ZOFRAN
LOE ApproachingNDAORALSOLUTION
Approved
Jan 1997
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
2/8 — Basic
Drug data last refreshed 20h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZOFRAN (ondansetron) is an oral solution small-molecule antiemetic indicated for prevention and treatment of nausea and vomiting, commonly associated with chemotherapy, radiation therapy, and post-operative recovery. The drug works as a selective 5-HT3 receptor antagonist in the chemoreceptor trigger zone and gastrointestinal tract. It represents a standard-of-care option in supportive oncology and perioperative medicine.
LOE Approaching
Mature product approaching loss-of-exclusivity with moderate competitive pressure (30); expect team consolidation and focus on retention and cost-management strategies.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (2)
Casopitant (Oral) And ZOFRAN To Prevent Postoperative Nausea And Vomiting In Women
Started Mar 2006
482 enrolled
Nausea and Vomiting, Postoperative
Casopitant And ZOFRAN To Prevent Post Operative Nausea And Vomiting In Women
Started Mar 2006
515 enrolled
Nausea and Vomiting, PostoperativePostoperative Nausea and Vomiting
Career Relevance
Working on ZOFRAN offers stability in a mature, essential-care product with high brand recognition but limited growth upside. Roles focus on defensive strategy, cost optimization, and market share retention as the product navigates LOE and generic competition.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.