NDAINJECTIONINJECTABLE
Approved
Oct 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ZINACEF (cefuroxime sodium) by R-Pharm US is mechanism of action cefuroxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Approved for including pneumonia, caused by streptococcus pneumoniae, haemophilus influenzae (including ampicillin-resistant strains) and 3 more indications. First approved in 1983.
Drug data last refreshed 3d ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZINACEF (cefuroxime sodium) is a second-generation cephalosporin antibiotic administered by injection that treats bacterial infections including pneumonia, meningitis, and urinary tract infections. It works by inhibiting bacterial cell wall synthesis and remains active against beta-lactamase-producing organisms. The drug is effective against a broad spectrum of Gram-positive and Gram-negative bacteria including Streptococcus pneumoniae, Haemophilus influenzae, and Klebsiella species.
LOE Approaching
As a legacy injectable antibiotic approaching loss of exclusivity with moderate competitive pressure, the ZINACEF franchise is likely contracting with reduced team investment focused on margin protection and managed care contracts.
Mechanism of Action
Mechanism of Action Cefuroxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefuroxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.
Indications (6)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.