NDAORALTABLET
Approved
Aug 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
8
Data completeness
4/8 — Partial
VANTIN (cefpodoxime proxetil) by Pfizer is clinical pharmacology absorption and excretion: cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Approved for development of drug-resistant bacteria, maintain the effectiveness of cefpodoxime proxetil, other antibacterial drugs and 3 more indications. First approved in 1992.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VANTIN (cefpodoxime proxetil) is an oral third-generation cephalosporin prodrug that is absorbed from the GI tract and de-esterified to its active metabolite, cefpodoxime. It treats bacterial infections caused by susceptible organisms including respiratory, urinary, and skin infections, with documented efficacy in tonsillar and skin tissue penetration. The drug works by inhibiting bacterial cell wall synthesis via beta-lactam mechanism.
LOE Approaching
As a mature oral antibiotic approaching loss of exclusivity with low competitive spending ($30M competitive pressure index), brand teams face significant generic erosion and will likely focus on core franchise defense with smaller specialized teams.
Mechanism of Action
CLINICAL PHARMACOLOGY Absorption and Excretion: Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.