NDAINJECTIONINJECTABLE
Approved
Nov 1948
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
XYLOCAINE DENTAL WITH EPINEPHRINE (epinephrine; lidocaine hydrochloride) by AstraZeneca is impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Approved for regional anesthesia, analgesia for surgery, dental and 4 more indications. First approved in 1948.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Xylocaine Dental with Epinephrine is a local anesthetic injection containing lidocaine hydrochloride and epinephrine, used for regional anesthesia and pain control during dental, oral surgery, and obstetrical procedures. The drug works by blocking nerve impulses through increased electrical excitation threshold and slowed action potential propagation. Epinephrine acts as a vasoconstrictor to prolong anesthetic effect by slowing systemic absorption.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30%), indicating portfolio transition and potential team restructuring ahead.
Mechanism of Action
impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction…
Indications (7)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.