NDATRANSDERMALSYSTEM
Approved
Feb 2020
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
7
Data completeness
4/8 — Partial
TWIRLA (levonorgestrel/ethinyl estradiol) by Agile Therapeutics is estrogen receptor agonists [moa]. First approved in 2020.
Drug data last refreshed 5h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TWIRLA is a transdermal contraceptive patch combining levonorgestrel and ethinyl estradiol, approved in 2020 as a once-weekly delivery system for birth control. It functions as an estrogen receptor agonist to prevent ovulation and alter cervical mucus, providing an alternative to oral contraceptives with improved adherence through the patch format.
LOE Approaching2.2 years to LOE
With LOE approaching in 2.2 years, TWIRLA's commercial team is transitioning from growth investments to defensive positioning and lifecycle extension strategies.
Mechanism of Action
Estrogen Receptor Agonists
Pharmacologic Class:
Estrogen
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (7)
A Study to Evaluate the Drug Interaction Between Povorcitinib and the Oral Contraceptive Levonorgestrel/Ethinyl Estradiol in Healthy Adult Females
Started May 2024
24 enrolled
Healthy Participants
Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine
Started Jan 2024
60 enrolled
Healthy Participants
A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol
Started Jun 2018
14 enrolled
Healthy
Study to Evaluate Pharmacokinetics Profile, Wearability, and Safety of 2 Progestin-Only Patches
Started Jul 2012
36 enrolled
Healthy
Evaluation of Pharmacodynamic Effects on Ovulation and Cycle Control
Started Sep 2007
123 enrolled
Ovulation Suppression
Worked on TWIRLA at Agile Therapeutics? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.