NDAORALTABLET
Approved
Sep 1967
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
VIVACTIL (protriptyline hydrochloride) by Teva is clinical pharmacology protriptyline hydrochloride is an antidepressant agent. Approved for symptoms of mental depression in patients. First approved in 1967.
Drug data last refreshed 12h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VIVACTIL (protriptyline hydrochloride) is a tricyclic antidepressant approved in 1967 for treating symptoms of mental depression. It works through an unknown mechanism distinct from monoamine oxidase inhibition, with a notably rapid onset of action (within one week) and minimal sedative properties. The drug is administered orally as a tablet and has slow excretion kinetics.
LOE Approaching
As a legacy antidepressant approaching loss of exclusivity with moderate competitive pressure (30/100), the brand team is likely consolidating resources toward maintenance rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Protriptyline hydrochloride is an antidepressant agent. The mechanism of its antidepressant action in man is not known. It is not a monoamine oxidase inhibitor, and it does not act primarily by stimulation of the central nervous system. Protriptyline has been found in some…
Indications (1)
Career Relevance
Working on VIVACTIL offers limited career acceleration; the product is in decline phase with minimal market expansion or innovation initiatives. Roles available are primarily maintenance-focused, supporting a shrinking customer base and managing generic transition.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.