NDAORALCAPSULE
Approved
Aug 2002
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
ZANAFLEX (tizanidine hydrochloride) by Enterprise Therapeutics is alpha-2-adrenergic receptor agonist and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. Approved for spasticity in adults. First approved in 2002.
Drug data last refreshed 13h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Zanaflex (tizanidine HCl) is an oral alpha-2-adrenergic receptor agonist approved in 2002 for spasticity in adults. It reduces spasticity by increasing presynaptic inhibition of motor neurons, with greatest effects on polysynaptic pathways. The drug works by reducing facilitation of spinal motor neurons.
LOE Approaching
Product approaching loss of exclusivity with limited linked job opportunities, suggesting smaller brand team size and defensive commercial strategy.
Mechanism of Action
alpha-2-adrenergic receptor agonist and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.
Indications (1)
Clinical Trials (1)
BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity
Started Dec 2003
135 enrolled
Upper Limb Spasticity
Career Relevance
Working on Zanaflex represents a defensive career opportunity in a declining product with minimal linked job openings and approaching loss of exclusivity. Role scope will likely focus on generic competition mitigation, managed care negotiations, and portfolio transition rather than growth initiatives.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.