Jan 2019Est. completion: Jun 2023200 patients
N/AUnknown
NCT03298659BiotronikiFR

iFR Guided Multi-vessel Revascularization During Percutaneous Coronary Intervention for Acute Myocardial Infarction

Start: Dec 2017Est. completion: May 20271,146 patients
N/AActive Not Recruiting
NCT03214029AbbottCardiac troponin testing

COmparisoN of High-sensitivity Cardiac TRoponin I and T ASsays Trial

Start: Nov 2017Est. completion: Dec 20252,000 patients
N/AActive Not Recruiting
NCT03173313ZollIntravascular permissive hypothermia as an adjunct to PCI

COOL AMI EU Pivotal Trial to Assess Cooling as an Adjunctive Therapy to PCI In Patients With Acute MI (Phase A)

Start: Apr 2017Est. completion: Aug 2019
N/ACompleted
NCT02509832ZollCooling + PCI

COOL AMI EU Pilot Trial to Assess Cooling as an Adjunctive Therapy to Percutaneous Intervention in Patients With Acute Myocardial Infarction

Start: Jul 2015Est. completion: Jun 2018
N/ACompleted
NCT02070913ZollCOOL-AMI EU Case Series Clinical Study

COOL-AMI EU Case Series Clinical Study

Start: Sep 2013Est. completion: Apr 2019
N/ACompleted
NCT01498731Heidelberg PharmaDischarge home

Effect of the Biomarker Copeptin in Managing Patients With Suspected Acute Coronary Syndrome (ACS)

Start: Apr 2011Est. completion: Jun 2013902 patients
N/ACompleted
NCT01144819AP BiosciencesPlatelet Inhibition in the Acute Phase of STEMI

Platelet Inhibition in the Acute Phase of STEMI

Start: Oct 2009Est. completion: Aug 2010
N/ACompleted
NCT02806102AstraZenecaPercutaneous coronary intervention

CardiOvascular Risk and idEntificAtion of Potential High-risk Population in Acute Myocardial Infarction II (COREA-AMI II)

Start: Jan 2004Est. completion: Feb 201813,000 patients
N/AUnknown
NCT00145119Rhythm PharmaceuticalsCARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial Infarction

CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial Infarction

Start: Aug 2001Est. completion: May 2007312 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 54,974 patients
18 companies competing in this space