VYLOY

GrowthmAb

zolbetuximab

BLAINJECTIONINJECTABLEPriority Review
Approved
Oct 2024
Lifecycle
Growth
Competitive Pressure
30/100
Clinical Trials
9

Mechanism of Action

Claudin 18.2-directed Antibody Interactions

Pharmacologic Class:

Claudin 18.2-directed Cytolytic Antibody

Clinical Trials (5)

NCT06396091Phase 1Active Not Recruiting

A Study of Zolbetuximab With Chemotherapy in Adults With Pancreatic Cancer

Started Sep 2025
12 enrolled
Metastatic Pancreatic Adenocarcinoma
NCT06901531Phase 3Recruiting

A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer

Started May 2025
500 enrolled
Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or CancerLocally Advanced Unresectable Gastric Adenocarcinoma or CancerMetastatic Gastric Adenocarcinoma or Cancer+1 more
NCT06902545N/ARecruiting

A Study to Observe the Safety of VYLOY (Zolbetuximab) in People in South Korea With Gastric or Gastroesophageal Junction Cancer.

Started Apr 2025
377 enrolled
Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or CancerLocally Advanced Unresectable Gastric Adenocarcinoma or CancerMetastatic Gastric Adenocarcinoma or Cancer+1 more
NCT04086758Phase 1Completed

A Pharmacokinetic Study of Zolbetuximab (IMAB362) in Chinese Subjects With Locally Advanced Unresectable or Metastatic Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma

Started Oct 2019
12 enrolled
Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma
NCT03816163Phase 2Active Not Recruiting

A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer

Started Mar 2019
393 enrolled
Pancreatic CancerMetastatic Pancreatic CancerMetastatic Pancreatic Adenocarcinoma