NDATRANSDERMALSYSTEM
Approved
Feb 2020
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
6
Data completeness
5/8 — Partial
TWIRLA (levonorgestrel/ethinyl estradiol) by Agile Therapeutics is estrogen receptor agonists [moa]. Approved for contraception. First approved in 2020.
Drug data last refreshed Yesterday · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TWIRLA is a transdermal contraceptive patch containing levonorgestrel and ethinyl estradiol, approved in 2020 as a non-daily hormonal birth control option. It works by suppressing ovulation through estrogen receptor agonism and progestin activity. The patch offers weekly dosing convenience compared to daily oral contraceptives.
LOE Approaching2.3 years to LOE
As a recently approved product entering the LOE window with 2.4 years of patent protection remaining, commercial teams face intensifying competitive pressure and should prepare for managed decline and generic transition strategy.
Mechanism of Action
Estrogen Receptor Agonists
Pharmacologic Class:
Estrogen
Indications (1)
Clinical Trials (6)
A Study to Evaluate the Drug Interaction Between Povorcitinib and the Oral Contraceptive Levonorgestrel/Ethinyl Estradiol in Healthy Adult Females
Started May 2024
24 enrolled
Healthy Participants
Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine
Started Jan 2024
60 enrolled
Healthy Participants
A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol
Started Jun 2018
14 enrolled
Healthy
Study to Evaluate Pharmacokinetics Profile, Wearability, and Safety of 2 Progestin-Only Patches
Started Jul 2012
36 enrolled
Healthy
Study Evaluating the Bioequivalence of Levonorgestrel/Ethinyl Estradiol Combinations in Cycling Women
Started Aug 2007
0Contraception
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.