NDAOPHTHALMICSUSPENSION/DROPS
Approved
Dec 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
5
Data completeness
4/8 — Partial
ZYLET (loteprednol etabonate and tobramycin) by Bausch + Lomb is healing. First approved in 2004.
Drug data last refreshed 11h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZYLET is a fixed-dose combination ophthalmic suspension containing loteprednol etabonate (corticosteroid) and tobramycin (aminoglycoside antibiotic) approved for bacterial ocular inflammation. It works by suppressing inflammatory mediators via phospholipase A2 inhibition while providing broad-spectrum antibacterial coverage against common ocular pathogens. The formulation targets post-operative and infectious ocular conditions requiring dual anti-inflammatory and antimicrobial action.
$0.004BPart D
LOE ApproachingStable
Product is in late-stage lifecycle with modest Part D utilization (~9,300 annual claims), signaling a mature franchise with smaller commercial support infrastructure.
Mechanism of Action
healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. There is no generally accepted explanation for the mechanism of action of ocular…
Pharmacologic Class:
Aminoglycoside Antibacterial
Indications
Worked on ZYLET at Bausch + Lomb? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.