NDAINTRAVENOUSSOLUTION
Approved
Mar 1984
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
VERAPAMIL HYDROCHLORIDE (verapamil hydrochloride) by Teva is clinical pharmacology verapamil hydrochloride is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells. First approved in 1984.
Drug data last refreshed 6h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Verapamil hydrochloride is a calcium channel blocker administered intravenously that works by inhibiting calcium influx across cell membranes in vascular smooth muscle and cardiac tissue. It is indicated for angina (including vasospastic and unstable), cardiac arrhythmias (particularly atrial fibrillation and supraventricular tachycardia), and essential hypertension. The drug reduces myocardial oxygen demand and increases coronary blood flow through vasodilation and AV node conduction slowing.
LOE Approaching
Product approaching end-of-life with mature market dynamics; commercial teams likely focused on cost management and generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY Verapamil hydrochloride is a calcium ion influx inhibitor (slow-channel blocker or calcium ion antagonist) that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.