NDAINJECTIONINJECTABLE
Approved
Sep 1957
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
5/8 — Partial
VISTARIL (hydroxyzine hydrochloride) by Pfizer is clinical pharmacology hydroxyzine hydrochloride is unrelated chemically to the phenothiazines, reserpine, meprobamate or the benzodiazepines. Approved for anxiety. First approved in 1957.
Drug data last refreshed 3d ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VISTARIL (hydroxyzine hydrochloride) is an injectable anxiolytic small molecule approved in 1957 that acts on subcortical CNS regions to suppress anxiety. It exhibits unique multimodal pharmacology including skeletal muscle relaxation, antihistaminic, analgesic, and antiemetic effects without being structurally related to benzodiazepines or phenothiazines. Clinical effects typically manifest within 15-30 minutes of administration.
$0.017BPart D
LOE ApproachingDeclining
Mature product in decline phase with minimal growth opportunity; brand team is likely focused on defensive positioning and cost management rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Hydroxyzine hydrochloride is unrelated chemically to the phenothiazines, reserpine, meprobamate or the benzodiazepines. Hydroxyzine is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the…
Indications (1)
Clinical Trials (1)
Does Preventive Analgesia Improve the Outcome of Demerol-Vistaril Procedural Sedations in Pediatric Dentistry
Started Oct 2013
88 enrolled
Pain
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.