NDAINJECTIONINJECTABLE
Lifecycle
Pre-Launch
Data completeness
2/8 — Basic
XYLOCAINE W/ EPINEPHRINE (epinephrine; lidocaine hydrochloride) by AstraZeneca is impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Approved for regional anesthesia, analgesia for surgery, dental and 4 more indications.
Drug data last refreshed 1w ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Xylocaine with Epinephrine is a combination local anesthetic containing lidocaine hydrochloride and epinephrine, used for regional anesthesia and pain control in surgical, dental, and diagnostic procedures. The epinephrine acts as a vasoconstrictor to slow systemic absorption and prolong anesthetic effect by maintaining therapeutic tissue concentrations. Lidocaine blocks nerve impulses by increasing electrical excitation threshold and slowing action potential propagation.
Pre-Launch
Pre-launch stage offers opportunity to build brand infrastructure and market positioning in the competitive local anesthetic space; team growth depends on approval timeline and AstraZeneca's launch strategy.
Mechanism of Action
impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction…
Indications (7)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.