NDARECTALSUPPOSITORY
Approved
Mar 1964
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
XYLOCAINE (lidocaine) by AstraZeneca is clinical pharmacology mechanism of action: lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Approved for pain, local anesthesia, regional anesthesia and 1 more indications. First approved in 1964.
Drug data last refreshed 1w ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
XYLOCAINE (lidocaine) is a local anesthetic that stabilizes neuronal membranes by inhibiting ionic fluxes required for impulse initiation and conduction. Formulated as a rectal suppository, it provides topical anesthesia with onset of action in 3-5 minutes. It is used for local anesthetic indications where rectal administration is appropriate.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30), signaling a transition toward generic competition and potential team right-sizing.
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of action: Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Onset of anesthesia: Lidocaine Ointment 5% effects local, topical anesthesia. The…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.