NDAORALCAPSULE, EXTENDED RELEASE
Approved
May 1990
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
4
Data completeness
3/8 — Basic
VERELAN (verapamil hydrochloride) by R-Pharm US is mechanism of action essential hypertension verapamil hcl exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/minute is uncommon). First approved in 1990.
Drug data last refreshed 33m ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VERELAN is an extended-release oral capsule formulation of verapamil hydrochloride, a calcium channel blocker approved in 1990 for essential hypertension. It works by dilating peripheral arterioles and reducing total peripheral resistance, thereby lowering blood pressure without causing orthostatic hypotension or reflex tachycardia. The drug is indicated for patients requiring sustained antihypertensive control.
LOE Approaching
As a mature branded product approaching loss of exclusivity with moderate competitive pressure (30/100), the team is likely focused on managed care contracting and generic transition planning rather than growth initiatives.
Mechanism of Action
Mechanism of Action Essential Hypertension Verapamil HCl exerts antihypertensive effects by decreasing systemic vascular resistance, usually without orthostatic decreases in blood pressure or reflex tachycardia; bradycardia (rate less than 50 beats/minute is uncommon). Verapamil HCl regularly…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (4)
Fasting Study of Verapamil HCl Extended-Release Capsules 300 mg to Verelan® PM Extended-Release Capsules 300 mg
Started Mar 2006
72 enrolled
Healthy
Fasting Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg
Started Jan 2006
24 enrolled
Healthy
Food Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg
Started Jan 2006
24 enrolled
Healthy
Fasting Applesauce Study of Verapamil HCl Extended-Release Capsules 300 mg and Verelan® PM Extended-Release Capsules 300 mg
Started Jan 2006
24 enrolled
Healthy
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.