NDATOPICALGEL
Approved
Nov 2006
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
ZIANA (clindamycin phosphate and tretinoin) by Bausch + Lomb. Approved for retinoid [epc]. First approved in 2006.
Drug data last refreshed 21h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZIANA is a fixed-dose topical gel combining clindamycin phosphate (antibiotic) and tretinoin (retinoid) approved for acne vulgaris. Clindamycin inhibits bacterial protein synthesis against Propionibacterium acnes, while tretinoin decreases follicular epithelial cohesiveness and stimulates cell turnover to extrude comedones. The combination addresses both bacterial infection and structural acne pathology in a single formulation.
$0.01BPart D
LOE ApproachingZIANA faces LOE pressure with minimal Part D spending ($10K in 2023, only 15 claims), indicating a niche or declining market position requiring transition planning.
Mechanism of Action
Pharmacologic Class:
Retinoid
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
ZIANA careers are contracting as LOE approaches with minimal Part D uptake; roles focus on defensive brand management, channel optimization, and transition support. Working on ZIANA offers experience in mature dermatology markets and generic defense strategy, but limited growth trajectory or career acceleration.
Brand ManagerField Sales Representative
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.