Bridge Therapeutics

AL - BirminghamBiotechnology1 H-1B visas (FY2023)

Focus: Bridge Therapeutics is a public-stage biotechnology company headquartered in Birmingham, Alabama, specializing in pain treatments and marketed products across multiple therapeutic areas. The company generates 73% of revenue from ZUBSOLV (buprenorphine/naloxone), a treatment for opioid use disorder.

Cardiovascular Neurology Immunology Gastroenterology

Profile data last refreshed 16h ago · AI intelligence enriched 2w ago

Funding Stage

PUBLIC

Open Jobs

About Bridge Therapeutics

AI assessmentNot Hiring

No open roles listed right now. Follow Bridge Therapeutics to get notified when they start hiring — the background below is worth knowing for when they do.

Why Work Here

Data completeness

2/9 — Limited

Company HealthSolid

Pipeline

Early-stage

0 total

LOE Risk

1 in 5yr

OMEPRAZOLE

Hiring

0 open

Automated analysis based on publicly available data (FDA, SEC, ClinicalTrials.gov). May be incomplete or delayed. This score does not reflect insider knowledge and should not be used as the sole basis for investment or employment decisions.

Key Products

ZUBSOLV

Opioid use disorder

$28M Part D

Peak6.1yr

Flagship revenue driver accounting for 73% of company sales; naloxone partial agonist/antagonist mechanism addresses opioid dependence.

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

Established commercial revenue base with ZUBSOLV at peak lifecycle generating substantial Part D spending ($28M), providing financial stability for operations
Diversified product portfolio across pain, endocrinology, neurology, and gastroenterology reduces single-product dependency risk
Public company status offers equity upside and career progression visibility compared to private-stage peers

Watch Out For

Zero active clinical pipeline (0 Phase 1, Phase 2, Phase 3 programs) signals minimal R&D engine and limited internal innovation growth opportunities
Extreme revenue concentration (73% on ZUBSOLV) creates significant commercial vulnerability if product faces formulary or competitive pressures
No active job openings at time of data collection indicates potential hiring freeze or organizational contraction

Generated by Claude from Bridge Therapeutics's SEC filings, pipeline programs, hiring velocity, FDA actions, and WARN data. Inference, not editorial — verify before quoting.

RECORLEV

Cushing's syndrome

$10M Part D

Peak13.6yr

CYP450 11B1 inhibitor targeting cortisol overproduction; second-largest revenue contributor with extended patent protection.

CARBIDOPA

Parkinson's disease and parkinsonism

$466K Part D

Post-LOE

ANDA generic formulation of DOPA decarboxylase inhibitor; post-loss-of-exclusivity with minimal commercial revenue.

HEMADY

Thyroid eye disease (likely indication based on mechanism)

$159K Part D

Peak11.4yr

Corticosteroid with extended LOE; minimal Part D spending suggests niche/specialty indication.

VENLAFAXINE HYDROCHLORIDE

Major depressive disorder, social anxiety disorder

Post-LOE

ANDA generic SNRI antidepressant with no tracked Part D spending; post-exclusivity commodity product.

COLESTIPOL HYDROCHLORIDE

Hypercholesterolemia and hypertension

Post-LOE

ANDA generic bile-acid sequestrant with no tracked Part D spending; mature, low-revenue generic asset.

OMEPRAZOLE MAGNESIUM

GERD, heartburn

Post-LOE

ANDA generic proton-pump inhibitor with no tracked Part D spending; commoditized gastroenterology product.

ISOSORBIDE MONONITRATE

Angina pectoris due to coronary artery disease

Post-LOE

ANDA generic nitrate vasodilator with no tracked Part D spending; extended-release cardiovascular commodity.

Open Jobs (0)

No open positions listed yet. Check their careers page directly.

