NDAINTRAVENOUSINJECTABLE
Approved
Dec 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3
Data completeness
2/8 — Basic
Drug Shortage Active
VAPRISOL is currently in shortage. Reason: Unavailable. This may impact manufacturing, supply chain, and quality hiring at the manufacturer.
Drug data last refreshed 1h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VAPRISOL (conivaptan hydrochloride) is an intravenous vaptans (vasopressin antagonist) approved in 2005 for treatment of euvolemic and hypervolemic hyponatremia in hospitalized patients. It works by blocking vasopressin V1a and V2 receptors, promoting aquaresis and sodium excretion. The drug addresses a niche acute-care indication with limited patient population.
LOE Approaching
Product is in advanced lifecycle stage with limited commercial momentum; teams are likely in maintenance mode with reduced headcount and marketing investment.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (3)
A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric Subjects With Euvolemic or Hypervolemic Hyponatremia
Started Feb 2012
4 enrolled
Hyponatremia
Diuretic and Renal Effects of Vaprisol When Administered Along With Furosemide and Nesiritide Continuous Infusion
Started Oct 2008
0Heart Failure
Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients
Started Aug 2008
6 enrolled
Hyponatremia
Career Relevance
VAPRISOL offers minimal direct career opportunities (0 linked jobs) due to its niche indication, narrow patient population, and current supply constraints. Roles are concentrated in hospital-based sales and medical affairs, with limited scope for growth or advancement as the product approaches LOE.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.