NDAIMPLANTATIONIMPLANT
Approved
Aug 2020
Lifecycle
Peak
Competitive Pressure
0/100
Data completeness
3/8 — Basic
XARACOLL (bupivacaine hydrochloride) by Pfizer is impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. First approved in 2020.
Drug data last refreshed 1h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
XARACOLL is a bupivacaine hydrochloride implant approved by the FDA in August 2020 for local anesthesia via direct implantation. It works by blocking nerve impulses through elevation of the electrical excitation threshold and slowing action potential propagation. The formulation includes epinephrine as a vasoconstrictor to prolong anesthetic effect by delaying systemic absorption.
Peak6.3 years to LOE
Product is in peak commercial phase post-launch; teams are likely focused on market penetration, payer relationships, and surgical center adoption.
Mechanism of Action
impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
XARACOLL roles focus on surgical channel penetration, hospital formulary adoption, and health system relationships. This is a specialty surgical product requiring deep clinical engagement with anesthesiologists, surgeons, and perioperative teams.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.