NDAORALTABLET
Approved
Nov 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
5/8 — Partial
ZANAFLEX (tizanidine hydrochloride) by Enterprise Therapeutics is alpha-2-adrenergic receptor agonist and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. Approved for spasticity in adults. First approved in 1996.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZANAFLEX (tizanidine hydrochloride) is an oral small-molecule alpha-2-adrenergic receptor agonist approved in 1996 for treating spasticity in adults. It works by increasing presynaptic inhibition of motor neurons, primarily affecting polysynaptic spinal pathways to reduce muscle tone and spasticity.
$0.5MPart D
LOE ApproachingProduct is approaching loss of exclusivity with minimal Part D penetration, indicating a mature, consolidating commercial footprint with constrained team expansion opportunities.
Mechanism of Action
alpha-2-adrenergic receptor agonist and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons.
Indications (1)
Clinical Trials (1)
BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity
Started Dec 2003
135 enrolled
Upper Limb Spasticity
Career Relevance
ZANAFLEX currently shows zero linked job openings, reflecting its mature, declining commercial lifecycle. Career opportunities are constrained; roles would primarily support legacy brand management and transition planning rather than growth initiatives.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.