ZEPZELCA

Peak

lurbinectedin

NDAINTRAVENOUSPOWDERPriority Review
Approved
Jun 2020
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
17

Mechanism of Action

Alkylating Activity

Pharmacologic Class:

Alkylating Drug

Clinical Trials (5)

NCT07153055Phase 1/2Not Yet Recruiting

Lurbinectedin With Osimertinib in Transformed Small Cell Lung Cancer

Started May 2026
16 enrolled
Small Cell Lung Cancer ( SCLC )Transformed Small Cell Lung Cancer
NCT07459634Phase 2Not Yet Recruiting

A Study of Lurbinectedin in Combination With Durvalumab for the Treatment of Participants With ES-SCLC

Started Apr 2026
50 enrolled
Extensive-stage Small-cell Lung Cancer
NCT06217536Phase 1/2Withdrawn

Neoadjuvant Lurbinectedin and Preoperative Radiation for Treating Soft Tissue Sarcomas

Started Oct 2024
0
Locally Advanced Soft Tissue Sarcoma
NCT05572476Phase 2Withdrawn

Lurbinectedin Combined With Durvalumab in Pre-treated Patients With Extensive Stage Small-cell Lung Cancer

Started Oct 2023
0
Small Cell Lung CancerPlatinum-Sensitive Lung Small Cell CarcinomaExtensive-stage Small-cell Lung Cancer
NCT05918640Phase 1/2Recruiting

Lurbinectedin in FET-Fused Tumors

Started Jul 2023
63 enrolled
Ewing SarcomaDesmoplastic Small Round Cell TumorPediatric Cancer+1 more

Loss of Exclusivity

LOE Date
May 29, 2040
173 months away
Patent Expiry
May 29, 2040
Exclusivity Expiry
Oct 2, 2028

Patent Records (4)

Patent #ExpiryTypeUse Code
7763615
Dec 13, 2029
SubstanceProduct
U-2836
12324806
May 29, 2040
U-4212
12433890
May 29, 2040
U-4305
12440490
May 29, 2040
U-4252