Interview Prep Quick Facts

Portfolio: 33 approved products

Top TAs: Neurology, Gastroenterology, Immunology

H-1B (2023): 1 approval

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Portfolio Health

Peak8 (24%)

LOE Approaching1 (3%)

Post-LOE24 (73%)

33 total products

Therapeutic Area Focus

9 marketed

5 marketed

5 marketed

5 marketed

5 marketed

Visa Sponsorship

Sponsors Work Visas

H-1B Petitions (FY2023)

Approved

Denied

100%

Rate

Source: USCIS H-1B Employer Data Hub

bisoprolol fumarate and hydrochlorothiazide

CLINICAL PHARMACOLOGY Bisoprolol fumarate and HCTZ have been used individually and in combination for the treatment of hypertension. The antihypertensive effects of these agents are additive; HCTZ 6.25 mg significantly increases the antihypertensive effect of bisoprolol fumarate. The incidence of hypokalemia with the bisoprolol fumarate and HCTZ 6.25 mg combination (B/H) is significantly lower than with HCTZ 25 mg. In clinical trials of bisoprolol fumarate and hydrochlorothiazide tablets, mean changes in serum potassium for patients treated with bisoprolol fumarate and hydrochlorothiazide tablets 2.5/6.25 mg, 5/6.25 mg or 10/6.25 mg or placebo were less than ± 0.1 mEq/L. Mean changes in serum potassium for patients treated with any dose of bisoprolol in combination with HCTZ 25 mg ranged from -0.1 to -0.3 mEq/L. Bisoprolol fumarate is a beta 1 -selective (cardioselective) adrenoceptor blocking agent without significant membrane stabilizing or intrinsic sympathomimetic activities in its therapeutic dose range. At higher doses (≥ 20 mg) bisoprolol fumarate also inhibits beta 2 -adrenoreceptors located in bronchial and vascular musculature. To retain relative selectivity, it is important to use the lowest effective dose. Hydrochlorothiazide is a benzothiadiazine diuretic. Thiazides affect renal tubular mechanisms of electrolyte reabsorption and increase excretion of sodium and chloride in approximately equivalent amounts. Natriuresis causes a secondary loss of potassium. Pharmacokinetics and Metabolism Bisoprolol fumarate and hydrochlorothiazide tablets In healthy volunteers, both bisoprolol fumarate and hydrochlorothiazide are well absorbed following oral administration of bisoprolol fumarate and hydrochlorothiazide tablets. No change is observed in the bioavailability of either agent when given together in a single tablet. Absorption is not affected whether bisoprolol fumarate and hydrochlorothiazide tablets is taken with or without food. Mean peak bisoprolol fumarate plasma concentrations of about 9.0 ng/mL, 19 ng/mL and 36 ng/mL occur approximately 3 hours after the administration of the 2.5 mg/6.25 mg, 5 mg/6.25 mg and 10 mg/6.25 mg combination tablets, respectively. Mean peak plasma hydrochlorothiazide concentrations of 30 ng/mL occur approximately 2.5 hours following the administration of the combination. Dose proportional increases in plasma bisoprolol concentrations are observed between the 2.5 and 5, as well as between the 5 and 10 mg doses. The elimination T1/2 of bisoprolol ranges from 7 to 15 hours, and that of hydrochlorothiazide ranges from 4 to 10 hours. The percent of dose excreted unchanged in urine is about 55% for bisoprolol and about 60% for hydrochlorothiazide. Bisoprolol Fumarate The absolute bioavailability after a 10 mg oral dose of bisoprolol fumarate is about 80%. The first pass metabolism of bisoprolol fumarate is about 20%. The pharmacokinetic profile of bisoprolol fumarate has been examined following single doses and at

Rare Diseases

2 marketed

Respiratory

2 marketed

Bridge Therapeutics

About Bridge Therapeutics

Why Work Here

Key Products

Watch Out For

Products & Portfolio (22)

Key Products by Revenue

Other Products (20)

Open Jobs (0)

Visa Sponsorship