NDAOPHTHALMICSOLUTION/DROPSPriority Review
Approved
Dec 1994
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
3/8 — Basic
Priority Review
TRUSOPT (dorzolamide hydrochloride) by Merck & Co. is (ca) is an enzyme found in many tissues of the body including the eye. First approved in 1994.
Drug data last refreshed 16h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TRUSOPT (dorzolamide hydrochloride) is a topical ophthalmic solution that reduces elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. It works by inhibiting carbonic anhydrase II in the ciliary processes, decreasing aqueous humor secretion and thereby lowering IOP. The drug addresses a major risk factor in optic nerve damage and glaucomatous vision loss.
LOE Approaching
Approaching loss of exclusivity signals transition from growth-stage teams to transition management and lifecycle extension strategies; expect consolidation of commercial roles.
Mechanism of Action
(CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (1)
Safety and Efficacy of Triple Combination Therapy With Dorzolamide Hydrochloride / Brimonidine Tartrate / Timolol Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension
Started Jul 2013
0GlaucomaOcular Hypertension
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.