NDAINJECTIONINJECTABLE
Approved
Feb 2007
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
2/8 — Basic
Drug data last refreshed 20h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VAPRISOL (conivaptan hydrochloride) is an intravenous vaptans (vasopressin antagonist) approved for euvolemic and hypervolemic hyponatremia in hospitalized patients. It works by blocking vasopressin V1a and V2 receptors, promoting aquaresis and increasing serum sodium concentration. The drug is indicated for patients with heart failure, cirrhosis, or SIADH.
LOE Approaching
As an aging injectable therapy approaching LOE with moderate competitive pressure (30), brand team focus is likely on retained market position and maximizing remaining revenue before generic entry.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (3)
A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric Subjects With Euvolemic or Hypervolemic Hyponatremia
Started Feb 2012
4 enrolled
Hyponatremia
Diuretic and Renal Effects of Vaprisol When Administered Along With Furosemide and Nesiritide Continuous Infusion
Started Oct 2008
0Heart Failure
Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients
Started Aug 2008
6 enrolled
Hyponatremia
Career Relevance
Working on VAPRISOL offers experience in niche specialty pharmaceutical commercialization and hospital-based product management, though limited headcount and LOE trajectory present career risk. Roles emphasize efficiency and market defense rather than growth, making this suitable for experienced professionals managing product transitions or early-career candidates seeking disciplined, outcome-focused experience.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.