TUKYSA

PeakSM

tucatinib

NDAORALTABLETPriority Review
Approved
Apr 2020
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20

Mechanism of Action

Tyrosine Kinase Inhibitors

Pharmacologic Class:

Kinase Inhibitor

Clinical Trials (5)

NCT06873191N/ANot Yet Recruiting

A Study to Learn More About Tukysa Once it is Out in the Korean Market

Started Jan 2027
600 enrolled
HER2-positive Locally Advanced UnresectableMetastatic Breast Cancer
NCT07413939Phase 2/3Not Yet Recruiting

RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive

Started Apr 2026
650 enrolled
HER2-positive Breast Cancer
NCT06983691N/ANot Yet Recruiting

Patient Navigation for HER2+ Metastatic Breast Cancer Patients Treated With Tucatinib

Started Apr 2026
26 enrolled
HER2+ Metastatic Breast Cancer (MBC)
NCT07193394Phase 2Recruiting

Tucatinib and Trastuzumab in HER3-mutant and HER2-not Amplified Metastatic Breast Cancer

Started Jan 2026
20 enrolled
Metastatic Breast Cancer ( HER2 Negative)Unresectable Breast Cancer
NCT06961331N/ACompleted

Real World-clinical Outcomes of Tucatinib, Trastuzumab, and Capecitabine Following Trastuzumab Deruxtecan (T-DXd) for the Treatment of HER2-positive Metastatic Breast Cancer.

Started May 2025
86 enrolled
Metastatic HER2+ Advanced Breast Cancer

Loss of Exclusivity

LOE Date
Apr 27, 2038
147 months away
Patent Expiry
Apr 27, 2038
Exclusivity Expiry
Jan 19, 2030

Patent Records (5)

Patent #ExpiryTypeUse Code
9693989
May 9, 2027
Product
U-2788
8648087
Jan 14, 2031
SubstanceProduct
9457093
Oct 12, 2032
Product
U-2788
11504370
Mar 25, 2033
U-2788
12048698
Apr 27, 2038
U-3783