NDAOPHTHALMICSOLUTION/DROPSPriority Review
Approved
Dec 1994
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
3/8 — Basic
Priority Review
TRUSOPT (dorzolamide hydrochloride) by Merck & Co. is (ca) is an enzyme found in many tissues of the body including the eye. First approved in 1994.
Drug data last refreshed 44m ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TRUSOPT (dorzolamide hydrochloride) is a topical ophthalmic solution that reduces intraocular pressure (IOP) in glaucoma and ocular hypertension patients. It works by inhibiting carbonic anhydrase II in the ciliary processes, decreasing aqueous humor secretion and lowering IOP to prevent optic nerve damage and vision loss. This small-molecule approach has been a cornerstone of glaucoma therapy for three decades.
LOE Approaching
Product is in late-stage lifecycle with moderate competitive pressure (30), signaling potential team contraction and shift toward cost-management and lifecycle extension strategies rather than growth initiatives.
Mechanism of Action
(CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (1)
Safety and Efficacy of Triple Combination Therapy With Dorzolamide Hydrochloride / Brimonidine Tartrate / Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
Started Jul 2013
0GlaucomaOcular Hypertension
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.